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Journal Abstract Search

348 related items for PubMed ID: 18511276

  • 1. Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
    Ye XY, Li YX, Farrelly D, Flynn N, Gu L, Locke KT, Lippy J, O'Malley K, Twamley C, Zhang L, Ryono DE, Zahler R, Hariharan N, Cheng PT.
    Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3545-50. PubMed ID: 18511276
    [Abstract] [Full Text] [Related]

  • 2. Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
    Pingali H, Jain M, Shah S, Makadia P, Zaware P, Goel A, Patel M, Giri S, Patel H, Patel P.
    Bioorg Med Chem; 2008 Aug 01; 16(15):7117-27. PubMed ID: 18625559
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  • 3. Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
    Zhang H, Ryono DE, Devasthale P, Wang W, O'Malley K, Farrelly D, Gu L, Harrity T, Cap M, Chu C, Locke K, Zhang L, Lippy J, Kunselman L, Morgan N, Flynn N, Moore L, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Doweyko AM, Bell A, Chang C, Muckelbauer J, Zahler R, Hariharan N, Cheng PT.
    Bioorg Med Chem Lett; 2009 Mar 01; 19(5):1451-6. PubMed ID: 19201606
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  • 4. Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.
    Kuhn B, Hilpert H, Benz J, Binggeli A, Grether U, Humm R, Märki HP, Meyer M, Mohr P.
    Bioorg Med Chem Lett; 2006 Aug 01; 16(15):4016-20. PubMed ID: 16737814
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  • 6. Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
    Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ.
    J Med Chem; 2008 Oct 23; 51(20):6318-33. PubMed ID: 18826205
    [Abstract] [Full Text] [Related]

  • 7. Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.
    Shi GQ, Dropinski JF, Zhang Y, Santini C, Sahoo SP, Berger JP, Macnaul KL, Zhou G, Agrawal A, Alvaro R, Cai TQ, Hernandez M, Wright SD, Moller DE, Heck JV, Meinke PT.
    J Med Chem; 2005 Aug 25; 48(17):5589-99. PubMed ID: 16107159
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  • 10. Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists.
    Gim HJ, Cheon YJ, Ryu JH, Jeon R.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):3057-61. PubMed ID: 21482466
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  • 11. Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.
    Devasthale PV, Chen S, Jeon Y, Qu F, Ryono DE, Wang W, Zhang H, Cheng L, Farrelly D, Golla R, Grover G, Ma Z, Moore L, Seethala R, Sun W, Doweyko AM, Chandrasena G, Sleph P, Hariharan N, Cheng PT.
    Bioorg Med Chem Lett; 2007 Apr 15; 17(8):2312-6. PubMed ID: 17292606
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  • 12. Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists.
    Grether U, Bénardeau A, Benz J, Binggeli A, Blum D, Hilpert H, Kuhn B, Märki HP, Meyer M, Mohr P, Püntener K, Raab S, Ruf A, Schlatter D.
    ChemMedChem; 2009 Jun 15; 4(6):951-6. PubMed ID: 19326383
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  • 13. Synthesis, in vitro and in silico evaluation of l-tyrosine containing PPARalpha/gamma dual agonists.
    Kumar R, Ramachandran U, Khanna S, Bharatam PV, Raichur S, Chakrabarti R.
    Bioorg Med Chem; 2007 Feb 01; 15(3):1547-55. PubMed ID: 17166722
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  • 14. Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
    Fracchiolla G, Laghezza A, Piemontese L, Parente M, Lavecchia A, Pochetti G, Montanari R, Di Giovanni C, Carbonara G, Tortorella P, Novellino E, Loiodice F.
    Bioorg Med Chem; 2012 Mar 15; 20(6):2141-51. PubMed ID: 22341573
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  • 15. Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification.
    Zaware P, Shah SR, Pingali H, Makadia P, Thube B, Pola S, Patel D, Priyadarshini P, Suthar D, Shah M, Jamili J, Sairam KV, Giri S, Patel L, Patel H, Sudani H, Patel H, Jain M, Patel P, Bahekar R.
    Bioorg Med Chem Lett; 2011 Jan 15; 21(2):628-32. PubMed ID: 21195611
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  • 16. The discovery of equipotent PPARalpha/gamma dual activators.
    Martres P, Faucher N, Laroze A, Pineau O, Fouchet MH, Potvain F, Grillot D, Beneton V.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6251-4. PubMed ID: 18947994
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  • 18. Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
    Bénardeau A, Benz J, Binggeli A, Blum D, Boehringer M, Grether U, Hilpert H, Kuhn B, Märki HP, Meyer M, Püntener K, Raab S, Ruf A, Schlatter D, Mohr P.
    Bioorg Med Chem Lett; 2009 May 01; 19(9):2468-73. PubMed ID: 19349176
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  • 20. Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
    Humphries PS, Almaden JV, Barnum SJ, Carlson TJ, Do QQ, Fraser JD, Hess M, Kim YH, Ogilvie KM, Sun S.
    Bioorg Med Chem Lett; 2006 Dec 01; 16(23):6116-9. PubMed ID: 16979341
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