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Journal Abstract Search

191 related items for PubMed ID: 18502828

  • 21. A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia.
    Marín-Ramos NI, Balabasquer M, Ortega-Nogales FJ, Torrecillas IR, Gil-Ordóñez A, Marcos-Ramiro B, Aguilar-Garrido P, Cushman I, Romero A, Medrano FJ, Gajate C, Mollinedo F, Philips MR, Campillo M, Gallardo M, Martín-Fontecha M, López-Rodríguez ML, Ortega-Gutiérrez S.
    J Med Chem; 2019 Jul 11; 62(13):6035-6046. PubMed ID: 31181882
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  • 22. Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.
    Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M.
    Mol Cancer Ther; 2017 May 11; 16(5):914-923. PubMed ID: 28167504
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  • 23. In silico Exploration of a Novel ICMT Inhibitor with More Solubility than Cysmethynil against Membrane Localization of KRAS Mutant in Colorectal Cancer.
    Mouhcine M, Kadil Y, Segmani I, Rahmoune I, Filali H.
    Curr Comput Aided Drug Des; 2024 May 11; 20(7):1055-1069. PubMed ID: 38835128
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  • 24. The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors.
    Anderson JL, Henriksen BS, Gibbs RA, Hrycyna CA.
    J Biol Chem; 2005 Aug 19; 280(33):29454-61. PubMed ID: 15946942
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  • 25. Isoprenylcysteine carboxyl methyltransferase (ICMT) promotes invadopodia formation and metastasis in cancer cells.
    Borini Etichetti C, Arel Zalazar E, Di Benedetto C, Cocordano N, Valente S, Bicciato S, Menacho-Márquez M, Larocca MC, Girardini J.
    Biochimie; 2024 Jul 19; 222():28-36. PubMed ID: 38301884
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  • 26. Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor.
    Borini Etichetti C, Di Benedetto C, Rossi C, Baglioni MV, Bicciato S, Del Sal G, Menacho-Marquez M, Girardini J.
    J Biol Chem; 2019 Mar 29; 294(13):5060-5073. PubMed ID: 30655292
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  • 27. Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt).
    Baron RA, Casey PJ.
    BMC Biochem; 2004 Dec 29; 5():19. PubMed ID: 15625008
    [Abstract] [Full Text] [Related]

  • 28. Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms.
    Lau HY, Tang J, Casey PJ, Wang M.
    Oncogene; 2017 Jul 06; 36(27):3934-3942. PubMed ID: 28192404
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  • 29. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT).
    Judd WR, Slattum PM, Hoang KC, Bhoite L, Valppu L, Alberts G, Brown B, Roth B, Ostanin K, Huang L, Wettstein D, Richards B, Willardsen JA.
    J Med Chem; 2011 Jul 28; 54(14):5031-47. PubMed ID: 21661760
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  • 38. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis.
    Kong G, Chang YI, Damnernsawad A, You X, Du J, Ranheim EA, Lee W, Ryu MJ, Zhou Y, Xing Y, Chang Q, Burd CE, Zhang J.
    Leukemia; 2016 Jul 28; 30(7):1542-51. PubMed ID: 27055865
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  • 39. Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.
    Yang J, Kulkarni K, Manolaridis I, Zhang Z, Dodd RB, Mas-Droux C, Barford D.
    Mol Cell; 2011 Dec 23; 44(6):997-1004. PubMed ID: 22195972
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  • 40. Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.
    Bergman JA, Hahne K, Hrycyna CA, Gibbs RA.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5616-9. PubMed ID: 21782433
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