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Journal Abstract Search

215 related items for PubMed ID: 18388877

  • 1. The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo.
    Tornio A, Niemi M, Neuvonen M, Laitila J, Kalliokoski A, Neuvonen PJ, Backman JT.
    Clin Pharmacol Ther; 2008 Sep; 84(3):403-11. PubMed ID: 18388877
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  • 4. Dose-dependent interaction between gemfibrozil and repaglinide in humans: strong inhibition of CYP2C8 with subtherapeutic gemfibrozil doses.
    Honkalammi J, Niemi M, Neuvonen PJ, Backman JT.
    Drug Metab Dispos; 2011 Oct; 39(10):1977-86. PubMed ID: 21778352
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  • 5. Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide.
    Niemi M, Leathart JB, Neuvonen M, Backman JT, Daly AK, Neuvonen PJ.
    Clin Pharmacol Ther; 2003 Oct; 74(4):380-7. PubMed ID: 14534525
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  • 6. The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects.
    Niemi M, Kajosaari LI, Neuvonen M, Backman JT, Neuvonen PJ.
    Br J Clin Pharmacol; 2004 Apr; 57(4):441-7. PubMed ID: 15025742
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  • 7. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone.
    Jaakkola T, Backman JT, Neuvonen M, Neuvonen PJ.
    Clin Pharmacol Ther; 2005 May; 77(5):404-14. PubMed ID: 15900286
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  • 8. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide.
    Niemi M, Backman JT, Neuvonen M, Neuvonen PJ.
    Diabetologia; 2003 Mar; 46(3):347-51. PubMed ID: 12687332
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  • 9. Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.
    Kudo T, Hisaka A, Sugiyama Y, Ito K.
    Drug Metab Dispos; 2013 Feb; 41(2):362-71. PubMed ID: 23139378
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  • 13. Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide.
    Varma MV, Lai Y, Kimoto E, Goosen TC, El-Kattan AF, Kumar V.
    Pharm Res; 2013 Apr; 30(4):1188-99. PubMed ID: 23307347
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  • 14. Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast.
    Karonen T, Filppula A, Laitila J, Niemi M, Neuvonen PJ, Backman JT.
    Clin Pharmacol Ther; 2010 Aug; 88(2):223-30. PubMed ID: 20592724
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  • 15. Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism.
    Kalliokoski A, Backman JT, Kurkinen KJ, Neuvonen PJ, Niemi M.
    Clin Pharmacol Ther; 2008 Oct; 84(4):488-96. PubMed ID: 19238654
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  • 19. Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites.
    Backman JT, Luurila H, Neuvonen M, Neuvonen PJ.
    Clin Pharmacol Ther; 2005 Aug; 78(2):154-67. PubMed ID: 16084850
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  • 20. Cyclosporine markedly raises the plasma concentrations of repaglinide.
    Kajosaari LI, Niemi M, Neuvonen M, Laitila J, Neuvonen PJ, Backman JT.
    Clin Pharmacol Ther; 2005 Oct; 78(4):388-99. PubMed ID: 16198658
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