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PUBMED FOR HANDHELDS

Journal Abstract Search

159 related items for PubMed ID: 18207395

  • 1. Proline bis-amides as potent dual orexin receptor antagonists.
    Bergman JM, Roecker AJ, Mercer SP, Bednar RA, Reiss DR, Ransom RW, Meacham Harrell C, Pettibone DJ, Lemaire W, Murphy KL, Li C, Prueksaritanont T, Winrow CJ, Renger JJ, Koblan KS, Hartman GD, Coleman PJ.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1425-30. PubMed ID: 18207395
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  • 2. N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists.
    Aissaoui H, Koberstein R, Zumbrunn C, Gatfield J, Brisbare-Roch C, Jenck F, Treiber A, Boss C.
    Bioorg Med Chem Lett; 2008 Nov 01; 18(21):5729-33. PubMed ID: 18845436
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  • 4. Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.
    Whitman DB, Cox CD, Breslin MJ, Brashear KM, Schreier JD, Bogusky MJ, Bednar RA, Lemaire W, Bruno JG, Hartman GD, Reiss DR, Harrell CM, Kraus RL, Li Y, Garson SL, Doran SM, Prueksaritanont T, Li C, Winrow CJ, Koblan KS, Renger JJ, Coleman PJ.
    ChemMedChem; 2009 Jul 01; 4(7):1069-74. PubMed ID: 19418500
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  • 5. Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.
    Winrow CJ, Tanis KQ, Reiss DR, Rigby AM, Uslaner JM, Uebele VN, Doran SM, Fox SV, Garson SL, Gotter AL, Levine DM, Roecker AJ, Coleman PJ, Koblan KS, Renger JJ.
    Neuropharmacology; 2010 Jan 01; 58(1):185-94. PubMed ID: 19596018
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  • 7. Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat.
    Holland PR, Akerman S, Goadsby PJ.
    Eur J Neurosci; 2006 Nov 01; 24(10):2825-33. PubMed ID: 17156207
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  • 8. Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor.
    Takai T, Takaya T, Nakano M, Akutsu H, Nakagawa A, Aimoto S, Nagai K, Ikegami T.
    J Pept Sci; 2006 Jul 01; 12(7):443-54. PubMed ID: 16429482
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  • 10. Gastroprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory afferent neuropeptides and nitric oxide.
    Brzozowski T, Konturek PC, Sliwowski Z, Drozdowicz D, Burnat G, Pajdo R, Pawlik M, Bielanski W, Kato I, Kuwahara A, Konturek SJ, Pawlik WW.
    Regul Pept; 2008 Jun 05; 148(1-3):6-20. PubMed ID: 18378017
    [Abstract] [Full Text] [Related]

  • 11. 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models.
    Walpole C, Ko SY, Brown M, Beattie D, Campbell E, Dickenson F, Ewan S, Hughes GA, Lemaire M, Lerpiniere J, Patel S, Urban L.
    J Med Chem; 1998 Aug 13; 41(17):3159-73. PubMed ID: 9703462
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  • 12. Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
    Di Fabio R, Pellacani A, Faedo S, Roth A, Piccoli L, Gerrard P, Porter RA, Johnson CN, Thewlis K, Donati D, Stasi L, Spada S, Stemp G, Nash D, Branch C, Kindon L, Massagrande M, Poffe A, Braggio S, Chiarparin E, Marchioro C, Ratti E, Corsi M.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5562-7. PubMed ID: 21831639
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  • 13. Orexin A attenuates unconditioned sexual motivation in male rats.
    Bai YJ, Li YH, Zheng XG, Han J, Yang XY, Sui N.
    Pharmacol Biochem Behav; 2009 Feb 15; 91(4):581-9. PubMed ID: 18952120
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  • 15. Distinct recognition of OX1 and OX2 receptors by orexin peptides.
    Ammoun S, Holmqvist T, Shariatmadari R, Oonk HB, Detheux M, Parmentier M, Akerman KE, Kukkonen JP.
    J Pharmacol Exp Ther; 2003 May 15; 305(2):507-14. PubMed ID: 12606634
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  • 17. Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists.
    McAtee LC, Sutton SW, Rudolph DA, Li X, Aluisio LE, Phuong VK, Dvorak CA, Lovenberg TW, Carruthers NI, Jones TK.
    Bioorg Med Chem Lett; 2004 Aug 16; 14(16):4225-9. PubMed ID: 15261275
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  • 18. Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists.
    Stasi LP, Artusi R, Bovino C, Buzzi B, Canciani L, Caselli G, Colace F, Garofalo P, Giambuzzi S, Larger P, Letari O, Mandelli S, Perugini L, Pucci S, Salvi M, Toro P.
    Bioorg Med Chem Lett; 2013 May 01; 23(9):2653-8. PubMed ID: 23535328
    [Abstract] [Full Text] [Related]

  • 19. Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.
    Coleman PJ, Schreier JD, McGaughey GB, Bogusky MJ, Cox CD, Hartman GD, Ball RG, Harrell CM, Reiss DR, Prueksaritanont T, Winrow CJ, Renger JJ.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2311-5. PubMed ID: 20207138
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