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185 related items for PubMed ID: 18372345

  • 1. Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors.
    Dong M, Gao F, Pinon DI, Miller LJ.
    Mol Endocrinol; 2008 Jun; 22(6):1489-99. PubMed ID: 18372345
    [Abstract] [Full Text] [Related]

  • 2. Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocket.
    Dong M, Pinon DI, Miller LJ.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):638-41. PubMed ID: 22079758
    [Abstract] [Full Text] [Related]

  • 3. Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.
    Miller LJ, Chen Q, Lam PC, Pinon DI, Sexton PM, Abagyan R, Dong M.
    J Biol Chem; 2011 May 06; 286(18):15895-907. PubMed ID: 21454562
    [Abstract] [Full Text] [Related]

  • 4. Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: a region critical for biological activity.
    Chen Q, Pinon DI, Miller LJ, Dong M.
    J Biol Chem; 2010 Aug 06; 285(32):24508-18. PubMed ID: 20529866
    [Abstract] [Full Text] [Related]

  • 5. Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides.
    Dong M, Narang P, Pinon DI, Bordner AJ, Miller LJ.
    Peptides; 2010 Jun 06; 31(6):1094-8. PubMed ID: 20214947
    [Abstract] [Full Text] [Related]

  • 6. Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.
    Dong M, Lam PC, Pinon DI, Sexton PM, Abagyan R, Miller LJ.
    Mol Pharmacol; 2008 Aug 06; 74(2):413-22. PubMed ID: 18467541
    [Abstract] [Full Text] [Related]

  • 7. Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.
    Harikumar KG, Lam PC, Dong M, Sexton PM, Abagyan R, Miller LJ.
    J Biol Chem; 2007 Nov 09; 282(45):32834-43. PubMed ID: 17827151
    [Abstract] [Full Text] [Related]

  • 8. Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.
    Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ.
    Mol Pharmacol; 2007 Aug 09; 72(2):280-90. PubMed ID: 17475809
    [Abstract] [Full Text] [Related]

  • 9. Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors.
    Dong M, Pinon DI, Asmann YW, Miller LJ.
    Mol Pharmacol; 2006 Jul 09; 70(1):206-13. PubMed ID: 16531505
    [Abstract] [Full Text] [Related]

  • 10. Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints.
    Dong M, Pinon DI, Bordner AJ, Miller LJ.
    Bioorg Med Chem Lett; 2010 Oct 15; 20(20):6040-4. PubMed ID: 20813522
    [Abstract] [Full Text] [Related]

  • 11. Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probes.
    Chen Q, Pinon DI, Miller LJ, Dong M.
    J Biol Chem; 2009 Dec 04; 284(49):34135-44. PubMed ID: 19815559
    [Abstract] [Full Text] [Related]

  • 12. Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.
    Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ.
    J Biol Chem; 2011 Jul 08; 286(27):23888-99. PubMed ID: 21566140
    [Abstract] [Full Text] [Related]

  • 13. Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor.
    Miller LJ, Dong M, Harikumar KG, Gao F.
    Biochem Soc Trans; 2007 Aug 08; 35(Pt 4):709-12. PubMed ID: 17635130
    [Abstract] [Full Text] [Related]

  • 14. Mutational analysis of the glucagon receptor: similarities with the vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide (PACAP)/secretin receptors for recognition of the ligand's third residue.
    Perret J, Van Craenenbroeck M, Langer I, Vertongen P, Gregoire F, Robberecht P, Waelbroeck M.
    Biochem J; 2002 Mar 01; 362(Pt 2):389-94. PubMed ID: 11853547
    [Abstract] [Full Text] [Related]

  • 15. Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.
    Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE.
    J Biol Chem; 2016 Jul 15; 291(29):15119-30. PubMed ID: 27226600
    [Abstract] [Full Text] [Related]

  • 16. Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.
    Dong M, Te JA, Xu X, Wang J, Pinon DI, Storjohann L, Bordner AJ, Miller LJ.
    Biochemistry; 2011 Sep 27; 50(38):8181-92. PubMed ID: 21851058
    [Abstract] [Full Text] [Related]

  • 17. Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors.
    Yin Y, de Waal PW, He Y, Zhao LH, Yang D, Cai X, Jiang Y, Melcher K, Wang MW, Xu HE.
    J Biol Chem; 2017 Jun 16; 292(24):9865-9881. PubMed ID: 28356352
    [Abstract] [Full Text] [Related]

  • 18. Rational development of a high-affinity secretin receptor antagonist.
    Dong M, Harikumar KG, Raval SR, Milburn JE, Clark C, Alcala-Torano R, Mobarec JC, Reynolds CA, Ghirlanda G, Christopoulos A, Wootten D, Sexton PM, Miller LJ.
    Biochem Pharmacol; 2020 Jul 16; 177():113929. PubMed ID: 32217097
    [Abstract] [Full Text] [Related]

  • 19. Exploration of the endogenous agonist mechanism for activation of secretin and VPAC1 receptors using synthetic glycosylated peptides.
    Dong M, Pinon DI, Miller LJ.
    J Mol Neurosci; 2008 Nov 16; 36(1-3):254-9. PubMed ID: 18409024
    [Abstract] [Full Text] [Related]

  • 20. Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.
    Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.
    J Biol Chem; 2010 Mar 26; 285(13):9919-9931. PubMed ID: 20100828
    [Abstract] [Full Text] [Related]

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