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Journal Abstract Search

345 related items for PubMed ID: 18507369

  • 1. Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide.
    Choi SK, Green D, Ho A, Klein U, Marquess D, Taylor R, Turner SD.
    J Med Chem; 2008 Jun 26; 51(12):3609-16. PubMed ID: 18507369
    [Abstract] [Full Text] [Related]

  • 2. Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation.
    Law H, Dukat M, Teitler M, Lee DK, Mazzocco L, Kamboj R, Rampersad V, Prisinzano T, Glennon RA.
    J Med Chem; 1998 Jun 18; 41(13):2243-51. PubMed ID: 9632357
    [Abstract] [Full Text] [Related]

  • 3. 5-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein.
    Cohen ML, Schenck K.
    J Pharmacol Exp Ther; 1999 Sep 18; 290(3):935-9. PubMed ID: 10454462
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.
    Sternfeld F, Guiblin AR, Jelley RA, Matassa VG, Reeve AJ, Hunt PA, Beer MS, Heald A, Stanton JA, Sohal B, Watt AP, Street LJ.
    J Med Chem; 1999 Feb 25; 42(4):677-90. PubMed ID: 10052975
    [Abstract] [Full Text] [Related]

  • 5. 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
    Chambers MS, Street LJ, Goodacre S, Hobbs SC, Hunt P, Jelley RA, Matassa VG, Reeve AJ, Sternfeld F, Beer MS, Stanton JA, Rathbone D, Watt AP, MacLeod AM.
    J Med Chem; 1999 Feb 25; 42(4):691-705. PubMed ID: 10052976
    [Abstract] [Full Text] [Related]

  • 6. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
    Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML.
    J Med Chem; 2009 Apr 23; 52(8):2384-92. PubMed ID: 19326916
    [Abstract] [Full Text] [Related]

  • 7. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist.
    Ahlgren C, Eriksson A, Tellefors P, Ross SB, Stenfors C, Malmberg A.
    Eur J Pharmacol; 2004 Sep 19; 499(1-2):67-75. PubMed ID: 15363952
    [Abstract] [Full Text] [Related]

  • 8. F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine.
    John GW, Pauwels PJ, Perez M, Halazy S, Le Grand B, Verscheure Y, Valentin JP, Palmier C, Wurch T, Chopin P, Marien M, Kleven MS, Koek W, Assie MB, Carilla-Durand E, Tarayre JP, Colpaert FC.
    J Pharmacol Exp Ther; 1999 Jul 19; 290(1):83-95. PubMed ID: 10381763
    [Abstract] [Full Text] [Related]

  • 9. 2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.
    Prisinzano T, Dukat M, Law H, Slassi A, MacLean N, DeLannoy I, Glennon RA.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4697-9. PubMed ID: 15324890
    [Abstract] [Full Text] [Related]

  • 10. Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists.
    Halazy S, Perez M, Fourrier C, Pallard I, Pauwels PJ, Palmier C, John GW, Valentin JP, Bonnafous R, Martinez J.
    J Med Chem; 1996 Dec 06; 39(25):4920-7. PubMed ID: 8960551
    [Abstract] [Full Text] [Related]

  • 11. 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.
    Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Böttcher H.
    J Med Chem; 2000 Mar 23; 43(6):1149-57. PubMed ID: 10737747
    [Abstract] [Full Text] [Related]

  • 12. The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
    Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Hatcher J, Jones BJ, Middlemiss DN, Price GW, Riley G, Roberts C, Routledge C, Selkirk J, Slade PD.
    J Med Chem; 1998 Apr 09; 41(8):1218-35. PubMed ID: 9548813
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and serotonergic activity of substituted 2, N-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N, N-dimethyltryptamine derivatives: novel antagonists for the vascular 5-HT(1B)-like receptor.
    Moloney GP, Martin GR, Mathews N, Milne A, Hobbs H, Dodsworth S, Sang PY, Knight C, Williams M, Maxwell M, Glen RC.
    J Med Chem; 1999 Jul 15; 42(14):2504-26. PubMed ID: 10411472
    [Abstract] [Full Text] [Related]

  • 14. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo M, Berardi F, Colabufo NA, Contino M, Lacivita E, Niso M, Perrone R, Tortorella V.
    J Med Chem; 2004 Dec 16; 47(26):6616-24. PubMed ID: 15588097
    [Abstract] [Full Text] [Related]

  • 15. N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.
    Xu YC, Johnson KW, Phebus LA, Cohen M, Nelson DL, Schenck K, Walker CD, Fritz JE, Kaldor SW, LeTourneau ME, Murff RE, Zgombick JM, Calligaro DO, Audia JE, Schaus JM.
    J Med Chem; 2001 Nov 22; 44(24):4031-4. PubMed ID: 11708905
    [Abstract] [Full Text] [Related]

  • 16. 5-Hydroxytryptamine1B receptor-mediated contraction of rabbit saphenous vein and basilar artery: role of vascular endothelium.
    Bhattacharya A, Schenck KW, Xu YC, Nisenbaum L, Galbreath E, Cohen ML.
    J Pharmacol Exp Ther; 2004 May 22; 309(2):825-32. PubMed ID: 14724223
    [Abstract] [Full Text] [Related]

  • 17. Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.
    van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL.
    J Med Chem; 1999 Jun 17; 42(12):2087-104. PubMed ID: 10377215
    [Abstract] [Full Text] [Related]

  • 18. 3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators.
    Bernotas RC, Antane S, Shenoy R, Le VD, Chen P, Harrison BL, Robichaud AJ, Zhang GM, Smith D, Schechter LE.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1657-60. PubMed ID: 20138763
    [Abstract] [Full Text] [Related]

  • 19. Distribution of 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor expression in rat trigeminal and dorsal root ganglia neurons: relevance to the selective anti-migraine effect of triptans.
    Classey JD, Bartsch T, Goadsby PJ.
    Brain Res; 2010 Nov 18; 1361():76-85. PubMed ID: 20833155
    [Abstract] [Full Text] [Related]

  • 20. APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology.
    Adams JW, Ramirez J, Shi Y, Thomsen W, Frazer J, Morgan M, Edwards JE, Chen W, Teegarden BR, Xiong Y, Al-Shamma H, Behan DP, Connolly DT.
    J Pharmacol Exp Ther; 2009 Oct 18; 331(1):96-103. PubMed ID: 19628629
    [Abstract] [Full Text] [Related]

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