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290 related items for PubMed ID: 18396898

  • 1. Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.
    Blum MM, Timperley CM, Williams GR, Thiermann H, Worek F.
    Biochemistry; 2008 May 06; 47(18):5216-24. PubMed ID: 18396898
    [Abstract] [Full Text] [Related]

  • 2. Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity.
    Amitai G, Adani R, Yacov G, Yishay S, Teitlboim S, Tveria L, Limanovich O, Kushnir M, Meshulam H.
    Toxicology; 2007 Apr 20; 233(1-3):187-98. PubMed ID: 17129656
    [Abstract] [Full Text] [Related]

  • 3. Reversed enantioselectivity of diisopropyl fluorophosphatase against organophosphorus nerve agents by rational design.
    Melzer M, Chen JC, Heidenreich A, Gäb J, Koller M, Kehe K, Blum MM.
    J Am Chem Soc; 2009 Dec 02; 131(47):17226-32. PubMed ID: 19894712
    [Abstract] [Full Text] [Related]

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  • 5. Structural characterization of the catalytic calcium-binding site in diisopropyl fluorophosphatase (DFPase)--comparison with related beta-propeller enzymes.
    Blum MM, Chen JC.
    Chem Biol Interact; 2010 Sep 06; 187(1-3):373-9. PubMed ID: 20206152
    [Abstract] [Full Text] [Related]

  • 6. Binding of a designed substrate analogue to diisopropyl fluorophosphatase: implications for the phosphotriesterase mechanism.
    Blum MM, Löhr F, Richardt A, Rüterjans H, Chen JC.
    J Am Chem Soc; 2006 Oct 04; 128(39):12750-7. PubMed ID: 17002369
    [Abstract] [Full Text] [Related]

  • 7. Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase.
    Amitai G, Gaidukov L, Adani R, Yishay S, Yacov G, Kushnir M, Teitlboim S, Lindenbaum M, Bel P, Khersonsky O, Tawfik DS, Meshulam H.
    FEBS J; 2006 May 04; 273(9):1906-19. PubMed ID: 16640555
    [Abstract] [Full Text] [Related]

  • 8. Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents.
    Briseño-Roa L, Hill J, Notman S, Sellers D, Smith AP, Timperley CM, Wetherell J, Williams NH, Williams GR, Fersht AR, Griffiths AD.
    J Med Chem; 2006 Jan 12; 49(1):246-55. PubMed ID: 16392809
    [Abstract] [Full Text] [Related]

  • 9. Monitoring the hydrolysis of toxic organophosphonate nerve agents in aqueous buffer and in bicontinuous microemulsions by use of diisopropyl fluorophosphatase (DFPase) with (1)H- (31)P HSQC NMR spectroscopy.
    Gäb J, Melzer M, Kehe K, Wellert S, Hellweg T, Blum MM.
    Anal Bioanal Chem; 2010 Feb 12; 396(3):1213-21. PubMed ID: 19943158
    [Abstract] [Full Text] [Related]

  • 10. Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid diisopropylfluorophosphatase.
    Belinskaya T, Pattabiraman N, diTargiani R, Choi M, Saxena A.
    Biochim Biophys Acta; 2012 May 12; 1824(5):701-10. PubMed ID: 22401958
    [Abstract] [Full Text] [Related]

  • 11. Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.
    Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F.
    Toxicol Lett; 2011 Sep 25; 206(1):14-23. PubMed ID: 21683774
    [Abstract] [Full Text] [Related]

  • 12. Theoretical Studies on Catalysis Mechanisms of Serum Paraoxonase 1 and Phosphotriesterase Diisopropyl Fluorophosphatase Suggest the Alteration of Substrate Preference from Paraoxonase to DFP.
    Zhang H, Yang L, Ma YY, Zhu C, Lin S, Liao RZ.
    Molecules; 2018 Jul 07; 23(7):. PubMed ID: 29986514
    [Abstract] [Full Text] [Related]

  • 13. In vitro and in vivo efficacy of PEGylated diisopropyl fluorophosphatase (DFPase).
    Melzer M, Heidenreich A, Dorandeu F, Gäb J, Kehe K, Thiermann H, Letzel T, Blum MM.
    Drug Test Anal; 2012 Jul 07; 4(3-4):262-70. PubMed ID: 22174192
    [Abstract] [Full Text] [Related]

  • 14. Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.
    Ashani Y, Gupta RD, Goldsmith M, Silman I, Sussman JL, Tawfik DS, Leader H.
    Chem Biol Interact; 2010 Sep 06; 187(1-3):362-9. PubMed ID: 20303930
    [Abstract] [Full Text] [Related]

  • 15. Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q).
    Stenzel J, Worek F, Eyer P.
    Biochem Pharmacol; 2007 Nov 01; 74(9):1390-400. PubMed ID: 17714697
    [Abstract] [Full Text] [Related]

  • 16. In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity.
    diTargiani RC, Chandrasekaran L, Belinskaya T, Saxena A.
    Chem Biol Interact; 2010 Sep 06; 187(1-3):349-54. PubMed ID: 20176006
    [Abstract] [Full Text] [Related]

  • 17. Purification and properties of a diisopropyl-fluorophosphatase from squid Todarodes pacificus steenstrup.
    Wang F, Xiao M, Mu S.
    J Biochem Toxicol; 1993 Sep 06; 8(3):161-6. PubMed ID: 8263902
    [Abstract] [Full Text] [Related]

  • 18. Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects.
    Sirivarasai J, Kaojarern S, Yoovathaworn K, Sura T.
    Chem Biol Interact; 2007 Jul 20; 168(3):184-92. PubMed ID: 17532308
    [Abstract] [Full Text] [Related]

  • 19. Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1.
    Valiyaveettil M, Alamneh Y, Biggemann L, Soojhawon I, Doctor BP, Nambiar MP.
    Biochem Biophys Res Commun; 2010 Dec 03; 403(1):97-102. PubMed ID: 21040699
    [Abstract] [Full Text] [Related]

  • 20. Characterization of P-S bond hydrolysis in organophosphorothioate pesticides by organophosphorus hydrolase.
    Lai K, Stolowich NJ, Wild JR.
    Arch Biochem Biophys; 1995 Apr 01; 318(1):59-64. PubMed ID: 7726573
    [Abstract] [Full Text] [Related]

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