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420 related items for PubMed ID: 18281511

  • 1. Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
    Levesque AA, Fanous AA, Poh A, Eastman A.
    Mol Cancer Ther; 2008 Feb; 7(2):252-62. PubMed ID: 18281511
    [Abstract] [Full Text] [Related]

  • 2. Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints.
    Levesque AA, Kohn EA, Bresnick E, Eastman A.
    Oncogene; 2005 May 26; 24(23):3786-96. PubMed ID: 15782134
    [Abstract] [Full Text] [Related]

  • 3. Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
    Kohn EA, Ruth ND, Brown MK, Livingstone M, Eastman A.
    J Biol Chem; 2002 Jul 19; 277(29):26553-64. PubMed ID: 11953432
    [Abstract] [Full Text] [Related]

  • 4. A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
    Eastman A, Kohn EA, Brown MK, Rathman J, Livingstone M, Blank DH, Gribble GW.
    Mol Cancer Ther; 2002 Oct 19; 1(12):1067-78. PubMed ID: 12481430
    [Abstract] [Full Text] [Related]

  • 5. Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors.
    Chang LJ, Eastman A.
    Cell Cycle; 2012 May 01; 11(9):1818-26. PubMed ID: 22510560
    [Abstract] [Full Text] [Related]

  • 6. UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
    Sugiyama K, Shimizu M, Akiyama T, Tamaoki T, Yamaguchi K, Takahashi R, Eastman A, Akinaga S.
    Int J Cancer; 2000 Mar 01; 85(5):703-9. PubMed ID: 10699952
    [Abstract] [Full Text] [Related]

  • 7. Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.
    Tse AN, Schwartz GK.
    Cancer Res; 2004 Sep 15; 64(18):6635-44. PubMed ID: 15374978
    [Abstract] [Full Text] [Related]

  • 8. p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
    Furuta T, Hayward RL, Meng LH, Takemura H, Aune GJ, Bonner WM, Aladjem MI, Kohn KW, Pommier Y.
    Oncogene; 2006 May 11; 25(20):2839-49. PubMed ID: 16407843
    [Abstract] [Full Text] [Related]

  • 9. p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription.
    Lipski R, Lippincott DJ, Durden BC, Kaplan AR, Keiser HE, Park JH, Levesque AA.
    PLoS One; 2012 May 11; 7(8):e42615. PubMed ID: 22905155
    [Abstract] [Full Text] [Related]

  • 10. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
    Yu Q, La Rose J, Zhang H, Takemura H, Kohn KW, Pommier Y.
    Cancer Res; 2002 Oct 15; 62(20):5743-8. PubMed ID: 12384533
    [Abstract] [Full Text] [Related]

  • 11. UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines.
    Wu G, Lin N, Xu L, Liu B, Feitelson MA.
    BMC Cancer; 2013 Mar 28; 13():167. PubMed ID: 23537372
    [Abstract] [Full Text] [Related]

  • 12. p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
    Wang XQ, Stanbridge EJ, Lao X, Cai Q, Fan ST, Redpath JL.
    Radiat Res; 2007 Dec 28; 168(6):706-15. PubMed ID: 18088187
    [Abstract] [Full Text] [Related]

  • 13. Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.
    Tian H, Faje AT, Lee SL, Jorgensen TJ.
    Neoplasia; 2002 Dec 28; 4(2):171-80. PubMed ID: 11896572
    [Abstract] [Full Text] [Related]

  • 14. Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.
    Lossaint G, Besnard E, Fisher D, Piette J, Dulić V.
    Oncogene; 2011 Oct 13; 30(41):4261-74. PubMed ID: 21532626
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine.
    Sampath D, Shi Z, Plunkett W.
    Mol Pharmacol; 2002 Sep 13; 62(3):680-8. PubMed ID: 12181445
    [Abstract] [Full Text] [Related]

  • 16. Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.
    Demidova AR, Aau MY, Zhuang L, Yu Q.
    J Biol Chem; 2009 Feb 13; 284(7):4132-9. PubMed ID: 19060337
    [Abstract] [Full Text] [Related]

  • 17. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
    Shao RG, Cao CX, Shimizu T, O'Connor PM, Kohn KW, Pommier Y.
    Cancer Res; 1997 Sep 15; 57(18):4029-35. PubMed ID: 9307289
    [Abstract] [Full Text] [Related]

  • 18. Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells.
    Bork U, Lee WK, Kuchler A, Dittmar T, Thévenod F.
    Am J Physiol Renal Physiol; 2010 Feb 15; 298(2):F255-65. PubMed ID: 19923412
    [Abstract] [Full Text] [Related]

  • 19. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
    Wang Q, Fan S, Eastman A, Worland PJ, Sausville EA, O'Connor PM.
    J Natl Cancer Inst; 1996 Jul 17; 88(14):956-65. PubMed ID: 8667426
    [Abstract] [Full Text] [Related]

  • 20. Two 4N cell-cycle arrests contribute to cisplatin-resistance.
    Shen H, Perez RE, Davaadelger B, Maki CG.
    PLoS One; 2013 Jul 17; 8(4):e59848. PubMed ID: 23560058
    [Abstract] [Full Text] [Related]

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