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Journal Abstract Search

297 related items for PubMed ID: 18420145

  • 1. Structure-based design of a superagonist ligand for the vitamin D nuclear receptor.
    Hourai S, Rodrigues LC, Antony P, Reina-San-Martin B, Ciesielski F, Magnier BC, Schoonjans K, Mouriño A, Rochel N, Moras D.
    Chem Biol; 2008 Apr; 15(4):383-92. PubMed ID: 18420145
    [Abstract] [Full Text] [Related]

  • 2. Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3.
    Antony P, Sigüeiro R, Huet T, Sato Y, Ramalanjaona N, Rodrigues LC, Mouriño A, Moras D, Rochel N.
    J Med Chem; 2010 Feb 11; 53(3):1159-71. PubMed ID: 20070104
    [Abstract] [Full Text] [Related]

  • 3. Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification.
    Tocchini-Valentini G, Rochel N, Wurtz JM, Moras D.
    J Med Chem; 2004 Apr 08; 47(8):1956-61. PubMed ID: 15055995
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains.
    Fraga R, Zacconi F, Sussman F, Ordóñez-Morán P, Muñoz A, Huet T, Molnár F, Moras D, Rochel N, Maestro M, Mouriño A.
    Chemistry; 2012 Jan 09; 18(2):603-12. PubMed ID: 22162241
    [Abstract] [Full Text] [Related]

  • 5. Therapeutic applications for novel non-hypercalcemic vitamin D receptor ligands.
    Choi M, Makishima M.
    Expert Opin Ther Pat; 2009 May 09; 19(5):593-606. PubMed ID: 19441936
    [Abstract] [Full Text] [Related]

  • 6. Structural evaluation of the agonistic action of a vitamin D analog with two side chains binding to the nuclear vitamin D receptor.
    Väisänen S, Peräkylä M, Kärkkäinen JI, Uskokovic MR, Carlberg C.
    Mol Pharmacol; 2003 Jun 09; 63(6):1230-7. PubMed ID: 12761332
    [Abstract] [Full Text] [Related]

  • 7. Analogs of 1alpha,25-dihydroxyvitamin D3 with high potency in induction of osteoclastogenesis and prevention of dendritic cell differentiation: synthesis and biological evaluation of 2-substituted 19-norvitamin D analogs.
    Shimazaki M, Miyamoto Y, Yamamoto K, Yamada S, Takami M, Shinki T, Udagawa N, Shimizu M.
    Bioorg Med Chem; 2006 Jul 01; 14(13):4645-56. PubMed ID: 16513359
    [Abstract] [Full Text] [Related]

  • 8. 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure.
    Shimizu M, Miyamoto Y, Takaku H, Matsuo M, Nakabayashi M, Masuno H, Udagawa N, DeLuca HF, Ikura T, Ito N.
    Bioorg Med Chem; 2008 Jul 15; 16(14):6949-64. PubMed ID: 18539034
    [Abstract] [Full Text] [Related]

  • 9. 1 alpha,25-Dihydroxyvitamin D(3) is a preventive factor in the metastasis of lung cancer.
    Nakagawa K, Kawaura A, Kato S, Takeda E, Okano T.
    Carcinogenesis; 2005 Feb 15; 26(2):429-40. PubMed ID: 15539405
    [Abstract] [Full Text] [Related]

  • 10. Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.
    Eelen G, Verlinden L, Rochel N, Claessens F, De Clercq P, Vandewalle M, Tocchini-Valentini G, Moras D, Bouillon R, Verstuyf A.
    Mol Pharmacol; 2005 May 15; 67(5):1566-73. PubMed ID: 15728261
    [Abstract] [Full Text] [Related]

  • 11. Structure-function relationships of vitamin D including ligand recognition by the vitamin D receptor.
    Yamada S, Shimizu M, Yamamoto K.
    Med Res Rev; 2003 Jan 15; 23(1):89-115. PubMed ID: 12424754
    [Abstract] [Full Text] [Related]

  • 12. Crystal structure of a vitamin D3 analog, ZK203278, showing dissociated profile.
    Rochel N, Moras D.
    Anticancer Res; 2012 Jan 15; 32(1):335-9. PubMed ID: 22213324
    [Abstract] [Full Text] [Related]

  • 13. Novel 1alpha,25-dihydroxyvitamin D3 analogues with the side chain at C12.
    González-Avión XC, Mouriño A, Rochel N, Moras D.
    J Med Chem; 2006 Mar 09; 49(5):1509-16. PubMed ID: 16509569
    [Abstract] [Full Text] [Related]

  • 14. Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide.
    Vanhooke JL, Benning MM, Bauer CB, Pike JW, DeLuca HF.
    Biochemistry; 2004 Apr 13; 43(14):4101-10. PubMed ID: 15065852
    [Abstract] [Full Text] [Related]

  • 15. Characterization of five 19-nor-analogs of 1alpha,25(OH)2-Vitamin D3 with 20-cyclopropyl-modified side-chains: implications for ligand binding and calcemic properties.
    Olivera CJ, Bula CM, Bishop JE, Adorini L, Manchand P, Uskokovic MR, Norman AW.
    J Steroid Biochem Mol Biol; 2004 May 13; 89-90(1-5):99-106. PubMed ID: 15225754
    [Abstract] [Full Text] [Related]

  • 16. Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol.
    Rochel N, Hourai S, Pérez-García X, Rumbo A, Mourino A, Moras D.
    Arch Biochem Biophys; 2007 Apr 15; 460(2):172-6. PubMed ID: 17346665
    [Abstract] [Full Text] [Related]

  • 17. Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential.
    Gocek E, Kiełbiński M, Wyłób P, Kutner A, Marcinkowska E.
    Steroids; 2008 Dec 22; 73(14):1359-66. PubMed ID: 18644400
    [Abstract] [Full Text] [Related]

  • 18. Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3).
    Norman AW, Adams D, Collins ED, Okamura WH, Fletterick RJ.
    J Cell Biochem; 1999 Sep 01; 74(3):323-33. PubMed ID: 10412035
    [Abstract] [Full Text] [Related]

  • 19. A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor.
    Inaba Y, Yoshimoto N, Sakamaki Y, Nakabayashi M, Ikura T, Tamamura H, Ito N, Shimizu M, Yamamoto K.
    J Med Chem; 2009 Mar 12; 52(5):1438-49. PubMed ID: 19193059
    [Abstract] [Full Text] [Related]

  • 20. Vitamin D receptor ligands for osteoporosis.
    Cheskis BJ, Freedman LP, Nagpal S.
    Curr Opin Investig Drugs; 2006 Oct 12; 7(10):906-11. PubMed ID: 17086935
    [Abstract] [Full Text] [Related]

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