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287 related items for PubMed ID: 18466334

  • 1. Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.
    Malik B, Currais A, Soriano S.
    J Neurochem; 2008 Jul; 106(2):912-6. PubMed ID: 18466334
    [Abstract] [Full Text] [Related]

  • 2. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.
    Exp Neurol; 2004 Aug; 188(2):224-37. PubMed ID: 15246822
    [Abstract] [Full Text] [Related]

  • 3. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 4. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA.
    J Neurochem; 2006 Mar 15; 96(5):1322-35. PubMed ID: 16478525
    [Abstract] [Full Text] [Related]

  • 5. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar 15; 57(3):446-53. PubMed ID: 17210196
    [Abstract] [Full Text] [Related]

  • 6. Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis.
    Benussi L, Alberici A, Mayhaus M, Langer U, Ghidoni R, Mazzoli F, Nicosia F, Barbiero L, Frisoni G, Zanetti O, Gasparini L, Nitsch RM, Binetti G.
    Exp Cell Res; 2001 Oct 01; 269(2):256-65. PubMed ID: 11570818
    [Abstract] [Full Text] [Related]

  • 7. Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.
    White AR, Guirguis R, Brazier MW, Jobling MF, Hill AF, Beyreuther K, Barrow CJ, Masters CL, Collins SJ, Cappai R.
    Neurobiol Dis; 2001 Apr 01; 8(2):299-316. PubMed ID: 11300725
    [Abstract] [Full Text] [Related]

  • 8. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 01; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 9. The presenilin 1 C92S mutation increases abeta 42 production.
    Lewis PA, Perez-Tur J, Golde TE, Hardy J.
    Biochem Biophys Res Commun; 2000 Oct 14; 277(1):261-3. PubMed ID: 11027672
    [Abstract] [Full Text] [Related]

  • 10. TGF-beta1 is increased in a transgenic mouse model of familial Alzheimer's disease and causes neuronal apoptosis.
    Salins P, He Y, Olson K, Glazner G, Kashour T, Amara F.
    Neurosci Lett; 2008 Jan 03; 430(1):81-6. PubMed ID: 18063474
    [Abstract] [Full Text] [Related]

  • 11. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.
    Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T.
    Biochem Biophys Res Commun; 1998 Mar 27; 244(3):751-5. PubMed ID: 9535737
    [Abstract] [Full Text] [Related]

  • 12. Different fibrillar Abeta 1-42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle.
    Majd S, Zarifkar A, Rastegar K, Takhshid MA.
    Brain Res; 2008 Jul 07; 1218():224-9. PubMed ID: 18533137
    [Abstract] [Full Text] [Related]

  • 13. Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1/A246E mouse model of autosomal dominant Alzheimer's disease: correlations with behavior and oxidative stress.
    Strazielle C, Jazi R, Verdier Y, Qian S, Lalonde R.
    Neurochem Int; 2009 Dec 07; 55(8):806-14. PubMed ID: 19682525
    [Abstract] [Full Text] [Related]

  • 14. Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis.
    Wang R, Dineley KT, Sweatt JD, Zheng H.
    Neuroscience; 2004 Dec 07; 126(2):305-12. PubMed ID: 15207348
    [Abstract] [Full Text] [Related]

  • 15. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
    Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE.
    J Exp Biol; 2009 Feb 07; 212(Pt 4):494-8. PubMed ID: 19181896
    [Abstract] [Full Text] [Related]

  • 16. Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.
    Leschik J, Welzel A, Weissmann C, Eckert A, Brandt R.
    J Neurochem; 2007 Jun 07; 101(5):1303-15. PubMed ID: 17298384
    [Abstract] [Full Text] [Related]

  • 17. Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer's disease [amyloid precursor protein/presenilin 1 (PS1)].
    Esteras N, Bartolomé F, Alquézar C, Antequera D, Muñoz Ú, Carro E, Martín-Requero Á.
    Eur J Neurosci; 2012 Sep 07; 36(5):2609-18. PubMed ID: 22702220
    [Abstract] [Full Text] [Related]

  • 18. Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.
    Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.
    Cell Calcium; 2006 Jun 07; 39(6):539-50. PubMed ID: 16620965
    [Abstract] [Full Text] [Related]

  • 19. Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains.
    Amritraj A, Hawkes C, Phinney AL, Mount HT, Scott CD, Westaway D, Kar S.
    Neurobiol Aging; 2009 Jan 07; 30(1):54-70. PubMed ID: 17561313
    [Abstract] [Full Text] [Related]

  • 20. Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.
    Ramalho RM, Borralho PM, Castro RE, Solá S, Steer CJ, Rodrigues CM.
    J Neurochem; 2006 Sep 07; 98(5):1610-8. PubMed ID: 16923170
    [Abstract] [Full Text] [Related]

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