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Journal Abstract Search

104 related items for PubMed ID: 18296048

  • 21. Discovery and SAR of spirochromane Akt inhibitors.
    Kallan NC, Spencer KL, Blake JF, Xu R, Heizer J, Bencsik JR, Mitchell IS, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2410-4. PubMed ID: 21392984
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  • 22. Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase.
    Staben ST, Heffron TP, Sutherlin DP, Bhat SR, Castanedo GM, Chuckowree IS, Dotson J, Folkes AJ, Friedman LS, Lee L, Lesnick J, Lewis C, Murray JM, Nonomiya J, Olivero AG, Plise E, Pang J, Prior WW, Salphati L, Rouge L, Sampath D, Tsui V, Wan NC, Wang S, Weismann C, Wu P, Zhu BY.
    Bioorg Med Chem Lett; 2010 Oct 15; 20(20):6048-51. PubMed ID: 20822905
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  • 24. Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells.
    Lee KW, Kim SG, Kim HP, Kwon E, You J, Choi HJ, Park JH, Kang BC, Im SA, Kim TY, Kim WH, Bang YJ.
    Cancer Res; 2008 Mar 15; 68(6):1916-26. PubMed ID: 18339873
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  • 26. The design and synthesis of novel alpha-ketoamide-based p38 MAP kinase inhibitors.
    Montalban AG, Boman E, Chang CD, Ceide SC, Dahl R, Dalesandro D, Delaet NG, Erb E, Ernst JT, Gibbs A, Kahl J, Kessler L, Lundström J, Miller S, Nakanishi H, Roberts E, Saiah E, Sullivan R, Wang Z, Larson CJ.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1772-7. PubMed ID: 18325768
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  • 31. The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.
    Hu C, Solomon VR, Ulibarri G, Lee H.
    Bioorg Med Chem; 2008 Sep 01; 16(17):7888-93. PubMed ID: 18691894
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  • 32. Design of selective, ATP-competitive inhibitors of Akt.
    Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J.
    J Med Chem; 2010 Jun 24; 53(12):4615-22. PubMed ID: 20481595
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  • 33. Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
    Addie M, Ballard P, Buttar D, Crafter C, Currie G, Davies BR, Debreczeni J, Dry H, Dudley P, Greenwood R, Johnson PD, Kettle JG, Lane C, Lamont G, Leach A, Luke RW, Morris J, Ogilvie D, Page K, Pass M, Pearson S, Ruston L.
    J Med Chem; 2013 Mar 14; 56(5):2059-73. PubMed ID: 23394218
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  • 34. Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines.
    Alberti MJ, Auten EP, Lackey KE, McDonald OB, Wood ER, Preugschat F, Cutler GJ, Kane-Carson L, Liu W, Jung DK.
    Bioorg Med Chem Lett; 2005 Aug 15; 15(16):3778-81. PubMed ID: 15993060
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  • 35. CDDO-Me inhibits proliferation, induces apoptosis, down-regulates Akt, mTOR, NF-kappaB and NF-kappaB-regulated antiapoptotic and proangiogenic proteins in TRAMP prostate cancer cells.
    Deeb D, Gao X, Dulchavsky SA, Gautam SC.
    J Exp Ther Oncol; 2008 Aug 15; 7(1):31-9. PubMed ID: 18472640
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