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232 related items for PubMed ID: 18501591
1. 1alpha,25-Dihydroxyvitamin D(3)-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells. Ishizuka S, Kurihara N, Hiruma Y, Miura D, Namekawa J, Tamura A, Kato-Nakamura Y, Nakano Y, Takenouchi K, Hashimoto Y, Nagasawa K, Roodman GD. J Steroid Biochem Mol Biol; 2008 Jun; 110(3-5):269-77. PubMed ID: 18501591 [Abstract] [Full Text] [Related]
2. Novel vitamin D3 analogs, 1alpha, 25(OH)2D(3)-26, 23-lactam (DLAMs), antagonize bone resorption via suppressing RANKL expression in osteoblasts. Inada M, Tsukamoto K, Hirata M, Takita M, Nagasawa K, Miyaura C. Biochem Biophys Res Commun; 2008 Aug 01; 372(3):434-9. PubMed ID: 18489902 [Abstract] [Full Text] [Related]
3. Antagonistic action of novel 1alpha,25-dihydroxyvitamin D3-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1alpha,25-dihydroxyvitamin D3. Miura D, Manabe K, Ozono K, Saito M, Gao Q, Norman AW, Ishizuka S. J Biol Chem; 1999 Jun 04; 274(23):16392-9. PubMed ID: 10347199 [Abstract] [Full Text] [Related]
4. Synthesis of 1alpha,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist. Kato Y, Nakano Y, Sano H, Tanatani A, Kobayashi H, Shimazawa R, Koshino H, Hashimoto Y, Nagasawa K. Bioorg Med Chem Lett; 2004 May 17; 14(10):2579-83. PubMed ID: 15109656 [Abstract] [Full Text] [Related]
5. (23S)-25-Dehydro-1{alpha}-hydroxyvitamin D3-26,23-lactone, a vitamin D receptor antagonist that inhibits osteoclast formation and bone resorption in bone marrow cultures from patients with Paget's disease. Ishizuka S, Kurihara N, Reddy SV, Cornish J, Cundy T, Roodman GD. Endocrinology; 2005 Apr 17; 146(4):2023-30. PubMed ID: 15618361 [Abstract] [Full Text] [Related]
6. (23S)- and (23R)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic actions of 1alpha,25-dihydroxyvitamin D(3). Ishizuka S, Miura D, Ozono K, Saito M, Eguchi H, Chokki M, Norman AW. Steroids; 2001 Apr 17; 66(3-5):227-37. PubMed ID: 11179730 [Abstract] [Full Text] [Related]
7. Antagonistic action of novel 1alpha,25-dihydroxyvitamin D(3)-26, 23-lactone analogs on 25-hydroxyvitamin-D(3)-24-hydroxylase gene expression induced by 1alpha,25-dihydroxy-vitamin D(3) in human promyelocytic leukemia (HL-60) cells. Ishizuka S, Miura D, Eguchi H, Ozono K, Chokki M, Kamimura T, Norman AW. Arch Biochem Biophys; 2000 Aug 01; 380(1):92-102. PubMed ID: 10900137 [Abstract] [Full Text] [Related]
8. Structure-activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist. Cho K, Uneuchi F, Kato-Nakamura Y, Namekawa J, Ishizuka S, Takenouchi K, Nagasawa K. Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4287-90. PubMed ID: 18635349 [Abstract] [Full Text] [Related]
9. Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis. Nakano Y, Kato Y, Imai K, Ochiai E, Namekawa J, Ishizuka S, Takenouchi K, Tanatani A, Hashimoto Y, Nagasawa K. J Med Chem; 2006 Apr 20; 49(8):2398-406. PubMed ID: 16610783 [Abstract] [Full Text] [Related]
10. 1alpha,25-dihydroxyvitamin D(3)-26,23-lactone analogs antagonize differentiation of human leukemia cells (HL-60 cells) but not of human acute promyelocytic leukemia cells (NB4 cells). Miura D, Manabe K, Gao Q, Norman AW, Ishizuka S. FEBS Lett; 1999 Oct 29; 460(2):297-302. PubMed ID: 10544253 [Abstract] [Full Text] [Related]
11. Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1alpha,25-dihydroxyvitamin D3 from pagetic bone marrow cells. Ishizuka S, Kurihara N, Miura D, Takenouchi K, Cornish J, Cundy T, Reddy SV, Roodman GD. J Steroid Biochem Mol Biol; 2004 May 29; 89-90(1-5):331-4. PubMed ID: 15225795 [Abstract] [Full Text] [Related]
12. Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells. Iwaki M, Kanemoto Y, Sawada T, Nojiri K, Kurokawa T, Tsutsumi R, Nagasawa K, Kato S. PLoS One; 2023 May 29; 18(12):e0295288. PubMed ID: 38091304 [Abstract] [Full Text] [Related]
13. Synthetic studies of (23S,25R)-1α,25-dihydroxyvitamin D3 26,23-lactone (calcitriol lactone) and its derivatives. Akagi Y, Nagata A, Odagi M, Nagasawa K. J Steroid Biochem Mol Biol; 2018 Mar 29; 177():240-246. PubMed ID: 28757443 [Abstract] [Full Text] [Related]
14. Singly dehydroxylated A-ring analogues of 19-nor-1alpha,25-dihydroxyvitamin D3 and 19-nor-22-oxa-1alpha,25-dihydroxyvitamin D3: novel vitamin D3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor. Okano T, Nakagawa K, Tsugawa N, Ozono K, Kubodera N, Osawa A, Terada M, Mikami K. Biol Pharm Bull; 1998 Dec 29; 21(12):1300-5. PubMed ID: 9881643 [Abstract] [Full Text] [Related]
15. Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D(3): transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells. Nakagawa K, Kurobe M, Ozono K, Konno K, Fujishima T, Takayama H, Okano T. Biochem Pharmacol; 2000 Mar 15; 59(6):691-702. PubMed ID: 10677586 [Abstract] [Full Text] [Related]
16. 25-Dehydro-1alpha-hydroxyvitamin D3-26,23S-lactone antagonizes the nuclear vitamin D receptor by mediating a unique noncovalent conformational change. Bula CM, Bishop JE, Ishizuka S, Norman AW. Mol Endocrinol; 2000 Nov 15; 14(11):1788-96. PubMed ID: 11075812 [Abstract] [Full Text] [Related]
17. Mechanistic studies to evaluate the enhanced antiproliferation of human keratinocytes by 1alpha,25-dihydroxyvitamin D(3)-3-bromoacetate, a covalent modifier of vitamin D receptor, compared to 1alpha,25-dihydroxyvitamin D(3). Chen ML, Ray S, Swamy N, Holick MF, Ray R. Arch Biochem Biophys; 1999 Oct 01; 370(1):34-44. PubMed ID: 10496974 [Abstract] [Full Text] [Related]
18. Natural metabolites of 1alpha,25-dihydroxyvitamin D(3) retain biologic activity mediated through the vitamin D receptor. Harant H, Spinner D, Reddy GS, Lindley IJ. J Cell Biochem; 2000 Apr 01; 78(1):112-20. PubMed ID: 10797570 [Abstract] [Full Text] [Related]
19. The 3-epi- and 24-oxo-derivatives of 1alpha,25 dihydroxyvitamin D(3) stimulate transcription through the vitamin D receptor. Messerlian S, Gao X, St-Arnaud R. J Steroid Biochem Mol Biol; 2000 Apr 01; 72(1-2):29-34. PubMed ID: 10731635 [Abstract] [Full Text] [Related]
20. Antagonistic Actions in Vivo of (23S)-25-Dehydro-1alpha-Hydroxyvitamin D(3-)26,23-Lactone on Calcium Metabolism Induced by 1alpha,25-Dihydroxyvitamin D(3). Ishizuka S, Miura D, Ozono K, Chokki M, Mimura H, Norman AW. Endocrinology; 2001 Jan 01; 142(1):59-67. PubMed ID: 11145567 [Abstract] [Full Text] [Related] Page: [Next] [New Search]