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Journal Abstract Search

104 related items for PubMed ID: 18445230

  • 1. Down-regulation of insulin-degrading enzyme by presenilin 1 V97L mutant potentially underlies increased levels of amyloid beta 42.
    Qin W, Jia J.
    Eur J Neurosci; 2008 May; 27(9):2425-32. PubMed ID: 18445230
    [Abstract] [Full Text] [Related]

  • 2. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
    [Abstract] [Full Text] [Related]

  • 3. Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
    Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.
    J Alzheimers Dis; 2009 Mar; 16(3):565-75. PubMed ID: 19276551
    [Abstract] [Full Text] [Related]

  • 4. Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.
    Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H.
    Neurosci Lett; 2008 Jun 20; 438(2):216-20. PubMed ID: 18455870
    [Abstract] [Full Text] [Related]

  • 5. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
    Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.
    Biochemistry; 2005 May 03; 44(17):6513-25. PubMed ID: 15850385
    [Abstract] [Full Text] [Related]

  • 6. Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study.
    Bora RP, Prabhakar R.
    Biochemistry; 2010 May 11; 49(18):3947-56. PubMed ID: 20380468
    [Abstract] [Full Text] [Related]

  • 7. [The effect of two newly Chinese presenilin-1 mutations on the sensitivity to trophic factor withdrawal in human neuroblastoma cells].
    Fang BY, Jia JP.
    Zhonghua Yi Xue Za Zhi; 2007 Jan 30; 87(5):336-40. PubMed ID: 17456364
    [Abstract] [Full Text] [Related]

  • 8. Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.
    Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.
    Cell Calcium; 2006 Jun 30; 39(6):539-50. PubMed ID: 16620965
    [Abstract] [Full Text] [Related]

  • 9. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease.
    Zhao Z, Xiang Z, Haroutunian V, Buxbaum JD, Stetka B, Pasinetti GM.
    Neurobiol Aging; 2007 Jun 30; 28(6):824-30. PubMed ID: 16769157
    [Abstract] [Full Text] [Related]

  • 10. Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.
    Blomqvist ME, Chalmers K, Andreasen N, Bogdanovic N, Wilcock GK, Cairns NJ, Feuk L, Brookes AJ, Love S, Blennow K, Kehoe PG, Prince JA.
    Neurobiol Aging; 2005 Jun 30; 26(6):795-802. PubMed ID: 15718037
    [Abstract] [Full Text] [Related]

  • 11. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
    Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE.
    J Exp Biol; 2009 Feb 30; 212(Pt 4):494-8. PubMed ID: 19181896
    [Abstract] [Full Text] [Related]

  • 12. Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.
    Fang B, Jia L, Jia J.
    Neurosci Lett; 2006 Oct 02; 406(1-2):33-7. PubMed ID: 16916581
    [Abstract] [Full Text] [Related]

  • 13. Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane.
    Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Chonabayashi K, Shibasaki H, Shimohama S.
    J Neurosci Res; 2003 Oct 15; 74(2):184-91. PubMed ID: 14515347
    [Abstract] [Full Text] [Related]

  • 14. Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila.
    Tsuda M, Kobayashi T, Matsuo T, Aigaki T.
    FEBS Lett; 2010 Jul 02; 584(13):2916-20. PubMed ID: 20493190
    [Abstract] [Full Text] [Related]

  • 15. Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42.
    Duering M, Grimm MO, Grimm HS, Schröder J, Hartmann T.
    Neurobiol Aging; 2005 Jun 02; 26(6):785-8. PubMed ID: 15718035
    [Abstract] [Full Text] [Related]

  • 16. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures.
    Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE.
    J Neurosci Res; 2006 May 15; 83(7):1262-70. PubMed ID: 16511862
    [Abstract] [Full Text] [Related]

  • 17. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
    Lin HC, Hsieh HM, Chen YH, Hu ML.
    Neurotoxicology; 2009 Jul 15; 30(4):622-7. PubMed ID: 19635394
    [Abstract] [Full Text] [Related]

  • 18. Cytosolic amyloid-beta peptide 42 escaping from degradation induces cell death.
    Lee EK, Park YW, Shin DY, Mook-Jung I, Yoo YJ.
    Biochem Biophys Res Commun; 2006 Jun 02; 344(2):471-7. PubMed ID: 16630565
    [Abstract] [Full Text] [Related]

  • 19. miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation.
    Wang X, Liu P, Zhu H, Xu Y, Ma C, Dai X, Huang L, Liu Y, Zhang L, Qin C.
    Brain Res Bull; 2009 Oct 28; 80(4-5):268-73. PubMed ID: 19683563
    [Abstract] [Full Text] [Related]

  • 20. Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease.
    Zuo X, Jia J.
    Brain Res; 2009 Jan 16; 1249():1-8. PubMed ID: 18996360
    [Abstract] [Full Text] [Related]

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