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194 related items for PubMed ID: 18391035

  • 1. Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
    Yang G, Wang J, Cheng Y, Dutschman GE, Tanaka H, Baba M, Cheng YC.
    Antimicrob Agents Chemother; 2008 Jun; 52(6):2035-42. PubMed ID: 18391035
    [Abstract] [Full Text] [Related]

  • 2. Highly selective action of triphosphate metabolite of 4'-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT.
    Yang G, Dutschman GE, Wang CJ, Tanaka H, Baba M, Anderson KS, Cheng YC.
    Antiviral Res; 2007 Mar; 73(3):185-91. PubMed ID: 17109975
    [Abstract] [Full Text] [Related]

  • 3. Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
    Yang G, Paintsil E, Dutschman GE, Grill SP, Wang CJ, Wang J, Tanaka H, Hamasaki T, Baba M, Cheng YC.
    Antimicrob Agents Chemother; 2009 Nov; 53(11):4640-6. PubMed ID: 19704131
    [Abstract] [Full Text] [Related]

  • 4. Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes.
    Martinez SE, Bauman JD, Das K, Arnold E.
    Protein Sci; 2019 Mar; 28(3):587-597. PubMed ID: 30499174
    [Abstract] [Full Text] [Related]

  • 5. Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.
    Sohl CD, Kasiviswanathan R, Kim J, Pradere U, Schinazi RF, Copeland WC, Mitsuya H, Baba M, Anderson KS.
    Mol Pharmacol; 2012 Jul; 82(1):125-33. PubMed ID: 22513406
    [Abstract] [Full Text] [Related]

  • 6. Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate.
    Ray AS, Yang Z, Shi J, Hobbs A, Schinazi RF, Chu CK, Anderson KS.
    Biochemistry; 2002 Apr 23; 41(16):5150-62. PubMed ID: 11955063
    [Abstract] [Full Text] [Related]

  • 7. Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.
    Nitanda T, Wang X, Kumamoto H, Haraguchi K, Tanaka H, Cheng YC, Baba M.
    Antimicrob Agents Chemother; 2005 Aug 23; 49(8):3355-60. PubMed ID: 16048947
    [Abstract] [Full Text] [Related]

  • 8. Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP.
    Vaccaro JA, Parnell KM, Terezakis SA, Anderson KS.
    Antimicrob Agents Chemother; 2000 Jan 23; 44(1):217-21. PubMed ID: 10602755
    [Abstract] [Full Text] [Related]

  • 9. A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.
    Choi Y, George C, Comin MJ, Barchi JJ, Kim HS, Jacobson KA, Balzarini J, Mitsuya H, Boyer PL, Hughes SH, Marquez VE.
    J Med Chem; 2003 Jul 17; 46(15):3292-9. PubMed ID: 12852759
    [Abstract] [Full Text] [Related]

  • 10. Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.
    Crespan E, Locatelli GA, Cancio R, Hübscher U, Spadari S, Maga G.
    Antimicrob Agents Chemother; 2005 Jan 17; 49(1):342-9. PubMed ID: 15616314
    [Abstract] [Full Text] [Related]

  • 11. Synthesis, and in vitro enzymatic and antiviral evaluation of d4T polyphosphate derivatives as chain terminators.
    Yang S, Pannecouque C, Herdewijn P.
    Chem Biodivers; 2012 Oct 17; 9(10):2186-94. PubMed ID: 23081918
    [Abstract] [Full Text] [Related]

  • 12. Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.
    Paintsil E, Dutschman GE, Hu R, Grill SP, Lam W, Baba M, Tanaka H, Cheng YC.
    Antimicrob Agents Chemother; 2007 Nov 17; 51(11):3870-9. PubMed ID: 17724147
    [Abstract] [Full Text] [Related]

  • 13. Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases.
    Cherrington JM, Fuller MD, Mulato AS, Allen SJ, Kunder SC, Ussery MA, Lesnikowski Z, Schinazi RF, Sommadossi JP, Chen MS.
    Antimicrob Agents Chemother; 1996 May 17; 40(5):1270-3. PubMed ID: 8723481
    [Abstract] [Full Text] [Related]

  • 14. The Nucleoside Analog BMS-986001 Shows Greater In Vitro Activity against HIV-2 than against HIV-1.
    Smith RA, Raugi DN, Wu VH, Leong SS, Parker KM, Oakes MK, Sow PS, Ba S, Seydi M, Gottlieb GS, University of Washington-Dakar HIV-2 Study Group.
    Antimicrob Agents Chemother; 2015 Dec 17; 59(12):7437-46. PubMed ID: 26392486
    [Abstract] [Full Text] [Related]

  • 15. Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.
    Lennerstrand J, Stammers DK, Larder BA.
    Antimicrob Agents Chemother; 2001 Jul 17; 45(7):2144-6. PubMed ID: 11408240
    [Abstract] [Full Text] [Related]

  • 16. Prodrugs of γ-Alkyl-Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase.
    Zhao C, Weber S, Schols D, Balzarini J, Meier C.
    Angew Chem Int Ed Engl; 2020 Dec 01; 59(49):22063-22071. PubMed ID: 32379948
    [Abstract] [Full Text] [Related]

  • 17. Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance.
    Bertoletti N, Chan AH, Schinazi RF, Anderson KS.
    Molecules; 2020 Oct 21; 25(20):. PubMed ID: 33096918
    [Abstract] [Full Text] [Related]

  • 18. The M184V mutation in HIV-1 reverse transcriptase (RT) conferring lamivudine resistance does not result in broad cross-resistance to nucleoside analogue RT inhibitors.
    Miller V, Stürmer M, Staszewski S, Gröschel B, Hertogs K, de Béthune MP, Pauwels R, Harrigan PR, Bloor S, Kemp SD, Larder BA.
    AIDS; 1998 May 07; 12(7):705-12. PubMed ID: 9619801
    [Abstract] [Full Text] [Related]

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