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337 related items for PubMed ID: 18381794

  • 1. Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.
    Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton TJ, Brasington R, Joseph A, Reddy V, Eisen S, McLeod HL.
    J Rheumatol; 2008 Apr; 35(4):572-9. PubMed ID: 18381794
    [Abstract] [Full Text] [Related]

  • 2. Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis.
    Hughes LB, Beasley TM, Patel H, Tiwari HK, Morgan SL, Baggott JE, Saag KG, McNicholl J, Moreland LW, Alarcón GS, Bridges SL.
    Ann Rheum Dis; 2006 Sep; 65(9):1213-8. PubMed ID: 16439441
    [Abstract] [Full Text] [Related]

  • 3. Pharmacogenetic polymorphisms contributing to toxicity induced by methotrexate in the southern Spanish population with rheumatoid arthritis.
    Plaza-Plaza JC, Aguilera M, Cañadas-Garre M, Chemello C, González-Utrilla A, Faus Dader MJ, Calleja MA.
    OMICS; 2012 Nov; 16(11):589-95. PubMed ID: 23095111
    [Abstract] [Full Text] [Related]

  • 4. Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese patients with rheumatoid arthritis.
    Kato T, Hamada A, Mori S, Saito H.
    Drug Metab Pharmacokinet; 2012 Nov; 27(2):192-9. PubMed ID: 22104130
    [Abstract] [Full Text] [Related]

  • 5. Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis.
    Kumagai K, Hiyama K, Oyama T, Maeda H, Kohno N.
    Int J Mol Med; 2003 May; 11(5):593-600. PubMed ID: 12684695
    [Abstract] [Full Text] [Related]

  • 6. Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR , TYMS, and TCII genes and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis.
    Świerkot J, Ślęzak R, Karpiński P, Pawłowska J, Noga L, Szechiński J, Wiland P.
    Pol Arch Med Wewn; 2015 May; 125(3):152-61. PubMed ID: 25599563
    [Abstract] [Full Text] [Related]

  • 7. Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism.
    Bohanec Grabar P, Logar D, Lestan B, Dolzan V.
    Eur J Clin Pharmacol; 2008 Nov; 64(11):1057-68. PubMed ID: 18607581
    [Abstract] [Full Text] [Related]

  • 8. Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway.
    Chaabane S, Marzouk S, Akrout R, Ben Hamad M, Achour Y, Rebai A, Keskes L, Fourati H, Bahloul Z, Maalej A.
    Eur J Drug Metab Pharmacokinet; 2016 Aug; 41(4):385-93. PubMed ID: 26077125
    [Abstract] [Full Text] [Related]

  • 9. No correlation between MTHFR c.677 C > T, MTHFR c.1298 A > C, and ABCB1 c.3435 C > T polymorphisms and methotrexate therapeutic outcome of rheumatoid arthritis in West Algerian population.
    Boughrara W, Benzaoui A, Aberkane M, Moghtit FZ, Dorgham S, Lardjam-Hetraf AS, Ouhaibi-Djellouli H, Teixeira EP, Boudjema A.
    Inflamm Res; 2017 Jun; 66(6):505-513. PubMed ID: 28299396
    [Abstract] [Full Text] [Related]

  • 10. Relationship Between Polymorphisms in Methotrexate Pathway Genes and Outcome of Methotrexate Treatment in a Cohort of 119 Patients with Juvenile Idiopathic Arthritis.
    Zajc Avramovič M, Dolžan V, Toplak N, Accetto M, Lusa L, Avčin T.
    J Rheumatol; 2017 Aug; 44(8):1216-1223. PubMed ID: 28572465
    [Abstract] [Full Text] [Related]

  • 11. Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis.
    Shao W, Yuan Y, Li Y.
    Genet Test Mol Biomarkers; 2017 May; 21(5):275-285. PubMed ID: 28277784
    [Abstract] [Full Text] [Related]

  • 12. Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.
    Wessels JA, de Vries-Bouwstra JK, Heijmans BT, Slagboom PE, Goekoop-Ruiterman YP, Allaart CF, Kerstens PJ, van Zeben D, Breedveld FC, Dijkmans BA, Huizinga TW, Guchelaar HJ.
    Arthritis Rheum; 2006 Apr; 54(4):1087-95. PubMed ID: 16572443
    [Abstract] [Full Text] [Related]

  • 13. Impact of genetic variants of ATP binding cassette B1, AICAR transformylase/IMP cyclohydrolase, folyl-polyglutamatesynthetase, and methylenetetrahydrofolatereductase on methotrexate toxicity.
    Sala-Icardo L, Lamana A, Ortiz AM, García Lorenzo E, Moreno Fresneda P, García-Vicuña R, González-Álvaro I.
    Reumatol Clin; 2017 Apr; 13(6):318-325. PubMed ID: 27751863
    [Abstract] [Full Text] [Related]

  • 14. Are Thymidylate synthase and Methylene tetrahydrofolate reductase genes linked with methotrexate response (efficacy, toxicity) in Indian (Asian) rheumatoid arthritis patients?
    Ghodke Y, Chopra A, Joshi K, Patwardhan B.
    Clin Rheumatol; 2008 Jun; 27(6):787-9. PubMed ID: 18274813
    [Abstract] [Full Text] [Related]

  • 15. MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis.
    Sundbaum JK, Baecklund E, Eriksson N, Hallberg P, Kohnke H, Wadelius M.
    Pharmacogenomics; 2020 Apr; 21(5):337-346. PubMed ID: 32024416
    [Abstract] [Full Text] [Related]

  • 16. Expression of methotrexate transporters and metabolizing enzymes in rheumatoid synovial tissue.
    Stamp LK, Hazlett J, Highton J, Hessian PA.
    J Rheumatol; 2013 Sep; 40(9):1519-22. PubMed ID: 23858048
    [Abstract] [Full Text] [Related]

  • 17. Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis.
    Qiu Q, Huang J, Lin Y, Shu X, Fan H, Tu Z, Zhou Y, Xiao C.
    Medicine (Baltimore); 2017 Mar; 96(11):e6337. PubMed ID: 28296761
    [Abstract] [Full Text] [Related]

  • 18. Role of key TYMS polymorphisms on methotrexate therapeutic outcome in portuguese rheumatoid arthritis patients.
    Lima A, Seabra V, Bernardes M, Azevedo R, Sousa H, Medeiros R.
    PLoS One; 2014 Mar; 9(10):e108165. PubMed ID: 25279663
    [Abstract] [Full Text] [Related]

  • 19. Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.
    Chaabane S, Messedi M, Akrout R, Ben Hamad M, Turki M, Marzouk S, Keskes L, Bahloul Z, Rebai A, Ayedi F, Maalej A.
    Inflamm Res; 2018 Aug; 67(8):703-710. PubMed ID: 29796841
    [Abstract] [Full Text] [Related]

  • 20. The C677T polymorphism in the MTHFR gene is associated with the toxicity of methotrexate in a Spanish rheumatoid arthritis population.
    Cáliz R, del Amo J, Balsa A, Blanco F, Silva L, Sanmarti R, Martínez FG, Collado MD, Ramirez Mdel C, Tejedor D, Artieda M, Pascual-Salcedo D, Oreiro N, Andreu JL, Graell E, Simon L, Martínez A, Mulero J.
    Scand J Rheumatol; 2012 Feb; 41(1):10-4. PubMed ID: 22044028
    [Abstract] [Full Text] [Related]

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