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242 related items for PubMed ID: 18251493

  • 1. Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.
    Evans GB, Furneaux RH, Greatrex B, Murkin AS, Schramm VL, Tyler PC.
    J Med Chem; 2008 Feb 28; 51(4):948-56. PubMed ID: 18251493
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase.
    Evans GB, Furneaux RH, Lewandowicz A, Schramm VL, Tyler PC.
    J Med Chem; 2003 Nov 20; 46(24):5271-6. PubMed ID: 14613329
    [Abstract] [Full Text] [Related]

  • 3. Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase.
    Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL.
    Biochemistry; 2003 May 27; 42(20):6057-66. PubMed ID: 12755607
    [Abstract] [Full Text] [Related]

  • 4. Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
    Singh V, Shi W, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL.
    Biochemistry; 2004 Jan 13; 43(1):9-18. PubMed ID: 14705926
    [Abstract] [Full Text] [Related]

  • 5. Acyclic ribooxacarbenium ion mimics as transition state analogues of human and malarial purine nucleoside phosphorylases.
    Taylor EA, Clinch K, Kelly PM, Li L, Evans GB, Tyler PC, Schramm VL.
    J Am Chem Soc; 2007 Jun 06; 129(22):6984-5. PubMed ID: 17497780
    [Abstract] [Full Text] [Related]

  • 6. Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.
    Evans GB, Furneaux RH, Schramm VL, Singh V, Tyler PC.
    J Med Chem; 2004 Jun 03; 47(12):3275-81. PubMed ID: 15163207
    [Abstract] [Full Text] [Related]

  • 7. One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.
    Miles RW, Tyler PC, Furneaux RH, Bagdassarian CK, Schramm VL.
    Biochemistry; 1998 Jun 16; 37(24):8615-21. PubMed ID: 9628722
    [Abstract] [Full Text] [Related]

  • 8. Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.
    Evans GB, Furneaux RH, Lewandowicz A, Schramm VL, Tyler PC.
    J Med Chem; 2003 Jul 17; 46(15):3412-23. PubMed ID: 12852771
    [Abstract] [Full Text] [Related]

  • 9. L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.
    Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL.
    J Am Chem Soc; 2008 Jan 23; 130(3):842-4. PubMed ID: 18154341
    [Abstract] [Full Text] [Related]

  • 10. Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.
    Clinch K, Evans GB, Fleet GW, Furneaux RH, Johnson SW, Lenz DH, Mee SP, Rands PR, Schramm VL, Taylor Ringia EA, Tyler PC.
    Org Biomol Chem; 2006 Mar 21; 4(6):1131-9. PubMed ID: 16525558
    [Abstract] [Full Text] [Related]

  • 11. 8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.
    Evans GB, Furneaux RH, Gainsford GJ, Hanson JC, Kicska GA, Sauve AA, Schramm VL, Tyler PC.
    J Med Chem; 2003 Jan 02; 46(1):155-60. PubMed ID: 12502369
    [Abstract] [Full Text] [Related]

  • 12. Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.
    Lewandowicz A, Ringia EA, Ting LM, Kim K, Tyler PC, Evans GB, Zubkova OV, Mee S, Painter GF, Lenz DH, Furneaux RH, Schramm VL.
    J Biol Chem; 2005 Aug 26; 280(34):30320-8. PubMed ID: 15961383
    [Abstract] [Full Text] [Related]

  • 13. Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction.
    Evans GB, Furneaux RH, Tyler PC, Schramm VL.
    Org Lett; 2003 Oct 02; 5(20):3639-40. PubMed ID: 14507192
    [Abstract] [Full Text] [Related]

  • 14. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.
    Evans GB, Furneaux RH, Lenz DH, Painter GF, Schramm VL, Singh V, Tyler PC.
    J Med Chem; 2005 Jul 14; 48(14):4679-89. PubMed ID: 16000004
    [Abstract] [Full Text] [Related]

  • 15. Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases.
    Lewandowicz A, Schramm VL.
    Biochemistry; 2004 Feb 17; 43(6):1458-68. PubMed ID: 14769022
    [Abstract] [Full Text] [Related]

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  • 19. Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.
    Kicska GA, Tyler PC, Evans GB, Furneaux RH, Shi W, Fedorov A, Lewandowicz A, Cahill SM, Almo SC, Schramm VL.
    Biochemistry; 2002 Dec 10; 41(49):14489-98. PubMed ID: 12463747
    [Abstract] [Full Text] [Related]

  • 20. Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases.
    Sauve AA, Cahill SM, Zech SG, Basso LA, Lewandowicz A, Santos DS, Grubmeyer C, Evans GB, Furneaux RH, Tyler PC, McDermott A, Girvin ME, Schramm VL.
    Biochemistry; 2003 May 20; 42(19):5694-705. PubMed ID: 12741826
    [Abstract] [Full Text] [Related]

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