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Journal Abstract Search

278 related items for PubMed ID: 18495157

  • 1. Intense neutral drifts yield robust and evolvable consensus proteins.
    Bershtein S, Goldin K, Tawfik DS.
    J Mol Biol; 2008 Jun 20; 379(5):1029-44. PubMed ID: 18495157
    [Abstract] [Full Text] [Related]

  • 2. Increased folding stability of TEM-1 beta-lactamase by in vitro selection.
    Kather I, Jakob RP, Dobbek H, Schmid FX.
    J Mol Biol; 2008 Oct 31; 383(1):238-51. PubMed ID: 18706424
    [Abstract] [Full Text] [Related]

  • 3. Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts.
    Bershtein S, Tawfik DS.
    Mol Biol Evol; 2008 Nov 31; 25(11):2311-8. PubMed ID: 18687656
    [Abstract] [Full Text] [Related]

  • 4. Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.
    Bershtein S, Segal M, Bekerman R, Tokuriki N, Tawfik DS.
    Nature; 2006 Dec 14; 444(7121):929-32. PubMed ID: 17122770
    [Abstract] [Full Text] [Related]

  • 5. Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.
    Orencia MC, Yoon JS, Ness JE, Stemmer WP, Stevens RC.
    Nat Struct Biol; 2001 Mar 14; 8(3):238-42. PubMed ID: 11224569
    [Abstract] [Full Text] [Related]

  • 6. Natural selection for kinetic stability is a likely origin of correlations between mutational effects on protein energetics and frequencies of amino acid occurrences in sequence alignments.
    Godoy-Ruiz R, Ariza F, Rodriguez-Larrea D, Perez-Jimenez R, Ibarra-Molero B, Sanchez-Ruiz JM.
    J Mol Biol; 2006 Oct 06; 362(5):966-78. PubMed ID: 16935299
    [Abstract] [Full Text] [Related]

  • 7. Directed enzyme evolution via small and effective neutral drift libraries.
    Gupta RD, Tawfik DS.
    Nat Methods; 2008 Nov 06; 5(11):939-42. PubMed ID: 18931667
    [Abstract] [Full Text] [Related]

  • 8. Sequence-function-stability relationships in proteins from datasets of functionally annotated variants: the case of TEM β-lactamases.
    Abriata LA, Salverda ML, Tomatis PE.
    FEBS Lett; 2012 Sep 21; 586(19):3330-5. PubMed ID: 22850115
    [Abstract] [Full Text] [Related]

  • 9. Construction of stabilized proteins by combinatorial consensus mutagenesis.
    Amin N, Liu AD, Ramer S, Aehle W, Meijer D, Metin M, Wong S, Gualfetti P, Schellenberger V.
    Protein Eng Des Sel; 2004 Nov 21; 17(11):787-93. PubMed ID: 15574484
    [Abstract] [Full Text] [Related]

  • 10. The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase.
    Zaccolo M, Gherardi E.
    J Mol Biol; 1999 Jan 15; 285(2):775-83. PubMed ID: 9878443
    [Abstract] [Full Text] [Related]

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  • 12. A general method of terminal truncation, evolution, and re-elongation to generate enzymes of enhanced stability.
    Hecky J, Mason JM, Arndt KM, Müller KM.
    Methods Mol Biol; 2007 Jan 15; 352():275-304. PubMed ID: 17041271
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  • 14. Structural perturbation and compensation by directed evolution at physiological temperature leads to thermostabilization of beta-lactamase.
    Hecky J, Müller KM.
    Biochemistry; 2005 Sep 27; 44(38):12640-54. PubMed ID: 16171379
    [Abstract] [Full Text] [Related]

  • 15. Neutral evolution of proteins: The superfunnel in sequence space and its relation to mutational robustness.
    Noirel J, Simonson T.
    J Chem Phys; 2008 Nov 14; 129(18):185104. PubMed ID: 19045432
    [Abstract] [Full Text] [Related]

  • 16. Biocatalysts by evolution.
    Jäckel C, Hilvert D.
    Curr Opin Biotechnol; 2010 Dec 14; 21(6):753-9. PubMed ID: 20850962
    [Abstract] [Full Text] [Related]

  • 17. Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.
    Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS.
    Biochemistry; 2009 Jul 21; 48(28):6644-54. PubMed ID: 19492856
    [Abstract] [Full Text] [Related]

  • 18. Protein design through systematic catalytic loop exchange in the (beta/alpha)8 fold.
    Ochoa-Leyva A, Soberón X, Sánchez F, Argüello M, Montero-Morán G, Saab-Rincón G.
    J Mol Biol; 2009 Apr 10; 387(4):949-64. PubMed ID: 19233201
    [Abstract] [Full Text] [Related]

  • 19. Exploring the molecular linkage of protein stability traits for enzyme optimization by iterative truncation and evolution.
    Speck J, Hecky J, Tam HK, Arndt KM, Einsle O, Müller KM.
    Biochemistry; 2012 Jun 19; 51(24):4850-67. PubMed ID: 22545913
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