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294 related items for PubMed ID: 18281497

  • 1. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.
    Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, Muthusamy N, Byrd JC, Cheng AL, Chen CS.
    Cancer Res; 2008 Feb 15; 68(4):1204-12. PubMed ID: 18281497
    [Abstract] [Full Text] [Related]

  • 2. Antitumor effects of dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, in human liver cancer cells are mediated through a reactive oxygen species-dependent mechanism.
    Lampiasi N, Azzolina A, D'Alessandro N, Umezawa K, McCubrey JA, Montalto G, Cervello M.
    Mol Pharmacol; 2009 Aug 15; 76(2):290-300. PubMed ID: 19461054
    [Abstract] [Full Text] [Related]

  • 3. N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells.
    Kim BM, Choi YJ, Han Y, Yun YS, Hong SH.
    Toxicol Appl Pharmacol; 2009 Aug 15; 239(1):87-97. PubMed ID: 19481559
    [Abstract] [Full Text] [Related]

  • 4. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.
    Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, Takahara S, Otsuki Y, Katsuoka Y.
    Anticancer Res; 2007 Aug 15; 27(1A):75-88. PubMed ID: 17352219
    [Abstract] [Full Text] [Related]

  • 5. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.
    Caja L, Sancho P, Bertran E, Iglesias-Serret D, Gil J, Fabregat I.
    Cancer Res; 2009 Oct 01; 69(19):7595-602. PubMed ID: 19773433
    [Abstract] [Full Text] [Related]

  • 6. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment.
    Azuma H, Takahara S, Horie S, Muto S, Otsuki Y, Katsuoka Y.
    J Urol; 2003 Jun 01; 169(6):2372-7. PubMed ID: 12771800
    [Abstract] [Full Text] [Related]

  • 7. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
    Yasui H, Hideshima T, Raje N, Roccaro AM, Shiraishi N, Kumar S, Hamasaki M, Ishitsuka K, Tai YT, Podar K, Catley L, Mitsiades CS, Richardson PG, Albert R, Brinkmann V, Chauhan D, Anderson KC.
    Cancer Res; 2005 Aug 15; 65(16):7478-84. PubMed ID: 16103102
    [Abstract] [Full Text] [Related]

  • 8. Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells.
    Hung WC, Chang HC, Chuang LY.
    Biochem J; 1999 Feb 15; 338 ( Pt 1)(Pt 1):161-6. PubMed ID: 9931312
    [Abstract] [Full Text] [Related]

  • 9. Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells.
    Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL.
    Cancer Res; 2008 Aug 15; 68(16):6698-707. PubMed ID: 18701494
    [Abstract] [Full Text] [Related]

  • 10. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.
    Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS.
    Hepatology; 2011 Jun 15; 53(6):1943-58. PubMed ID: 21391227
    [Abstract] [Full Text] [Related]

  • 11. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.
    Azuma H, Horie S, Muto S, Otsuki Y, Matsumoto K, Morimoto J, Gotoh R, Okuyama A, Suzuki S, Katsuoka Y, Takahara S.
    Anticancer Res; 2003 Jun 15; 23(4):3183-93. PubMed ID: 12926052
    [Abstract] [Full Text] [Related]

  • 12. MSFTZ, a flavanone derivative, induces human hepatoma cell apoptosis via a reactive oxygen species- and caspase-dependent mitochondrial pathway.
    Ying M, Tu C, Ying H, Hu Y, He Q, Yang B.
    J Pharmacol Exp Ther; 2008 Jun 15; 325(3):758-65. PubMed ID: 18323457
    [Abstract] [Full Text] [Related]

  • 13. Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms.
    Chen CY, Liu TZ, Chen CH, Wu CC, Cheng JT, Yiin SJ, Shih MK, Wu MJ, Chern CL.
    Food Chem Toxicol; 2007 Jul 15; 45(7):1268-76. PubMed ID: 17321026
    [Abstract] [Full Text] [Related]

  • 14. FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells.
    Shen Y, Cai M, Xia W, Liu J, Zhang Q, Xie H, Wang C, Wang X, Zheng S.
    Cancer Lett; 2007 Sep 08; 254(2):288-97. PubMed ID: 17462818
    [Abstract] [Full Text] [Related]

  • 15. Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines.
    Koike K, Takaki A, Tatsukawa M, Suzuki M, Shiraha H, Iwasaki Y, Sakaguchi K, Shiratori Y.
    Int J Oncol; 2006 Nov 08; 29(5):1253-61. PubMed ID: 17016659
    [Abstract] [Full Text] [Related]

  • 16. Cell death signal by glycine- and proline-rich plant glycoprotein is transferred from cytochrome c and nuclear factor kappa B to caspase 3 in Hep3B cells.
    Lee SJ, Lim KT.
    J Nutr Biochem; 2008 Mar 08; 19(3):166-74. PubMed ID: 17588735
    [Abstract] [Full Text] [Related]

  • 17. Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog.
    Ushitora Y, Tashiro H, Ogawa T, Tanimoto Y, Kuroda S, Kobayashi T, Miyata Y, Itamoto T, Asahara T, Ohdan H.
    Transplantation; 2009 Oct 27; 88(8):980-6. PubMed ID: 19855243
    [Abstract] [Full Text] [Related]

  • 18. Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells.
    Lu GD, Shen HM, Chung MC, Ong CN.
    Carcinogenesis; 2007 Sep 27; 28(9):1937-45. PubMed ID: 17698970
    [Abstract] [Full Text] [Related]

  • 19. Crude extracts of Euchresta formosana radix induce cytotoxicity and apoptosis in human hepatocellular carcinoma cell line (Hep3B).
    Hsu SC, Kuo CL, Lin JP, Lee JH, Lin CC, Su CC, Lin HJ, Chung JG.
    Anticancer Res; 2007 Sep 27; 27(4B):2415-25. PubMed ID: 17695533
    [Abstract] [Full Text] [Related]

  • 20. The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis.
    Okano J, Nagahara T, Matsumoto K, Murawaki Y.
    Oncol Rep; 2007 May 27; 17(5):1195-200. PubMed ID: 17390065
    [Abstract] [Full Text] [Related]


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