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Journal Abstract Search

275 related items for PubMed ID: 18222062

  • 1. Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.
    Petit E, Langouet S, Akhdar H, Nicolas-Nicolaz C, Guillouzo A, Morel F.
    Toxicol In Vitro; 2008 Apr; 22(3):632-42. PubMed ID: 18222062
    [Abstract] [Full Text] [Related]

  • 2. Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
    Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
    Dig Liver Dis; 2005 Apr; 37(4):282-97. PubMed ID: 15788214
    [Abstract] [Full Text] [Related]

  • 3. Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease.
    Kwan LY, Devlin SM, Mirocha JM, Papadakis KA.
    Dig Liver Dis; 2008 Jun; 40(6):425-32. PubMed ID: 18304898
    [Abstract] [Full Text] [Related]

  • 4. Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
    Dervieux T, Blanco JG, Krynetski EY, Vanin EF, Roussel MF, Relling MV.
    Cancer Res; 2001 Aug 01; 61(15):5810-6. PubMed ID: 11479220
    [Abstract] [Full Text] [Related]

  • 5. Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury.
    Tapner MJ, Jones BE, Wu WM, Farrell GC.
    J Hepatol; 2004 Mar 01; 40(3):454-63. PubMed ID: 15123360
    [Abstract] [Full Text] [Related]

  • 6. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes.
    LaDuke KE, Ehling S, Cullen JM, Bäumer W.
    Am J Vet Res; 2015 Jul 01; 76(7):649-55. PubMed ID: 26111096
    [Abstract] [Full Text] [Related]

  • 7. Selective inhibition of inflammatory gene expression in activated T lymphocytes: a mechanism of immune suppression by thiopurines.
    Thomas CW, Myhre GM, Tschumper R, Sreekumar R, Jelinek D, McKean DJ, Lipsky JJ, Sandborn WJ, Egan LJ.
    J Pharmacol Exp Ther; 2005 Feb 01; 312(2):537-45. PubMed ID: 15388785
    [Abstract] [Full Text] [Related]

  • 8. Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells.
    Fotoohi AK, Lindqvist M, Peterson C, Albertioni F.
    Nucleosides Nucleotides Nucleic Acids; 2006 Feb 01; 25(9-11):1039-44. PubMed ID: 17065061
    [Abstract] [Full Text] [Related]

  • 9. Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.
    Nelson JA, Carpenter JW, Rose LM, Adamson DJ.
    Cancer Res; 1975 Oct 01; 35(10):2872-8. PubMed ID: 1157053
    [Abstract] [Full Text] [Related]

  • 10. Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment.
    van Asseldonk DP, Seinen ML, de Boer NK, van Bodegraven AA, Mulder CJ.
    J Crohns Colitis; 2012 Feb 01; 6(1):95-101. PubMed ID: 22261533
    [Abstract] [Full Text] [Related]

  • 11. Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines.
    Fotoohi AK, Lindqvist M, Peterson C, Albertioni F.
    Biochem Biophys Res Commun; 2006 Apr 28; 343(1):208-15. PubMed ID: 16530731
    [Abstract] [Full Text] [Related]

  • 12. Differential role of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine and 6-thioguanine on human leukemia cells.
    Karim H, Ghalali A, Lafolie P, Vitols S, Fotoohi AK.
    Biochem Biophys Res Commun; 2013 Jul 26; 437(2):280-6. PubMed ID: 23811272
    [Abstract] [Full Text] [Related]

  • 13. Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells.
    Lambert CB, Spire C, Claude N, Guillouzo A.
    Toxicol Appl Pharmacol; 2009 Feb 01; 234(3):345-60. PubMed ID: 19084549
    [Abstract] [Full Text] [Related]

  • 14. Pharmacokinetics and pharmacodynamics of thiopurines in an in vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay.
    Pelin M, Genova E, Fusco L, Marisat M, Hofmann U, Favretto D, Lucafò M, Taddio A, Martelossi S, Ventura A, Stocco G, Schwab M, Decorti G.
    Chem Biol Interact; 2017 Sep 25; 275():189-195. PubMed ID: 28811125
    [Abstract] [Full Text] [Related]

  • 15. Review article: thiopurines in inflammatory bowel disease.
    Derijks LJ, Gilissen LP, Hooymans PM, Hommes DW.
    Aliment Pharmacol Ther; 2006 Sep 01; 24(5):715-29. PubMed ID: 16918876
    [Abstract] [Full Text] [Related]

  • 16. Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light.
    Zhang X, Jeffs G, Ren X, O'Donovan P, Montaner B, Perrett CM, Karran P, Xu YZ.
    DNA Repair (Amst); 2007 Mar 01; 6(3):344-54. PubMed ID: 17188583
    [Abstract] [Full Text] [Related]

  • 17. Drug Insight: pharmacology and toxicity of thiopurine therapy in patients with IBD.
    de Boer NK, van Bodegraven AA, Jharap B, de Graaf P, Mulder CJ.
    Nat Clin Pract Gastroenterol Hepatol; 2007 Dec 01; 4(12):686-94. PubMed ID: 18043678
    [Abstract] [Full Text] [Related]

  • 18. Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.
    Fotoohi AK, Wrabel A, Moshfegh A, Peterson C, Albertioni F.
    Biochem Pharmacol; 2006 Sep 28; 72(7):816-23. PubMed ID: 16859645
    [Abstract] [Full Text] [Related]

  • 19. Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment.
    Brouwer C, Vogels-Mentink TM, Keizer-Garritsen JJ, Trijbels FJ, Bökkerink JP, Hoogerbrugge PM, van Wering ER, Veerman AJ, De Abreu RA.
    Clin Chim Acta; 2005 Nov 28; 361(1-2):95-103. PubMed ID: 15990089
    [Abstract] [Full Text] [Related]

  • 20. Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro.
    Broekman MM, Roelofs HM, Wong DR, Kerstholt M, Leijten A, Hoentjen F, Peters WH, Wanten GJ, de Jong DJ.
    Cell Biol Toxicol; 2015 Jun 28; 31(3):161-71. PubMed ID: 25916701
    [Abstract] [Full Text] [Related]

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