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Journal Abstract Search

227 related items for PubMed ID: 18291646

  • 1. Synthesis and SAR studies of indole-based MK2 inhibitors.
    Xiong Z, Gao DA, Cogan DA, Goldberg DR, Hao MH, Moss N, Pack E, Pargellis C, Skow D, Trieselmann T, Werneburg B, White A.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1994-9. PubMed ID: 18291646
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  • 2. Pyrazinoindolone inhibitors of MAPKAP-K2.
    Goldberg DR, Choi Y, Cogan D, Corson M, DeLeon R, Gao A, Gruenbaum L, Hao MH, Joseph D, Kashem MA, Miller C, Moss N, Netherton MR, Pargellis CP, Pelletier J, Sellati R, Skow D, Torcellini C, Tseng YC, Wang J, Wasti R, Werneburg B, Wu JP, Xiong Z.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):938-41. PubMed ID: 18221871
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  • 3. Indole RSK inhibitors. Part 1: discovery and initial SAR.
    Boyer SJ, Burke J, Guo X, Kirrane TM, Snow RJ, Zhang Y, Sarko C, Soleymanzadeh L, Swinamer A, Westbrook J, Dicapua F, Padyana A, Cogan D, Gao A, Xiong Z, Madwed JB, Kashem M, Kugler S, O'Neill MM.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):733-7. PubMed ID: 22100312
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  • 8. In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.
    Revesz L, Schlapbach A, Aichholz R, Dawson J, Feifel R, Hawtin S, Littlewood-Evans A, Koch G, Kroemer M, Möbitz H, Scheufler C, Velcicky J, Huppertz C.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4719-23. PubMed ID: 20591669
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  • 9. Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity.
    Kirrane TM, Boyer SJ, Burke J, Guo X, Snow RJ, Soleymanzadeh L, Swinamer A, Zhang Y, Madwed JB, Kashem M, Kugler S, O'Neill MM.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):738-42. PubMed ID: 22056746
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  • 10. 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
    Argiriadi MA, Ericsson AM, Harris CM, Banach DL, Borhani DW, Calderwood DJ, Demers MD, Dimauro J, Dixon RW, Hardman J, Kwak S, Li B, Mankovich JA, Marcotte D, Mullen KD, Ni B, Pietras M, Sadhukhan R, Sousa S, Tomlinson MJ, Wang L, Xiang T, Talanian RV.
    Bioorg Med Chem Lett; 2010 Jan 01; 20(1):330-3. PubMed ID: 19919896
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  • 11. Assessment of the putative binding conformation of a pyrazolopyridine class of inhibitors of MAPKAPK2 using computational studies.
    Miglani R, Cliffe IA, Voleti SR.
    Eur J Med Chem; 2010 Jan 01; 45(1):98-105. PubMed ID: 19850376
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  • 15. Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
    Gill AL, Frederickson M, Cleasby A, Woodhead SJ, Carr MG, Woodhead AJ, Walker MT, Congreve MS, Devine LA, Tisi D, O'Reilly M, Seavers LC, Davis DJ, Curry J, Anthony R, Padova A, Murray CW, Carr RA, Jhoti H.
    J Med Chem; 2005 Jan 27; 48(2):414-26. PubMed ID: 15658855
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  • 16. 5-ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer.
    Zhang N, Ayral-Kaloustian S, Anderson JT, Nguyen T, Das S, Venkatesan AM, Brooijmans N, Lucas J, Yu K, Hollander I, Mallon R.
    Bioorg Med Chem Lett; 2010 Jun 15; 20(12):3526-9. PubMed ID: 20483602
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  • 17. Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a.
    Onda K, Suzuki T, Shiraki R, Yonetoku Y, Negoro K, Momose K, Katayama N, Orita M, Yamaguchi T, Ohta M, Tsukamoto S.
    Bioorg Med Chem; 2008 May 15; 16(10):5452-64. PubMed ID: 18434170
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  • 20. Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy.
    Velcicky J, Feifel R, Hawtin S, Heng R, Huppertz C, Koch G, Kroemer M, Moebitz H, Revesz L, Scheufler C, Schlapbach A.
    Bioorg Med Chem Lett; 2010 Feb 01; 20(3):1293-7. PubMed ID: 20060294
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