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Journal Abstract Search

209 related items for PubMed ID: 18474675

  • 1. Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes.
    Bae SK, Cao S, Seo KA, Kim H, Kim MJ, Shon JH, Liu KH, Zhou HH, Shin JG.
    Drug Metab Dispos; 2008 Aug; 36(8):1679-88. PubMed ID: 18474675
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  • 4. Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism.
    Pan W, Bae SK, Shim EJ, Park SE, Lee SS, Park SJ, Yeo CW, Zhou HH, Shon JH, Shin JG.
    Xenobiotica; 2013 Feb; 43(2):211-8. PubMed ID: 22830954
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  • 6. Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects.
    Shinde DD, Kim HS, Choi JS, Pan W, Bae SK, Yeo CW, Shon JH, Kim DH, Shin JG.
    J Clin Pharmacol; 2013 May; 53(5):550-8. PubMed ID: 23381968
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  • 7. Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine.
    Richter T, Mürdter TE, Heinkele G, Pleiss J, Tatzel S, Schwab M, Eichelbaum M, Zanger UM.
    J Pharmacol Exp Ther; 2004 Jan; 308(1):189-97. PubMed ID: 14563790
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  • 9. The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity.
    Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, Desta Z.
    J Pharmacol Exp Ther; 2003 Jul; 306(1):287-300. PubMed ID: 12676886
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  • 10. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
    Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A.
    Drug Metab Dispos; 2010 Jan; 38(1):92-9. PubMed ID: 19812348
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  • 12. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
    Niwa T, Shiraga T, Mitani Y, Terakawa M, Tokuma Y, Kagayama A.
    Drug Metab Dispos; 2000 Sep; 28(9):1128-34. PubMed ID: 10950860
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  • 14. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
    Ramírez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ.
    Drug Metab Dispos; 2004 Sep; 32(9):930-6. PubMed ID: 15319333
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  • 15. Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro.
    Turpeinen M, Nieminen R, Juntunen T, Taavitsainen P, Raunio H, Pelkonen O.
    Drug Metab Dispos; 2004 Jun; 32(6):626-31. PubMed ID: 15155554
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  • 16. Role of human CYP2B6 in S-mephobarbital N-demethylation.
    Kobayashi K, Abe S, Nakajima M, Shimada N, Tani M, Chiba K, Yamamoto T.
    Drug Metab Dispos; 1999 Dec; 27(12):1429-33. PubMed ID: 10570024
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  • 17. Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4.
    Casabar RC, Wallace AD, Hodgson E, Rose RL.
    Drug Metab Dispos; 2006 Oct; 34(10):1779-85. PubMed ID: 16855053
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  • 20. Stereo-selective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: a reconciliation.
    Chang Y, Fang WB, Lin SN, Moody DE.
    Basic Clin Pharmacol Toxicol; 2011 Jan; 108(1):55-62. PubMed ID: 20825389
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