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Journal Abstract Search

247 related items for PubMed ID: 18218832

  • 1. Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease.
    Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, Cha B, Johnson KB, St George JA, Johnson MR, Boucher RC.
    J Pharmacol Exp Ther; 2008 Apr; 325(1):77-88. PubMed ID: 18218832
    [Abstract] [Full Text] [Related]

  • 2. Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease.
    Hirsh AJ, Sabater JR, Zamurs A, Smith RT, Paradiso AM, Hopkins S, Abraham WM, Boucher RC.
    J Pharmacol Exp Ther; 2004 Dec; 311(3):929-38. PubMed ID: 15273255
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis.
    Hirsh AJ, Molino BF, Zhang J, Astakhova N, Geiss WB, Sargent BJ, Swenson BD, Usyatinsky A, Wyle MJ, Boucher RC, Smith RT, Zamurs A, Johnson MR.
    J Med Chem; 2006 Jul 13; 49(14):4098-115. PubMed ID: 16821771
    [Abstract] [Full Text] [Related]

  • 4. Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease.
    Mall MA.
    Exp Physiol; 2009 Feb 13; 94(2):171-4. PubMed ID: 19060118
    [Abstract] [Full Text] [Related]

  • 5. Specific inhibition of epithelial Na+ channels by antisense oligonucleotides for the treatment of Na+ hyperabsorption in cystic fibrosis.
    Sobczak K, Segal A, Bangel-Ruland N, Semmler J, Van Driessche W, Lindemann H, Heermann R, Weber WM.
    J Gene Med; 2009 Sep 13; 11(9):813-23. PubMed ID: 19533590
    [Abstract] [Full Text] [Related]

  • 6.
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  • 7. Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways.
    Reihill JA, Walker B, Hamilton RA, Ferguson TE, Elborn JS, Stutts MJ, Harvey BJ, Saint-Criq V, Hendrick SM, Martin SL.
    Am J Respir Crit Care Med; 2016 Sep 15; 194(6):701-10. PubMed ID: 27014936
    [Abstract] [Full Text] [Related]

  • 8. N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells.
    Rochat T, Lacroix JS, Jornot L.
    J Cell Physiol; 2004 Oct 15; 201(1):106-16. PubMed ID: 15281093
    [Abstract] [Full Text] [Related]

  • 9. Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.
    Zhang LN, Karp P, Gerard CJ, Pastor E, Laux D, Munson K, Yan Z, Liu X, Godwin S, Thomas CP, Zabner J, Shi H, Caldwell CW, Peluso R, Carter B, Engelhardt JF.
    Mol Ther; 2004 Dec 15; 10(6):990-1002. PubMed ID: 15564131
    [Abstract] [Full Text] [Related]

  • 10.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 11. Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease.
    Coote K, Atherton-Watson HC, Sugar R, Young A, MacKenzie-Beevor A, Gosling M, Bhalay G, Bloomfield G, Dunstan A, Bridges RJ, Sabater JR, Abraham WM, Tully D, Pacoma R, Schumacher A, Harris J, Danahay H.
    J Pharmacol Exp Ther; 2009 May 15; 329(2):764-74. PubMed ID: 19190233
    [Abstract] [Full Text] [Related]

  • 12. NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia.
    Coote KJ, Paisley D, Czarnecki S, Tweed M, Watson H, Young A, Sugar R, Vyas M, Smith NJ, Baettig U, Groot-Kormelink PJ, Gosling M, Lock R, Ethell B, Williams G, Schumacher A, Harris J, Abraham WM, Sabater J, Poll CT, Faller T, Collingwood SP, Danahay H.
    Br J Pharmacol; 2015 Jun 15; 172(11):2814-26. PubMed ID: 25573195
    [Abstract] [Full Text] [Related]

  • 13. SPX-101 Is a Novel Epithelial Sodium Channel-targeted Therapeutic for Cystic Fibrosis That Restores Mucus Transport.
    Scott DW, Walker MP, Sesma J, Wu B, Stuhlmiller TJ, Sabater JR, Abraham WM, Crowder TM, Christensen DJ, Tarran R.
    Am J Respir Crit Care Med; 2017 Sep 15; 196(6):734-744. PubMed ID: 28481660
    [Abstract] [Full Text] [Related]

  • 14. Rationale for hypertonic saline therapy for cystic fibrosis lung disease.
    Tarran R, Donaldson S, Boucher RC.
    Semin Respir Crit Care Med; 2007 Jun 15; 28(3):295-302. PubMed ID: 17562499
    [Abstract] [Full Text] [Related]

  • 15. The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis lung disease.
    Moore PJ, Tarran R.
    Expert Opin Ther Targets; 2018 Aug 15; 22(8):687-701. PubMed ID: 30028216
    [Abstract] [Full Text] [Related]

  • 16. Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation.
    Schoenberger M, Althaus M.
    Expert Opin Ther Pat; 2013 Oct 15; 23(10):1383-9. PubMed ID: 23957246
    [Abstract] [Full Text] [Related]

  • 17. Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice.
    Zhou Z, Treis D, Schubert SC, Harm M, Schatterny J, Hirtz S, Duerr J, Boucher RC, Mall MA.
    Am J Respir Crit Care Med; 2008 Dec 15; 178(12):1245-56. PubMed ID: 18849497
    [Abstract] [Full Text] [Related]

  • 18. A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis.
    Knowles MR, Church NL, Waltner WE, Yankaskas JR, Gilligan P, King M, Edwards LJ, Helms RW, Boucher RC.
    N Engl J Med; 1990 Apr 26; 322(17):1189-94. PubMed ID: 2157983
    [Abstract] [Full Text] [Related]

  • 19. [Benzamil and mucoviscidosis. Primary culture of nasal mucosa as an electrophysiologic in vitro model].
    Blank U, Glanz H, Eistert B, Fryen A, Lindemann H, Hüls G, Clauss W, Weber WM.
    HNO; 1996 Apr 26; 44(4):172-7. PubMed ID: 8655347
    [Abstract] [Full Text] [Related]

  • 20. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice.
    Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC.
    Nat Med; 2004 May 26; 10(5):487-93. PubMed ID: 15077107
    [Abstract] [Full Text] [Related]

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