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173 related items for PubMed ID: 18474678

  • 1. Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes.
    Grime K, Webborn PJ, Riley RJ.
    Drug Metab Dispos; 2008 Aug; 36(8):1670-8. PubMed ID: 18474678
    [Abstract] [Full Text] [Related]

  • 2. Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: transporter-enzyme interplay.
    Brown HS, Wilby AJ, Alder J, Houston JB.
    Drug Metab Dispos; 2010 Dec; 38(12):2139-46. PubMed ID: 20847136
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.
    McGinnity DF, Berry AJ, Kenny JR, Grime K, Riley RJ.
    Drug Metab Dispos; 2006 Aug; 34(8):1291-300. PubMed ID: 16679385
    [Abstract] [Full Text] [Related]

  • 4. Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditions.
    Mao J, Mohutsky MA, Harrelson JP, Wrighton SA, Hall SD.
    Drug Metab Dispos; 2012 Apr; 40(4):706-16. PubMed ID: 22228749
    [Abstract] [Full Text] [Related]

  • 5. Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions.
    McGinnity DF, Waters NJ, Tucker J, Riley RJ.
    Drug Metab Dispos; 2008 Jun; 36(6):1126-34. PubMed ID: 18356267
    [Abstract] [Full Text] [Related]

  • 6. Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination.
    Brown HS, Chadwick A, Houston JB.
    Drug Metab Dispos; 2007 Nov; 35(11):2119-26. PubMed ID: 17724064
    [Abstract] [Full Text] [Related]

  • 7. Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes.
    Paine SW, Parker AJ, Gardiner P, Webborn PJ, Riley RJ.
    Drug Metab Dispos; 2008 Jul; 36(7):1365-74. PubMed ID: 18426955
    [Abstract] [Full Text] [Related]

  • 8. Characterization of human liver cytochrome P450 enzymes involved in the metabolism of a new H+/K+-ATPase inhibitor KR-60436.
    Ji HY, Lee HW, Kim HH, Choi JK, Lee HS.
    Toxicol Lett; 2005 Jan 15; 155(1):103-14. PubMed ID: 15585365
    [Abstract] [Full Text] [Related]

  • 9. Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes.
    Kimoto E, Walsky R, Zhang H, Bi YA, Whalen KM, Yang YS, Linder C, Xiao Y, Iseki K, Fenner KS, El-Kattan AF, Lai Y.
    Drug Metab Dispos; 2012 Feb 15; 40(2):407-11. PubMed ID: 22031626
    [Abstract] [Full Text] [Related]

  • 10. Effect of atorvastatin and fluvastatin on the metabolism of midazolam by cytochrome P450 in vitro.
    Mc Donnell CG, Shorten G, Van Pelt FN.
    Anaesthesia; 2005 Aug 15; 60(8):747-53. PubMed ID: 16029222
    [Abstract] [Full Text] [Related]

  • 11. A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.
    Lu C, Miwa GT, Prakash SR, Gan LS, Balani SK.
    Drug Metab Dispos; 2007 Jan 15; 35(1):79-85. PubMed ID: 17020957
    [Abstract] [Full Text] [Related]

  • 12. Farnesol as an inhibitor and substrate for rabbit liver microsomal P450 enzymes.
    Raner GM, Muir AQ, Lowry CW, Davis BA.
    Biochem Biophys Res Commun; 2002 Apr 26; 293(1):1-6. PubMed ID: 12054554
    [Abstract] [Full Text] [Related]

  • 13. Predicting metabolic clearance for drugs that are actively transported into hepatocytes: incubational binding as a consequence of in vitro hepatocyte concentration is a key factor.
    Nordell P, Svanberg P, Bird J, Grime K.
    Drug Metab Dispos; 2013 Apr 26; 41(4):836-43. PubMed ID: 23364509
    [Abstract] [Full Text] [Related]

  • 14. Lenalidomide: in vitro evaluation of the metabolism and assessment of cytochrome P450 inhibition and induction.
    Kumar G, Lau H, Laskin O.
    Cancer Chemother Pharmacol; 2009 May 26; 63(6):1171-5. PubMed ID: 19030860
    [Abstract] [Full Text] [Related]

  • 15. Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. II. In vitro-in vivo correlation with ketoconazole.
    Lu C, Hatsis P, Berg C, Lee FW, Balani SK.
    Drug Metab Dispos; 2008 Jul 26; 36(7):1255-60. PubMed ID: 18381489
    [Abstract] [Full Text] [Related]

  • 16. Correlation between in vivo and in vitro hepatic uptake of metabolic inhibitors of cytochrome P-450 in rats.
    Yamano K, Yamamoto K, Kotaki H, Takedomi S, Matsuo H, Sawada Y, Iga T.
    Drug Metab Dispos; 1999 Nov 26; 27(11):1225-31. PubMed ID: 10534305
    [Abstract] [Full Text] [Related]

  • 17. Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance.
    Hallifax D, Houston JB.
    Drug Metab Dispos; 2006 Nov 26; 34(11):1829-36. PubMed ID: 16882765
    [Abstract] [Full Text] [Related]

  • 18. Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.
    Weaver R, Graham KS, Beattie IG, Riley RJ.
    Drug Metab Dispos; 2003 Jul 26; 31(7):955-66. PubMed ID: 12814974
    [Abstract] [Full Text] [Related]

  • 19. Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.
    Stringer RA, Strain-Damerell C, Nicklin P, Houston JB.
    Drug Metab Dispos; 2009 May 26; 37(5):1025-34. PubMed ID: 19196847
    [Abstract] [Full Text] [Related]

  • 20. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems.
    Lau YY, Okochi H, Huang Y, Benet LZ.
    J Pharmacol Exp Ther; 2006 Feb 26; 316(2):762-71. PubMed ID: 16258024
    [Abstract] [Full Text] [Related]

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