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309 related items for PubMed ID: 18517260

  • 1. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
    Wen X, Sun H, Liu J, Cheng K, Zhang P, Zhang L, Hao J, Zhang L, Ni P, Zographos SE, Leonidas DD, Alexacou KM, Gimisis T, Hayes JM, Oikonomakos NG.
    J Med Chem; 2008 Jun 26; 51(12):3540-54. PubMed ID: 18517260
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.
    Zhang P, Hao J, Liu J, Lu Q, Sheng H, Zhang L, Sun H.
    J Nat Prod; 2009 Aug 26; 72(8):1414-8. PubMed ID: 19642687
    [Abstract] [Full Text] [Related]

  • 3. Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
    Chen J, Liu J, Zhang L, Wu G, Hua W, Wu X, Sun H.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):2915-9. PubMed ID: 16546381
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and biological evaluation of asiatic acid derivatives as inhibitors of glycogen phosphorylases.
    Zhang L, Chen J, Gong Y, Liu J, Zhang L, Hua W, Sun H.
    Chem Biodivers; 2009 Jun 01; 6(6):864-74. PubMed ID: 19551727
    [Abstract] [Full Text] [Related]

  • 5. Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase.
    Cheng K, Zhang P, Liu J, Xie J, Sun H.
    J Nat Prod; 2008 Nov 01; 71(11):1877-80. PubMed ID: 18847277
    [Abstract] [Full Text] [Related]

  • 6. Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site.
    Kristiansen M, Andersen B, Iversen LF, Westergaard N.
    J Med Chem; 2004 Jul 01; 47(14):3537-45. PubMed ID: 15214781
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biological evaluation of novel pyrazolo[4,3-b]oleanane derivatives as inhibitors of glycogen phosphorylase.
    Chen J, Gong Y, Liu J, Hua W, Zhang L, Sun H.
    Chem Biodivers; 2008 Jul 01; 5(7):1304-12. PubMed ID: 18649317
    [Abstract] [Full Text] [Related]

  • 8. Advances in glycogen phosphorylase inhibitor design.
    Oikonomakos NG, Somsák L.
    Curr Opin Investig Drugs; 2008 Apr 01; 9(4):379-95. PubMed ID: 18393105
    [Abstract] [Full Text] [Related]

  • 9. Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases.
    Wen X, Sun H, Liu J, Wu G, Zhang L, Wu X, Ni P.
    Bioorg Med Chem Lett; 2005 Nov 15; 15(22):4944-8. PubMed ID: 16169219
    [Abstract] [Full Text] [Related]

  • 10. Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.
    Oikonomakos NG, Tsitsanou KE, Zographos SE, Skamnaki VT, Goldmann S, Bischoff H.
    Protein Sci; 1999 Oct 15; 8(10):1930-45. PubMed ID: 10548038
    [Abstract] [Full Text] [Related]

  • 11. Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors.
    Wen X, Zhang P, Liu J, Zhang L, Wu X, Ni P, Sun H.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(3):722-6. PubMed ID: 16246555
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological evaluation of ambradiolic acid as an inhibitor of glycogen phosphorylase.
    Liu J, Zhang H, Zhu P, Wu X, Yao H, Ye W, Jiang J, Xu J.
    Fitoterapia; 2015 Jan 15; 100():50-5. PubMed ID: 25447165
    [Abstract] [Full Text] [Related]

  • 13. Pentacyclic triterpenes. Part 5: synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases.
    Wen X, Xia J, Cheng K, Zhang L, Zhang P, Liu J, Zhang L, Ni P, Sun H.
    Bioorg Med Chem Lett; 2007 Nov 01; 17(21):5777-82. PubMed ID: 17869102
    [Abstract] [Full Text] [Related]

  • 14. Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.
    Tsitsanou KE, Hayes JM, Keramioti M, Mamais M, Oikonomakos NG, Kato A, Leonidas DD, Zographos SE.
    Food Chem Toxicol; 2013 Nov 01; 61():14-27. PubMed ID: 23279842
    [Abstract] [Full Text] [Related]

  • 15. Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.
    Oikonomakos NG, Tiraidis C, Leonidas DD, Zographos SE, Kristiansen M, Jessen CU, Nørskov-Lauritsen L, Agius L.
    J Med Chem; 2006 Sep 21; 49(19):5687-701. PubMed ID: 16970395
    [Abstract] [Full Text] [Related]

  • 16. Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
    Thomson SA, Banker P, Bickett DM, Boucheron JA, Carter HL, Clancy DC, Cooper JP, Dickerson SH, Garrido DM, Nolte RT, Peat AJ, Sheckler LR, Sparks SM, Tavares FX, Wang L, Wang TY, Weiel JE.
    Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1177-82. PubMed ID: 19138846
    [Abstract] [Full Text] [Related]

  • 17. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors.
    Anderka O, Loenze P, Klabunde T, Dreyer MK, Defossa E, Wendt KU, Schmoll D.
    Biochemistry; 2008 Apr 22; 47(16):4683-91. PubMed ID: 18373353
    [Abstract] [Full Text] [Related]

  • 18. Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase.
    Cheng K, Liu J, Liu X, Li H, Sun H, Xie J.
    Carbohydr Res; 2009 May 12; 344(7):841-50. PubMed ID: 19269628
    [Abstract] [Full Text] [Related]

  • 19. 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
    Tsirkone VG, Tsoukala E, Lamprakis C, Manta S, Hayes JM, Skamnaki VT, Drakou C, Zographos SE, Komiotis D, Leonidas DD.
    Bioorg Med Chem; 2010 May 15; 18(10):3413-25. PubMed ID: 20430629
    [Abstract] [Full Text] [Related]

  • 20. Crystallographic and computational studies on 4-phenyl-N-(beta-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: comparison with alpha-D-glucose, N-acetyl-beta-D-glucopyranosylamine and N-benzoyl-N'-beta-D-glucopyranosyl urea binding.
    Alexacou KM, Hayes JM, Tiraidis C, Zographos SE, Leonidas DD, Chrysina ED, Archontis G, Oikonomakos NG, Paul JV, Varghese B, Loganathan D.
    Proteins; 2008 May 15; 71(3):1307-23. PubMed ID: 18041758
    [Abstract] [Full Text] [Related]

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