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Journal Abstract Search

230 related items for PubMed ID: 18232650

  • 1. Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
    Cherney RJ, Mo R, Meyer DT, Nelson DJ, Lo YC, Yang G, Scherle PA, Mandlekar S, Wasserman ZR, Jezak H, Solomon KA, Tebben AJ, Carter PH, Decicco CP.
    J Med Chem; 2008 Feb 28; 51(4):721-4. PubMed ID: 18232650
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists.
    Cherney RJ, Nelson DJ, Lo YC, Yang G, Scherle PA, Jezak H, Solomon KA, Carter PH, Decicco CP.
    Bioorg Med Chem Lett; 2008 Sep 15; 18(18):5063-5. PubMed ID: 18722120
    [Abstract] [Full Text] [Related]

  • 3. Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
    Cherney RJ, Brogan JB, Mo R, Lo YC, Yang G, Miller PB, Scherle PA, Molino BF, Carter PH, Decicco CP.
    Bioorg Med Chem Lett; 2009 Feb 01; 19(3):597-601. PubMed ID: 19131247
    [Abstract] [Full Text] [Related]

  • 4. Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
    Cherney RJ, Mo R, Meyer DT, Voss ME, Lo YC, Yang G, Miller PB, Scherle PA, Tebben AJ, Carter PH, Decicco CP.
    Bioorg Med Chem Lett; 2009 Jul 01; 19(13):3418-22. PubMed ID: 19481449
    [Abstract] [Full Text] [Related]

  • 5. gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
    Cherney RJ, Mo R, Meyer DT, Voss ME, Yang MG, Santella JB, Duncia JV, Lo YC, Yang G, Miller PB, Scherle PA, Zhao Q, Mandlekar S, Cvijic ME, Barrish JC, Decicco CP, Carter PH.
    Bioorg Med Chem Lett; 2010 Apr 15; 20(8):2425-30. PubMed ID: 20346664
    [Abstract] [Full Text] [Related]

  • 6. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.
    Moree WJ, Kataoka K, Ramirez-Weinhouse MM, Shiota T, Imai M, Tsutsumi T, Sudo M, Endo N, Muroga Y, Hada T, Fanning D, Saunders J, Kato Y, Myers PL, Tarby CM.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1869-73. PubMed ID: 18313297
    [Abstract] [Full Text] [Related]

  • 7. Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2).
    Carter PH, Brown GD, Friedrich SR, Cherney RJ, Tebben AJ, Lo YC, Yang G, Jezak H, Solomon KA, Scherle PA, Decicco CP.
    Bioorg Med Chem Lett; 2007 Oct 01; 17(19):5455-61. PubMed ID: 17720492
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists.
    Xia M, Hou C, DeMong D, Pollack S, Pan M, Singer M, Matheis M, Murray W, Cavender D, Wachter M.
    Bioorg Med Chem Lett; 2008 Dec 15; 18(24):6468-70. PubMed ID: 18990568
    [Abstract] [Full Text] [Related]

  • 9. Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
    De Lucca GV, Kim UT, Vargo BJ, Duncia JV, Santella JB, Gardner DS, Zheng C, Liauw A, Wang Z, Emmett G, Wacker DA, Welch PK, Covington M, Stowell NC, Wadman EA, Das AM, Davies P, Yeleswaram S, Graden DM, Solomon KA, Newton RC, Trainor GL, Decicco CP, Ko SS.
    J Med Chem; 2005 Mar 24; 48(6):2194-211. PubMed ID: 15771462
    [Abstract] [Full Text] [Related]

  • 10. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.
    Hall SE, Mao A, Nicolaidou V, Finelli M, Wise EL, Nedjai B, Kanjanapangka J, Harirchian P, Chen D, Selchau V, Ribeiro S, Schyler S, Pease JE, Horuk R, Vaidehi N.
    Mol Pharmacol; 2009 Jun 24; 75(6):1325-36. PubMed ID: 19297521
    [Abstract] [Full Text] [Related]

