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164 related items for PubMed ID: 18281518

  • 1. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
    Wang SW, Pan SL, Huang YC, Guh JH, Chiang PC, Huang DY, Kuo SC, Lee KH, Teng CM.
    Mol Cancer Ther; 2008 Feb; 7(2):350-60. PubMed ID: 18281518
    [Abstract] [Full Text] [Related]

  • 2. The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells.
    Chou LC, Yang JS, Huang LJ, Wu HC, Lu CC, Chiang JH, Chen KT, Kuo SC, Chung JG.
    J Gastroenterol; 2009 Feb; 44(10):1055-63. PubMed ID: 19688288
    [Abstract] [Full Text] [Related]

  • 3. CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells.
    Liu CW, Lin YC, Hung CM, Liu BL, Kuo SC, Ho CT, Way TD, Hung CH.
    Chem Biol Interact; 2018 Jun 01; 289():98-108. PubMed ID: 29679549
    [Abstract] [Full Text] [Related]

  • 4. CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation.
    Tsai AC, Pan SL, Sun HL, Wang CY, Peng CY, Wang SW, Chang YL, Kuo SC, Lee KH, Teng CM.
    J Biol Chem; 2010 Feb 19; 285(8):5497-506. PubMed ID: 20007968
    [Abstract] [Full Text] [Related]

  • 5. Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.
    Chen YC, Lu PH, Pan SL, Teng CM, Kuo SC, Lin TP, Ho YF, Huang YC, Guh JH.
    Biochem Pharmacol; 2007 Jun 30; 74(1):10-9. PubMed ID: 17475221
    [Abstract] [Full Text] [Related]

  • 6. The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.
    Huang SM, Yang JS, Tsai SC, Chen MH, Hsu MH, Lin HY, Chou LC, Chinag JH, Lee KH, Huang LJ, Kuo SC.
    Int J Oncol; 2011 May 30; 38(5):1357-64. PubMed ID: 21344160
    [Abstract] [Full Text] [Related]

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  • 8. BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
    Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY.
    Cancer Res; 2004 Jul 01; 64(13):4621-8. PubMed ID: 15231674
    [Abstract] [Full Text] [Related]

  • 9. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.
    Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC.
    Eur J Pharmacol; 2011 Nov 16; 670(1):96-104. PubMed ID: 21907193
    [Abstract] [Full Text] [Related]

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  • 11. Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.
    Lu PH, Kung FL, Kuo SC, Chueh SC, Guh JH.
    Naunyn Schmiedebergs Arch Pharmacol; 2006 Dec 16; 374(3):223-33. PubMed ID: 17102938
    [Abstract] [Full Text] [Related]

  • 12. CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway.
    Hung CM, Lin YC, Liu LC, Kuo SC, Ho CT, Way TD.
    Chem Biol Interact; 2016 Dec 25; 260():1-12. PubMed ID: 27769712
    [Abstract] [Full Text] [Related]

  • 13. 2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
    Feng B, Guo YW, Huang CG, Li L, Chen RH, Jiao BH.
    Chem Biol Interact; 2010 Jan 05; 183(1):142-53. PubMed ID: 19874809
    [Abstract] [Full Text] [Related]

  • 14. MIL-1, a novel antitumor agent derived from natural product millepachine, acts as tubulin polymerization inhibitor for the treatment of hepatocellular carcinoma.
    Yan J, Zhuang Q, Li Z, Xiong Y, He M, Kang C, Zhang Q, Han L, Liang E, Liu H, Ke P, Huang X.
    Eur J Pharmacol; 2021 May 05; 898():173975. PubMed ID: 33647258
    [Abstract] [Full Text] [Related]

  • 15. Induction of apoptosis by HAC-Y6, a novel microtubule inhibitor, through activation of the death receptor 4 signaling pathway in human hepatocellular carcinoma cells.
    Tsai JY, Hung CM, Bai ST, Huang CH, Chen WC, Chung JG, Kuo SC, Way TD, Huang LJ.
    Oncol Rep; 2010 Nov 05; 24(5):1169-78. PubMed ID: 20878107
    [Abstract] [Full Text] [Related]

  • 16. Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells.
    Chang YH, Yang JS, Kuo SC, Chung JG.
    Anticancer Res; 2009 Aug 05; 29(8):3139-48. PubMed ID: 19661327
    [Abstract] [Full Text] [Related]

  • 17. Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma.
    Xiang Q, Zhen Z, Deng DY, Wang J, Chen Y, Li J, Zhang Y, Wang F, Chen N, Chen H, Chen Y.
    J Exp Clin Cancer Res; 2015 Oct 12; 34():118. PubMed ID: 26458953
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of the insulin-like growth factor 1 receptor by CHM-1 blocks proliferation of glioblastoma multiforme cells.
    Lin YC, Hou SC, Hung CM, Lin JN, Chen WC, Ho CT, Kuo SC, Way TD.
    Chem Biol Interact; 2015 Apr 25; 231():119-26. PubMed ID: 25643584
    [Abstract] [Full Text] [Related]

  • 19. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma.
    Huynh H, Chow PK, Tai WM, Choo SP, Chung AY, Ong HS, Soo KC, Ong R, Linnartz R, Shi MM.
    J Hepatol; 2012 Mar 25; 56(3):595-601. PubMed ID: 22027573
    [Abstract] [Full Text] [Related]

  • 20. A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells.
    Ho CT, Chang YJ, Yang LX, Wei PL, Liu TZ, Liu JJ.
    PLoS One; 2015 Mar 25; 10(9):e0136340. PubMed ID: 26355599
    [Abstract] [Full Text] [Related]

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