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Journal Abstract Search

267 related items for PubMed ID: 18413761

  • 1. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3.
    Ahmad R, Raina D, Meyer C, Kufe D.
    Cancer Res; 2008 Apr 15; 68(8):2920-6. PubMed ID: 18413761
    [Abstract] [Full Text] [Related]

  • 2. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.
    Ling X, Konopleva M, Zeng Z, Ruvolo V, Stephens LC, Schober W, McQueen T, Dietrich M, Madden TL, Andreeff M.
    Cancer Res; 2007 May 01; 67(9):4210-8. PubMed ID: 17483332
    [Abstract] [Full Text] [Related]

  • 3. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway.
    Ryu K, Susa M, Choy E, Yang C, Hornicek FJ, Mankin HJ, Duan Z.
    BMC Cancer; 2010 May 10; 10():187. PubMed ID: 20459702
    [Abstract] [Full Text] [Related]

  • 4. Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
    Ahmad R, Raina D, Meyer C, Kharbanda S, Kufe D.
    J Biol Chem; 2006 Nov 24; 281(47):35764-9. PubMed ID: 16998237
    [Abstract] [Full Text] [Related]

  • 5. Bardoxolone Methyl Suppresses Hepatitis B Virus Large Surface Protein Variant W4P-Related Carcinogenesis and Hepatocellular Carcinoma Cell Proliferation Via the Inhibition of Signal Transducer and Activator of Transcription 3 Signaling.
    Gee MS, Kang SB, Kim N, Choi J, Kim NJ, Kim BJ, Inn KS, Lee JK.
    Pharmacology; 2018 Nov 24; 102(1-2):105-113. PubMed ID: 29953997
    [Abstract] [Full Text] [Related]

  • 6. Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma.
    Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Mankin H, Duan Z.
    Spine (Phila Pa 1976); 2010 Aug 15; 35(18):1668-75. PubMed ID: 20386502
    [Abstract] [Full Text] [Related]

  • 7. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
    Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB.
    Clin Cancer Res; 2006 Mar 15; 12(6):1828-38. PubMed ID: 16551868
    [Abstract] [Full Text] [Related]

  • 8. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells.
    Duan Z, Ames RY, Ryan M, Hornicek FJ, Mankin H, Seiden MV.
    Cancer Chemother Pharmacol; 2009 Mar 15; 63(4):681-9. PubMed ID: 18587580
    [Abstract] [Full Text] [Related]

  • 9. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.
    Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY.
    Cancer Res; 2004 Oct 15; 64(20):7570-8. PubMed ID: 15492284
    [Abstract] [Full Text] [Related]

  • 10. c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.
    Zou W, Chen S, Liu X, Yue P, Sporn MB, Khuri FR, Sun SY.
    Cancer Biol Ther; 2007 Oct 15; 6(10):1614-20. PubMed ID: 18253090
    [Abstract] [Full Text] [Related]

  • 11. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.
    Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L.
    J Biol Chem; 2010 Dec 24; 285(52):40581-92. PubMed ID: 20956520
    [Abstract] [Full Text] [Related]

  • 12. The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.
    Fitzpatrick LR, Stonesifer E, Small JS, Liby KT.
    Inflammopharmacology; 2014 Dec 24; 22(6):341-9. PubMed ID: 24715223
    [Abstract] [Full Text] [Related]

  • 13. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.
    Stadheim TA, Suh N, Ganju N, Sporn MB, Eastman A.
    J Biol Chem; 2002 May 10; 277(19):16448-55. PubMed ID: 11880365
    [Abstract] [Full Text] [Related]

  • 14. Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).
    Yue P, Zhou Z, Khuri FR, Sun SY.
    Cancer Biol Ther; 2006 May 10; 5(5):492-7. PubMed ID: 16582599
    [Abstract] [Full Text] [Related]

  • 15. Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.
    Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S.
    Mol Pharmacol; 2010 Aug 10; 78(2):226-36. PubMed ID: 20488920
    [Abstract] [Full Text] [Related]

  • 16. Telomerase reverse transcriptase (TERT) is a therapeutic target of oleanane triterpenoid CDDO-Me in prostate cancer.
    Liu Y, Gao X, Deeb D, Arbab AS, Gautam SC.
    Molecules; 2012 Dec 11; 17(12):14795-809. PubMed ID: 23519253
    [Abstract] [Full Text] [Related]

  • 17. Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
    Liby K, Risingsong R, Royce DB, Williams CR, Yore MM, Honda T, Gribble GW, Lamph WW, Vannini N, Sogno I, Albini A, Sporn MB.
    Clin Cancer Res; 2008 Jul 15; 14(14):4556-63. PubMed ID: 18628471
    [Abstract] [Full Text] [Related]

  • 18. Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer.
    Hyer ML, Shi R, Krajewska M, Meyer C, Lebedeva IV, Fisher PB, Reed JC.
    Cancer Res; 2008 Apr 15; 68(8):2927-33. PubMed ID: 18413762
    [Abstract] [Full Text] [Related]

  • 19. Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells.
    Liu Y, Gao X, Deeb D, Gautam SC.
    Biochem Biophys Res Commun; 2012 Jan 06; 417(1):570-5. PubMed ID: 22177954
    [Abstract] [Full Text] [Related]

  • 20. CDDO-me induces apoptosis and inhibits Akt, mTOR and NF-kappaB signaling proteins in prostate cancer cells.
    Deeb D, Gao X, Dulchavsky SA, Gautam SC.
    Anticancer Res; 2007 Jan 06; 27(5A):3035-44. PubMed ID: 17970042
    [Abstract] [Full Text] [Related]

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