  • 11. Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2.
    Shin N, Baribaud F, Wang K, Yang G, Wynn R, Covington MB, Feldman P, Gallagher KB, Leffet LM, Lo YY, Wang A, Xue CB, Newton RC, Scherle PA.
    Biochem Biophys Res Commun; 2009 Sep 18; 387(2):251-5. PubMed ID: 19576173
    [Abstract] [Full Text] [Related]

  • 12. Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
    Cherney RJ, Mo R, Meyer DT, Pechulis AD, Guaciaro MA, Lo YC, Yang G, Miller PB, Scherle PA, Zhao Q, Cvijic ME, Barrish JC, Decicco CP, Carter PH.
    Bioorg Med Chem Lett; 2012 Oct 01; 22(19):6181-4. PubMed ID: 22939233
    [Abstract] [Full Text] [Related]

  • 13. Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.
    Yang L, Butora G, Jiao RX, Pasternak A, Zhou C, Parsons WH, Mills SG, Vicario PP, Ayala JM, Cascieri MA, MacCoss M.
    J Med Chem; 2007 May 31; 50(11):2609-11. PubMed ID: 17461566
    [Abstract] [Full Text] [Related]

  • 14. Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.
    Yang L, Zhou C, Guo L, Morriello G, Butora G, Pasternak A, Parsons WH, Mills SG, MacCoss M, Vicario PP, Zweerink H, Ayala JM, Goyal S, Hanlon WA, Cascieri MA, Springer MS.
    Bioorg Med Chem Lett; 2006 Jul 15; 16(14):3735-9. PubMed ID: 16698264
    [Abstract] [Full Text] [Related]

  • 15. Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.
    Pasternak A, Marino D, Vicario PP, Ayala JM, Cascierri MA, Parsons W, Mills SG, Maccoss M, Yang L.
    J Med Chem; 2006 Aug 10; 49(16):4801-4. PubMed ID: 16884289
    [Abstract] [Full Text] [Related]

  • 16. Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives.
    Imai M, Shiota T, Kataoka K, Tarby CM, Moree WJ, Tsutsumi T, Sudo M, Ramirez-Weinhouse MM, Comer D, Sun CM, Yamagami S, Tanaka H, Morita T, Hada T, Greene J, Barnum D, Saunders J, Myers PL, Kato Y, Endo N.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5407-11. PubMed ID: 15454235
    [Abstract] [Full Text] [Related]

  • 17. Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2.
    Xue CB, Wang A, Meloni D, Zhang K, Kong L, Feng H, Glenn J, Huang T, Zhang Y, Cao G, Anand R, Zheng C, Xia M, Han Q, Robinson DJ, Storace L, Shao L, Li M, Brodmerkel CM, Covington M, Scherle P, Diamond S, Yeleswaram S, Vaddi K, Newton R, Hollis G, Friedman S, Metcalf B.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7473-8. PubMed ID: 21036044
    [Abstract] [Full Text] [Related]

  • 18. Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives.
    Moree WJ, Kataoka K, Ramirez-Weinhouse MM, Shiota T, Imai M, Sudo M, Tsutsumi T, Endo N, Muroga Y, Hada T, Tanaka H, Morita T, Greene J, Barnum D, Saunders J, Kato Y, Myers PL, Tarby CM.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5413-6. PubMed ID: 15454236
    [Abstract] [Full Text] [Related]

  • 19. Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2.
    Buntinx M, Hermans B, Goossens J, Moechars D, Gilissen RA, Doyon J, Boeckx S, Coesemans E, Van Lommen G, Van Wauwe JP.
    J Pharmacol Exp Ther; 2008 Oct 01; 327(1):1-9. PubMed ID: 18599682
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.
    Lim JW, Oh Y, Kim JH, Oak MH, Na Y, Lee JO, Lee SW, Cho H, Park WK, Choi G, Kang J.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2099-102. PubMed ID: 20223662
    [Abstract] [Full Text] [Related]

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