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Journal Abstract Search

292 related items for PubMed ID: 18217702

  • 1. Large neutral amino acid transporter enables brain drug delivery via prodrugs.
    Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J.
    J Med Chem; 2008 Feb 28; 51(4):932-6. PubMed ID: 18217702
    [Abstract] [Full Text] [Related]

  • 2. Brain uptake of ketoprofen-lysine prodrug in rats.
    Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J, Rautio J.
    Int J Pharm; 2010 Oct 31; 399(1-2):121-8. PubMed ID: 20727958
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  • 3. Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.
    Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J.
    J Med Chem; 2009 May 28; 52(10):3348-53. PubMed ID: 19402664
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  • 4. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.
    Peura L, Malmioja K, Laine K, Leppänen J, Gynther M, Isotalo A, Rautio J.
    Mol Pharm; 2011 Oct 03; 8(5):1857-66. PubMed ID: 21770378
    [Abstract] [Full Text] [Related]

  • 5. L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs.
    Puris E, Gynther M, Huttunen J, Petsalo A, Huttunen KM.
    J Control Release; 2017 Sep 10; 261():93-104. PubMed ID: 28662899
    [Abstract] [Full Text] [Related]

  • 6. Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.
    Puris E, Gynther M, de Lange ECM, Auriola S, Hammarlund-Udenaes M, Huttunen KM, Loryan I.
    Mol Pharm; 2019 Jul 01; 16(7):3261-3274. PubMed ID: 31180686
    [Abstract] [Full Text] [Related]

  • 7. System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells.
    Kim DK, Kim IJ, Hwang S, Kook JH, Lee MC, Shin BA, Bae CS, Yoon JH, Ahn SG, Kim SA, Kanai Y, Endou H, Kim JK.
    Neurosci Res; 2004 Dec 01; 50(4):437-46. PubMed ID: 15567481
    [Abstract] [Full Text] [Related]

  • 8. Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).
    Ylikangas H, Malmioja K, Peura L, Gynther M, Nwachukwu EO, Leppänen J, Laine K, Rautio J, Lahtela-Kakkonen M, Huttunen KM, Poso A.
    ChemMedChem; 2014 Dec 01; 9(12):2699-707. PubMed ID: 25205473
    [Abstract] [Full Text] [Related]

  • 9. L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier.
    Tomi M, Mori M, Tachikawa M, Katayama K, Terasaki T, Hosoya K.
    Invest Ophthalmol Vis Sci; 2005 Jul 01; 46(7):2522-30. PubMed ID: 15980244
    [Abstract] [Full Text] [Related]

  • 10. Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: interactions with the neutral and cationic amino acid transporter on the corneal epithelium.
    Anand BS, Katragadda S, Nashed YE, Mitra AK.
    Curr Eye Res; 2004 Jul 01; 29(2-3):153-66. PubMed ID: 15512962
    [Abstract] [Full Text] [Related]

  • 11. Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells.
    Patel M, Dalvi P, Gokulgandhi M, Kesh S, Kohli T, Pal D, Mitra AK.
    Int J Pharm; 2013 Feb 25; 443(1-2):245-53. PubMed ID: 23270998
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  • 15. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.
    Puris E, Gynther M, Huttunen J, Auriola S, Huttunen KM.
    Eur J Pharm Sci; 2019 Mar 01; 129():99-109. PubMed ID: 30625368
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  • 16. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.
    Peura L, Malmioja K, Huttunen K, Leppänen J, Hämäläinen M, Forsberg MM, Gynther M, Rautio J, Laine K.
    Pharm Res; 2013 Oct 01; 30(10):2523-37. PubMed ID: 24137801
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  • 19. Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells.
    Kobayashi K, Ohnishi A, Promsuk J, Shimizu S, Kanai Y, Shiokawa Y, Nagane M.
    Neurosurgery; 2008 Feb 01; 62(2):493-503; discussion 503-4. PubMed ID: 18382329
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