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696 related items for PubMed ID: 18550760

  • 1. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
    Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW.
    J Neurosci; 2008 Jun 11; 28(24):6182-95. PubMed ID: 18550760
    [Abstract] [Full Text] [Related]

  • 2. Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice.
    Gu X, Richman J, Langfelder P, Wang N, Zhang S, Bañez-Coronel M, Wang HB, Yang L, Ramanathan L, Deng L, Park CS, Choi CR, Cantle JP, Gao F, Gray M, Coppola G, Bates GP, Ranum LPW, Horvath S, Colwell CS, Yang XW.
    Neuron; 2022 Apr 06; 110(7):1173-1192.e7. PubMed ID: 35114102
    [Abstract] [Full Text] [Related]

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  • 4. N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice.
    Gu X, Cantle JP, Greiner ER, Lee CY, Barth AM, Gao F, Park CS, Zhang Z, Sandoval-Miller S, Zhang RL, Diamond M, Mody I, Coppola G, Yang XW.
    Neuron; 2015 Feb 18; 85(4):726-41. PubMed ID: 25661181
    [Abstract] [Full Text] [Related]

  • 5. Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington's disease.
    Estrada-Sánchez AM, Burroughs CL, Cavaliere S, Barton SJ, Chen S, Yang XW, Rebec GV.
    J Neurosci; 2015 Mar 11; 35(10):4440-51. PubMed ID: 25762686
    [Abstract] [Full Text] [Related]

  • 6. Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.
    Wang N, Gray M, Lu XH, Cantle JP, Holley SM, Greiner E, Gu X, Shirasaki D, Cepeda C, Li Y, Dong H, Levine MS, Yang XW.
    Nat Med; 2014 May 11; 20(5):536-41. PubMed ID: 24784230
    [Abstract] [Full Text] [Related]

  • 7. A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease.
    Yu-Taeger L, Petrasch-Parwez E, Osmand AP, Redensek A, Metzger S, Clemens LE, Park L, Howland D, Calaminus C, Gu X, Pichler B, Yang XW, Riess O, Nguyen HP.
    J Neurosci; 2012 Oct 31; 32(44):15426-38. PubMed ID: 23115180
    [Abstract] [Full Text] [Related]

  • 8. Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.
    Reddy PH, Charles V, Williams M, Miller G, Whetsell WO, Tagle DA.
    Philos Trans R Soc Lond B Biol Sci; 1999 Jun 29; 354(1386):1035-45. PubMed ID: 10434303
    [Abstract] [Full Text] [Related]

  • 9. Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
    Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM.
    J Neurosci; 2012 May 30; 32(22):7454-65. PubMed ID: 22649225
    [Abstract] [Full Text] [Related]

  • 10. Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.
    Wegrzynowicz M, Bichell TJ, Soares BD, Loth MK, McGlothan JS, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, Bowman AB.
    J Huntingtons Dis; 2015 May 30; 4(1):17-36. PubMed ID: 26333255
    [Abstract] [Full Text] [Related]

  • 11. Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.
    Rocher AB, Gubellini P, Merienne N, Boussicault L, Petit F, Gipchtein P, Jan C, Hantraye P, Brouillet E, Bonvento G.
    Neurobiol Dis; 2016 Feb 30; 86():131-9. PubMed ID: 26626081
    [Abstract] [Full Text] [Related]

  • 12. Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice.
    Petkau TL, Hill A, Connolly C, Lu G, Wagner P, Kosior N, Blanco J, Leavitt BR.
    Hum Mol Genet; 2019 May 15; 28(10):1661-1670. PubMed ID: 30624705
    [Abstract] [Full Text] [Related]

  • 13. Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
    Clemens LE, Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C, Eckert SH, Gaca J, Weiss A, Magg JC, Jansson EK, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP.
    Brain; 2015 Dec 15; 138(Pt 12):3632-53. PubMed ID: 26490331
    [Abstract] [Full Text] [Related]

  • 14. Lack of mutant huntingtin in cortical efferents improves behavioral inflexibility and corticostriatal dynamics in Huntington's disease mice.
    Estrada-Sánchez AM, Blake CL, Barton SJ, Howe AG, Rebec GV.
    J Neurophysiol; 2019 Dec 01; 122(6):2621-2629. PubMed ID: 31693428
    [Abstract] [Full Text] [Related]

  • 15. Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
    Kratter IH, Zahed H, Lau A, Tsvetkov AS, Daub AC, Weiberth KF, Gu X, Saudou F, Humbert S, Yang XW, Osmand A, Steffan JS, Masliah E, Finkbeiner S.
    J Clin Invest; 2016 Sep 01; 126(9):3585-97. PubMed ID: 27525439
    [Abstract] [Full Text] [Related]

  • 16. Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
    Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW.
    Neuron; 2009 Dec 24; 64(6):828-40. PubMed ID: 20064390
    [Abstract] [Full Text] [Related]

  • 17. Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.
    Lee CY, Cantle JP, Yang XW.
    FEBS J; 2013 Sep 24; 280(18):4382-94. PubMed ID: 23829302
    [Abstract] [Full Text] [Related]

  • 18. αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease.
    Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S.
    Hum Mol Genet; 2016 May 01; 25(9):1677-89. PubMed ID: 26920069
    [Abstract] [Full Text] [Related]

  • 19. Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
    Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.
    Neurobiol Dis; 2008 Jul 01; 31(1):80-8. PubMed ID: 18502655
    [Abstract] [Full Text] [Related]

  • 20. Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease.
    Spampanato J, Gu X, Yang XW, Mody I.
    Neuroscience; 2008 Dec 02; 157(3):606-20. PubMed ID: 18854207
    [Abstract] [Full Text] [Related]

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