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Journal Abstract Search

261 related items for PubMed ID: 18289852

  • 1. Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.
    Hanessian S, Simard D, Bayrakdarian M, Therrien E, Nilsson I, Fjellström O.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1972-6. PubMed ID: 18289852
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  • 2. From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs.
    Hanessian S, Therrien E, Zhang J, Otterlo Wv, Xue Y, Gustafsson D, Nilsson I, Fjellström O.
    Bioorg Med Chem Lett; 2009 Sep 15; 19(18):5429-32. PubMed ID: 19674897
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  • 5. Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics.
    Marinko P, Krbavcic A, Mlinsek G, Solmajer T, Bakija AT, Stegnar M, Stojan J, Kikelj D.
    Eur J Med Chem; 2004 Mar 15; 39(3):257-65. PubMed ID: 15051174
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  • 6. Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors.
    Parlow JJ, Kurumbail RG, Stegeman RA, Stevens AM, Stallings WC, South MS.
    J Med Chem; 2003 Oct 23; 46(22):4696-701. PubMed ID: 14561089
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  • 8. Preparation of L-proline based aeruginosin 298-A analogs: optimization of the P1-moiety.
    Wang G, Goyal N, Hopkinson B.
    Bioorg Med Chem Lett; 2009 Jul 15; 19(14):3798-803. PubMed ID: 19447619
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  • 9. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
    Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J.
    J Med Chem; 2007 May 17; 50(10):2399-407. PubMed ID: 17432843
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  • 10. Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles.
    Isaacs RC, Solinsky MG, Cutrona KJ, Newton CL, Naylor-Olsen AM, McMasters DR, Krueger JA, Lewis SD, Lucas BJ, Kuo LC, Yan Y, Lynch JJ, Lyle EA.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):2062-6. PubMed ID: 18291642
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  • 11. Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.
    Phillips G, Davey DD, Eagen KA, Koovakkat SK, Liang A, Ng HP, Pinkerton M, Trinh L, Whitlow M, Beatty AM, Morrissey MM.
    J Med Chem; 1999 May 20; 42(10):1749-56. PubMed ID: 10346927
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  • 14. Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
    Dullweber F, Stubbs MT, Musil D, Stürzebecher J, Klebe G.
    J Mol Biol; 2001 Oct 26; 313(3):593-614. PubMed ID: 11676542
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  • 17. Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors.
    Da Settimo F, Primofiore G, La Motta C, Salerno S, Novellino E, Greco G, Lavecchia A, Laneri S, Boldrini E.
    Bioorg Med Chem; 2005 Jan 17; 13(2):491-9. PubMed ID: 15598571
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  • 20. New pyridinone derivatives as potent HIV-1 nonnucleoside reverse transcriptase inhibitors.
    Le Van K, Cauvin C, de Walque S, Georges B, Boland S, Martinelli V, Demonté D, Durant F, Hevesi L, Van Lint C.
    J Med Chem; 2009 Jun 25; 52(12):3636-43. PubMed ID: 19469474
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