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Journal Abstract Search

304 related items for PubMed ID: 18341274

  • 1. Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
    Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM.
    J Med Chem; 2008 Apr 10; 51(7):2170-7. PubMed ID: 18341274
    [Abstract] [Full Text] [Related]

  • 2. Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
    Bousejra-El Garah F, Wong MH, Amewu RK, Muangnoicharoen S, Maggs JL, Stigliani JL, Park BK, Chadwick J, Ward SA, O'Neill PM.
    J Med Chem; 2011 Oct 13; 54(19):6443-55. PubMed ID: 21888440
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  • 5. Synthesis, antimalarial activity and cytotoxicity of substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes.
    Kumar N, Khan SI, Beena, Rajalakshmi G, Kumaradhas P, Rawat DS.
    Bioorg Med Chem; 2009 Aug 01; 17(15):5632-8. PubMed ID: 19574054
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  • 6. Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes.
    Atheaya H, Khan SI, Mamgain R, Rawat DS.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1446-9. PubMed ID: 18248990
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  • 7. Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials.
    Opsenica I, Opsenica D, Smith KS, Milhous WK, Solaja BA.
    J Med Chem; 2008 Apr 10; 51(7):2261-6. PubMed ID: 18330976
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  • 8. Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
    O'Neill PM, Amewu RK, Nixon GL, Bousejra ElGarah F, Mungthin M, Chadwick J, Shone AE, Vivas L, Lander H, Barton V, Muangnoicharoen S, Bray PG, Davies J, Park BK, Wittlin S, Brun R, Preschel M, Zhang K, Ward SA.
    Angew Chem Int Ed Engl; 2010 Aug 02; 49(33):5693-7. PubMed ID: 20629058
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  • 11. Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.
    Dong Y, Tang Y, Chollet J, Matile H, Wittlin S, Charman SA, Charman WN, Tomas JS, Scheurer C, Snyder C, Scorneaux B, Bajpai S, Alexander SA, Wang X, Padmanilayam M, Cheruku SR, Brun R, Vennerstrom JL.
    Bioorg Med Chem; 2006 Sep 15; 14(18):6368-82. PubMed ID: 16759871
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  • 12. Synthesis and antimalarial activity of dihydroperoxides and tetraoxanes conjugated with bis(benzyl)acetone derivatives.
    Franco LL, de Almeida MV, E Silva LF, Vieira PP, Pohlit AM, Valle MS.
    Chem Biol Drug Des; 2012 May 15; 79(5):790-7. PubMed ID: 22284812
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  • 13. Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.
    Amewu RK, Chadwick J, Hussain A, Panda S, Rinki R, Janneh O, Ward SA, Miguel C, Burrell-Saward H, Vivas L, O'Neill PM.
    Bioorg Med Chem; 2013 Dec 01; 21(23):7392-7. PubMed ID: 24148834
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  • 14. Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
    Vennerstrom JL, Dong Y, Andersen SL, Ager AL, Fu H, Miller RE, Wesche DL, Kyle DE, Gerena L, Walters SM, Wood JK, Edwards G, Holme AD, McLean WG, Milhous WK.
    J Med Chem; 2000 Jul 13; 43(14):2753-8. PubMed ID: 10893313
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  • 15. Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1).
    Terzić N, Opsenica D, Milić D, Tinant B, Smith KS, Milhous WK, Solaja BA.
    J Med Chem; 2007 Oct 18; 50(21):5118-27. PubMed ID: 17887664
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  • 16. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
    Wang X, Dong Y, Wittlin S, Charman SA, Chiu FC, Chollet J, Katneni K, Mannila J, Morizzi J, Ryan E, Scheurer C, Steuten J, Santo Tomas J, Snyder C, Vennerstrom JL.
    J Med Chem; 2013 Mar 28; 56(6):2547-55. PubMed ID: 23489135
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  • 17. Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
    Vennerstrom JL, Fu HN, Ellis WY, Ager AL, Wood JK, Andersen SL, Gerena L, Milhous WK.
    J Med Chem; 1992 Aug 07; 35(16):3023-7. PubMed ID: 1501229
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  • 18. The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
    Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R, Vennerstrom JL.
    J Med Chem; 2010 Jan 14; 53(1):481-91. PubMed ID: 19924861
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  • 19. Influence of stereoisomer of dispiro-1,2,4,5-tetraoxanes on their binding mode with heme and on antimalarial activity: molecular docking studies.
    Tonmunphean S, Wijitkosoom A, Tantirungrotechai Y.
    Bioorg Med Chem; 2004 May 01; 12(9):2005-12. PubMed ID: 15080904
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  • 20. Tetraoxane antimalarials and their reaction with Fe(II).
    Opsenica I, Terzić N, Opsenica D, Angelovski G, Lehnig M, Eilbracht P, Tinant B, Juranić Z, Smith KS, Yang YS, Diaz DS, Smith PL, Milhous WK, Doković D, Solaja BA.
    J Med Chem; 2006 Jun 29; 49(13):3790-9. PubMed ID: 16789736
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