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181 related items for PubMed ID: 18346771

  • 1. Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.
    Elferink MG, Olinga P, Draaisma AL, Merema MT, Bauerschmidt S, Polman J, Schoonen WG, Groothuis GM.
    Toxicol Appl Pharmacol; 2008 Jun 15; 229(3):300-9. PubMed ID: 18346771
    [Abstract] [Full Text] [Related]

  • 2. Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes.
    Elferink MG, Olinga P, van Leeuwen EM, Bauerschmidt S, Polman J, Schoonen WG, Heisterkamp SH, Groothuis GM.
    Toxicol Appl Pharmacol; 2011 May 15; 253(1):57-69. PubMed ID: 21420995
    [Abstract] [Full Text] [Related]

  • 3. Effects of acetaminophen on hepatic gene expression in mice.
    Jeong SY, Lim JS, Park HJ, Cho JW, Rana SV, Yoon S.
    Physiol Chem Phys Med NMR; 2006 May 15; 38(2):77-83. PubMed ID: 18472468
    [Abstract] [Full Text] [Related]

  • 4. Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices.
    Vatakuti S, Schoonen WG, Elferink ML, Groothuis GM, Olinga P.
    Toxicol In Vitro; 2015 Aug 15; 29(5):1012-20. PubMed ID: 25858767
    [Abstract] [Full Text] [Related]

  • 5. Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers.
    Hagens WI, Olinga P, Meijer DK, Groothuis GM, Beljaars L, Poelstra K.
    Liver Int; 2006 Mar 15; 26(2):232-9. PubMed ID: 16448462
    [Abstract] [Full Text] [Related]

  • 6. Relationship between hepatic gene expression profiles and hepatotoxicity in five typical hepatotoxicant-administered rats.
    Minami K, Saito T, Narahara M, Tomita H, Kato H, Sugiyama H, Katoh M, Nakajima M, Yokoi T.
    Toxicol Sci; 2005 Sep 15; 87(1):296-305. PubMed ID: 15976192
    [Abstract] [Full Text] [Related]

  • 7. In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes.
    Suzuki H, Inoue T, Matsushita T, Kobayashi K, Horii I, Hirabayashi Y, Inoue T.
    J Appl Toxicol; 2008 Mar 15; 28(2):227-36. PubMed ID: 18246545
    [Abstract] [Full Text] [Related]

  • 8. RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays.
    Bulera SJ, Eddy SM, Ferguson E, Jatkoe TA, Reindel JF, Bleavins MR, De La Iglesia FA.
    Hepatology; 2001 May 15; 33(5):1239-58. PubMed ID: 11343254
    [Abstract] [Full Text] [Related]

  • 9. Differential gene expression profiles in the steatosis/fibrosis model of rat liver by chronic administration of carbon tetrachloride.
    Chung H, Hong DP, Kim HJ, Jang KS, Shin DM, Ahn JI, Lee YS, Kong G.
    Toxicol Appl Pharmacol; 2005 Nov 01; 208(3):242-54. PubMed ID: 16239168
    [Abstract] [Full Text] [Related]

  • 10. Acute hepatotoxicity: a predictive model based on focused illumina microarrays.
    Zidek N, Hellmann J, Kramer PJ, Hewitt PG.
    Toxicol Sci; 2007 Sep 01; 99(1):289-302. PubMed ID: 17522070
    [Abstract] [Full Text] [Related]

  • 11. Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.
    Werle-Schneider G, Wölfelschneider A, von Brevern MC, Scheel J, Storck T, Müller D, Glöckner R, Bartsch H, Bartelmann M.
    Int J Toxicol; 2006 Sep 01; 25(5):379-95. PubMed ID: 16940010
    [Abstract] [Full Text] [Related]

  • 12. Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu.
    van de Bovenkamp M, Groothuis GM, Draaisma AL, Merema MT, Bezuijen JI, van Gils MJ, Meijer DK, Friedman SL, Olinga P.
    Toxicol Sci; 2005 May 01; 85(1):632-8. PubMed ID: 15728706
    [Abstract] [Full Text] [Related]

  • 13. Identification of potential genomic biomarkers of hepatotoxicity caused by reactive metabolites of N-methylformamide: Application of stable isotope labeled compounds in toxicogenomic studies.
    Mutlib A, Jiang P, Atherton J, Obert L, Kostrubsky S, Madore S, Nelson S.
    Chem Res Toxicol; 2006 Oct 01; 19(10):1270-83. PubMed ID: 17040096
    [Abstract] [Full Text] [Related]

  • 14. Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: a toxicogenomics approach.
    Kienhuis AS, Wortelboer HM, Hoflack JC, Moonen EJ, Kleinjans JC, van Ommen B, van Delft JH, Stierum RH.
    Drug Metab Dispos; 2006 Dec 01; 34(12):2083-90. PubMed ID: 16963487
    [Abstract] [Full Text] [Related]

  • 15. Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils.
    Waring JF, Liguori MJ, Luyendyk JP, Maddox JF, Ganey PE, Stachlewitz RF, North C, Blomme EA, Roth RA.
    J Pharmacol Exp Ther; 2006 Mar 01; 316(3):1080-7. PubMed ID: 16299187
    [Abstract] [Full Text] [Related]

  • 16. Gene expression-based in vivo and in vitro prediction of liver toxicity allows compound selection at an early stage of drug development.
    Roth A, Boess F, Landes C, Steiner G, Freichel C, Plancher JM, Raab S, de Vera Mudry C, Weiser T, Suter L.
    J Biochem Mol Toxicol; 2011 Mar 01; 25(3):183-94. PubMed ID: 21671310
    [Abstract] [Full Text] [Related]

  • 17. [Change in gene expression of inflammation-related genes induced in multiple organ dysfunction syndrome induced by infection of injuries in rat].
    Ban Y, Shen H, Li TS.
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2007 Mar 01; 19(3):146-9. PubMed ID: 17376266
    [Abstract] [Full Text] [Related]

  • 18. Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants.
    Huang Q, Jin X, Gaillard ET, Knight BL, Pack FD, Stoltz JH, Jayadev S, Blanchard KT.
    Mutat Res; 2004 May 18; 549(1-2):147-67. PubMed ID: 15120968
    [Abstract] [Full Text] [Related]

  • 19. Transcriptome responses to carbon tetrachloride and pyrene in the kidney and liver of juvenile rainbow trout (Oncorhynchus mykiss).
    Krasnov A, Koskinen H, Rexroad C, Afanasyev S, Mölsä H, Oikari A.
    Aquat Toxicol; 2005 Aug 15; 74(1):70-81. PubMed ID: 15963578
    [Abstract] [Full Text] [Related]

  • 20. Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents.
    Stoff-Khalili MA, Rivera AA, Le LP, Stoff A, Everts M, Contreras JL, Chen D, Teng L, Rots MG, Haisma HJ, Rocconi RP, Bauerschmitz GJ, Rein DT, Yamamoto M, Siegal GP, Dall P, Michael Mathis J, Curiel DT.
    Cancer Gene Ther; 2006 Jun 15; 13(6):606-18. PubMed ID: 16410819
    [Abstract] [Full Text] [Related]

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