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72 related items for PubMed ID: 18456871

  • 1. Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability.
    Wang W, Prosise WW, Chen J, Taremi SS, Le HV, Madison V, Cui X, Thomas A, Cheng KC, Lesburg CA.
    Protein Eng Des Sel; 2008 Jul; 21(7):425-33. PubMed ID: 18456871
    [Abstract] [Full Text] [Related]

  • 2. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor.
    Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR.
    J Mol Biol; 2003 Aug 22; 331(4):815-28. PubMed ID: 12909012
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR.
    Xiao L, Nickbarg E, Wang W, Thomas A, Ziebell M, Prosise WW, Lesburg CA, Taremi SS, Gerlach VL, Le HV, Cheng KC.
    Biochem Pharmacol; 2011 Mar 01; 81(5):669-79. PubMed ID: 21145880
    [Abstract] [Full Text] [Related]

  • 4. RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis.
    Kammerer S, Germain P, Flaig R, Peluso-Iltis C, Mitschler A, Rochel N, Gronemeyer H, Moras D.
    Acta Crystallogr D Biol Crystallogr; 2004 Nov 01; 60(Pt 11):2048-50. PubMed ID: 15502323
    [Abstract] [Full Text] [Related]

  • 5. Using intrinsic fluorescence emission spectroscopy to study steroid receptor and coactivator protein conformation dynamics.
    Watt K, McEwan IJ.
    Methods Mol Biol; 2009 Nov 01; 505():205-18. PubMed ID: 19117147
    [Abstract] [Full Text] [Related]

  • 6. Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR.
    Khan JA, Camac DM, Low S, Tebben AJ, Wensel DL, Wright MC, Su J, Jenny V, Gupta RD, Ruzanov M, Russo KA, Bell A, An Y, Bryson JW, Gao M, Gambhire P, Baldwin ET, Gardner D, Cavallaro CL, Duncia JV, Hynes J.
    J Mol Biol; 2015 Feb 27; 427(4):924-942. PubMed ID: 25579995
    [Abstract] [Full Text] [Related]

  • 7. Functional characterization of the native NH2-terminal transactivation domain of the human androgen receptor: binding kinetics for interactions with TFIIF and SRC-1a.
    Lavery DN, McEwan IJ.
    Biochemistry; 2008 Mar 18; 47(11):3352-9. PubMed ID: 18284209
    [Abstract] [Full Text] [Related]

  • 8. Structural model reveals key interactions in the assembly of the pregnane X receptor/corepressor complex.
    Wang CY, Li CW, Chen JD, Welsh WJ.
    Mol Pharmacol; 2006 May 18; 69(5):1513-7. PubMed ID: 16452398
    [Abstract] [Full Text] [Related]

  • 9. Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.
    Wang H, Huang H, Li H, Teotico DG, Sinz M, Baker SD, Staudinger J, Kalpana G, Redinbo MR, Mani S.
    Clin Cancer Res; 2007 Apr 15; 13(8):2488-95. PubMed ID: 17438109
    [Abstract] [Full Text] [Related]

  • 10. Small-angle X-ray scattering studies on structures of an estrogen-related receptor alpha ligand binding domain and its complexes with ligands and coactivators.
    Jin KS, Park JK, Yoon J, Rho Y, Kim JH, Kim EE, Ree M.
    J Phys Chem B; 2008 Aug 14; 112(32):9603-12. PubMed ID: 18646811
    [Abstract] [Full Text] [Related]

  • 11. Human PXR forms a tryptophan zipper-mediated homodimer.
    Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR.
    Biochemistry; 2006 Jul 18; 45(28):8579-89. PubMed ID: 16834332
    [Abstract] [Full Text] [Related]

  • 12. A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.
    Moreau A, Téruel C, Beylot M, Albalea V, Tamasi V, Umbdenstock T, Parmentier Y, Sa-Cunha A, Suc B, Fabre JM, Navarro F, Ramos J, Meyer U, Maurel P, Vilarem MJ, Pascussi JM.
    Hepatology; 2009 Jun 18; 49(6):2068-79. PubMed ID: 19437491
    [Abstract] [Full Text] [Related]

  • 13. [Coexpression of PXRLBD with SRC88 and construction of equilibrium dialysis model of screening PXR ligands].
    Ye SS, Yu CN, Chen J, Sun HY, Chen SQ.
    Yao Xue Xue Bao; 2008 Apr 18; 43(4):427-30. PubMed ID: 18664208
    [Abstract] [Full Text] [Related]

  • 14. Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer.
    Gupta D, Venkatesh M, Wang H, Kim S, Sinz M, Goldberg GL, Whitney K, Longley C, Mani S.
    Clin Cancer Res; 2008 Sep 01; 14(17):5332-40. PubMed ID: 18765524
    [Abstract] [Full Text] [Related]

  • 15. Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor.
    Kojetin DJ, Burris TP, Jensen EV, Khan SA.
    Endocr Relat Cancer; 2008 Dec 01; 15(4):851-70. PubMed ID: 18755852
    [Abstract] [Full Text] [Related]

  • 16. Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins.
    Navaratnarajah P, Steele BL, Redinbo MR, Thompson NL.
    Biochemistry; 2012 Jan 10; 51(1):19-31. PubMed ID: 22185585
    [Abstract] [Full Text] [Related]

  • 17. Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.
    Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR.
    Bioorg Med Chem; 2007 Mar 01; 15(5):2156-66. PubMed ID: 17215127
    [Abstract] [Full Text] [Related]

  • 18. Co-activator SRC-1 is dispensable for transcriptional control by STAT3.
    Cvijic H, Bauer K, Löffler D, Pfeifer G, Blumert C, Kretzschmar AK, Henze C, Brocke-Heidrich K, Horn F.
    Biochem J; 2009 Apr 28; 420(1):123-32. PubMed ID: 19203349
    [Abstract] [Full Text] [Related]

  • 19. Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.
    Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR.
    Mol Endocrinol; 2007 May 28; 21(5):1028-38. PubMed ID: 17327420
    [Abstract] [Full Text] [Related]

  • 20. Impairment in protein expression profile of testicular steroid receptor coregulators in male rat offspring perinatally exposed to Bisphenol A.
    Salian S, Doshi T, Vanage G.
    Life Sci; 2009 Jul 03; 85(1-2):11-8. PubMed ID: 19379760
    [Abstract] [Full Text] [Related]

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