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Journal Abstract Search

181 related items for PubMed ID: 18489177

  • 1. Total synthesis of the Hsp90 inhibitor geldanamycin.
    Qin HL, Panek JS.
    Org Lett; 2008 Jun 19; 10(12):2477-9. PubMed ID: 18489177
    [Abstract] [Full Text] [Related]

  • 2. Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.
    McErlean CS, Proisy N, Davis CJ, Boland NA, Sharp SY, Boxall K, Slawin AM, Workman P, Moody CJ.
    Org Biomol Chem; 2007 Feb 07; 5(3):531-46. PubMed ID: 17252137
    [Abstract] [Full Text] [Related]

  • 3. Total synthesis of herbimycin A.
    Canova S, Bellosta V, Bigot A, Mailliet P, Mignani S, Cossy J.
    Org Lett; 2007 Jan 04; 9(1):145-8. PubMed ID: 17192106
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.
    Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon YJ, Park JT, Bang JS, Lee HS, Kim TY, Lee JJ, Hong YS.
    Org Biomol Chem; 2008 Jan 21; 6(2):340-8. PubMed ID: 18175003
    [Abstract] [Full Text] [Related]

  • 5. Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor.
    Jeso V, Cherry L, Macklin TK, Pan SC, LoGrasso PV, Micalizio GC.
    Org Lett; 2011 Oct 07; 13(19):5108-11. PubMed ID: 21866939
    [Abstract] [Full Text] [Related]

  • 6. Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.
    Wrona IE, Gozman A, Taldone T, Chiosis G, Panek JS.
    J Org Chem; 2010 May 07; 75(9):2820-35. PubMed ID: 20392070
    [Abstract] [Full Text] [Related]

  • 7. Heat shock protein 90: inhibitors in clinical trials.
    Biamonte MA, Van de Water R, Arndt JW, Scannevin RH, Perret D, Lee WC.
    J Med Chem; 2010 Jan 14; 53(1):3-17. PubMed ID: 20055425
    [No Abstract] [Full Text] [Related]

  • 8. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
    Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ.
    J Med Chem; 2006 Jul 27; 49(15):4606-15. PubMed ID: 16854066
    [Abstract] [Full Text] [Related]

  • 9. An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.
    Kitson RR, Moody CJ.
    Chem Commun (Camb); 2013 Oct 04; 49(76):8441-3. PubMed ID: 23770604
    [Abstract] [Full Text] [Related]

  • 10. Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.
    Kitson RR, Moody CJ.
    J Org Chem; 2013 Jun 07; 78(11):5117-41. PubMed ID: 23496136
    [Abstract] [Full Text] [Related]

  • 11. The missing C-17 O-methyltransferase in geldanamycin biosynthesis.
    Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B.
    Org Lett; 2011 Jul 15; 13(14):3726-9. PubMed ID: 21682254
    [Abstract] [Full Text] [Related]

  • 12. Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.
    Franke J, Eichner S, Zeilinger C, Kirschning A.
    Nat Prod Rep; 2013 Oct 11; 30(10):1299-323. PubMed ID: 23934201
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.
    Li YP, Chen JJ, Shen JJ, Cui J, Wu LZ, Wang Z, Li ZR.
    Cancer Chemother Pharmacol; 2015 Apr 11; 75(4):773-82. PubMed ID: 25681003
    [Abstract] [Full Text] [Related]

  • 14. Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.
    Li Z, Jia L, Wang J, Wu X, Hao H, Wu Y, Xu H, Wang Z, Shi G, Lu C, Shen Y.
    Eur J Med Chem; 2014 Nov 24; 87():346-63. PubMed ID: 25277067
    [Abstract] [Full Text] [Related]

  • 15. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
    Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ.
    Nat Chem; 2013 Apr 24; 5(4):307-14. PubMed ID: 23511419
    [Abstract] [Full Text] [Related]

  • 16. Geldanamycin-inspired compounds induce direct trans-differentiation of human mesenchymal stem cells to neurons.
    Jogula S, Soorneedi AR, Gaddam J, Chamakuri S, Deora GS, Indarapu RK, Ramgopal MK, Dravida S, Arya P.
    Eur J Med Chem; 2017 Jul 28; 135():110-116. PubMed ID: 28441579
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.
    Li Z, Jia L, Wang J, Wu X, Hao H, Xu H, Wu Y, Shi G, Lu C, Shen Y.
    Eur J Med Chem; 2014 Oct 06; 85():359-70. PubMed ID: 25105924
    [Abstract] [Full Text] [Related]

  • 18. In vitro and in vivo Evaluation of 17-phenylpropylamine/phenoxyethylamine- 17-demethoxygeldanamycins as Potent Hsp90 Inhibitors.
    Li Z, Jia L, Xu H, Lu C, Shena Y.
    Med Chem; 2015 Oct 06; 11(5):482-8. PubMed ID: 25537129
    [Abstract] [Full Text] [Related]

  • 19. Molecular characterization of macbecin as an Hsp90 inhibitor.
    Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.
    J Med Chem; 2008 May 08; 51(9):2853-7. PubMed ID: 18357975
    [Abstract] [Full Text] [Related]

  • 20. New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus.
    Wu CZ, Moon AN, Jang JH, Lee D, Kang SY, Park JT, Ahn JS, Hwang BY, Kim YH, Lee HS, Hong YS.
    J Antibiot (Tokyo); 2011 Jun 08; 64(6):461-3. PubMed ID: 21448187
    [No Abstract] [Full Text] [Related]

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