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Journal Abstract Search

124 related items for PubMed ID: 18515099

  • 1. Design, synthesis, and structure-activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine.
    Yoshizumi T, Miyazoe H, Ito H, Tsujita T, Takahashi H, Asai M, Ozaki S, Ohta H, Okamoto O.
    Bioorg Med Chem Lett; 2008 Jul 01; 18(13):3778-82. PubMed ID: 18515099
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  • 2. Discovery of novel arylpyrazole series as potent and selective opioid receptor-like 1 (ORL1) antagonists.
    Kobayashi K, Uchiyama M, Ito H, Takahashi H, Yoshizumi T, Sakoh H, Nagatomi Y, Asai M, Miyazoe H, Tsujita T, Hirayama M, Ozaki S, Tani T, Ishii Y, Ohta H, Okamoto O.
    Bioorg Med Chem Lett; 2009 Jul 01; 19(13):3627-31. PubMed ID: 19447610
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  • 3. Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
    Goto Y, Arai-Otsuki S, Tachibana Y, Ichikawa D, Ozaki S, Takahashi H, Iwasawa Y, Okamoto O, Okuda S, Ohta H, Sagara T.
    J Med Chem; 2006 Feb 09; 49(3):847-9. PubMed ID: 16451050
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  • 7. Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile.
    Ceccarelli SM, Pinard E, Stalder H, Alberati D.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):354-7. PubMed ID: 16246561
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  • 10. Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
    Caldwell JP, Matasi JJ, Fernandez X, McLeod RL, Zhang H, Fawzi A, Tulshian DB.
    Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1164-7. PubMed ID: 19147350
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  • 13. Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives.
    Hayashi S, Ohashi K, Mihara S, Nakata E, Emoto C, Ohta A.
    Eur J Med Chem; 2016 May 23; 114():345-64. PubMed ID: 27043173
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  • 15. Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.
    Trapella C, Fischetti C, Pela' M, Lazzari I, Guerrini R, Calo' G, Rizzi A, Camarda V, Lambert DG, McDonald J, Regoli D, Salvadori S.
    Bioorg Med Chem; 2009 Jul 15; 17(14):5080-95. PubMed ID: 19527931
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  • 17. High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
    Röver S, Adam G, Cesura AM, Galley G, Jenck F, Monsma FJ, Wichmann J, Dautzenberg FM.
    J Med Chem; 2000 Apr 06; 43(7):1329-38. PubMed ID: 10753470
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  • 19. Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists.
    Okano M, Mito J, Maruyama Y, Masuda H, Niwa T, Nakagawa S, Nakamura Y, Matsuura A.
    Bioorg Med Chem; 2009 Jan 01; 17(1):119-32. PubMed ID: 19041249
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