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217 related items for PubMed ID: 18582559

  • 1. Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition.
    Cai YJ, Lu JJ, Zhu H, Xie H, Huang M, Lin LP, Zhang XW, Ding J.
    Free Radic Biol Med; 2008 Sep 01; 45(5):627-35. PubMed ID: 18582559
    [Abstract] [Full Text] [Related]

  • 2. Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase.
    Lu HR, Zhu H, Huang M, Chen Y, Cai YJ, Miao ZH, Zhang JS, Ding J.
    Mol Pharmacol; 2005 Oct 01; 68(4):983-94. PubMed ID: 16024664
    [Abstract] [Full Text] [Related]

  • 3. Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II.
    Kawiak A, Piosik J, Stasilojc G, Gwizdek-Wisniewska A, Marczak L, Stobiecki M, Bigda J, Lojkowska E.
    Toxicol Appl Pharmacol; 2007 Sep 15; 223(3):267-76. PubMed ID: 17618663
    [Abstract] [Full Text] [Related]

  • 4. Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.
    Li Y, Luan Y, Qi X, Li M, Gong L, Xue X, Wu X, Wu Y, Chen M, Xing G, Yao J, Ren J.
    Toxicol Sci; 2010 Dec 15; 118(2):435-43. PubMed ID: 20855424
    [Abstract] [Full Text] [Related]

  • 5. Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation.
    Meng LH, Ding J.
    Acta Pharmacol Sin; 2007 Sep 15; 28(9):1460-5. PubMed ID: 17723179
    [Abstract] [Full Text] [Related]

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  • 8. The role of nonhomologous DNA end joining, conservative homologous recombination, and single-strand annealing in the cell cycle-dependent repair of DNA double-strand breaks induced by H(2)O(2) in mammalian cells.
    Frankenberg-Schwager M, Becker M, Garg I, Pralle E, Wolf H, Frankenberg D.
    Radiat Res; 2008 Dec 15; 170(6):784-93. PubMed ID: 19138034
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  • 9. Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha.
    Wu X, Liang H, O'Hara KA, Yalowich JC, Hasinoff BB.
    Chem Res Toxicol; 2008 Feb 15; 21(2):483-93. PubMed ID: 18197631
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  • 11. Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ.
    Driessens N, Versteyhe S, Ghaddhab C, Burniat A, De Deken X, Van Sande J, Dumont JE, Miot F, Corvilain B.
    Endocr Relat Cancer; 2009 Sep 15; 16(3):845-56. PubMed ID: 19509065
    [Abstract] [Full Text] [Related]

  • 12. Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.
    Iwata S, Hori T, Sato N, Hirota K, Sasada T, Mitsui A, Hirakawa T, Yodoi J.
    J Immunol; 1997 Apr 01; 158(7):3108-17. PubMed ID: 9120263
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  • 13. A cysteine-reactive alkyl hydroquinone modifies topoisomerase IIα, enhances DNA breakage, and induces apoptosis in cancer cells.
    Lin TY, Huang CP, Au LC, Chang YW, Hu CY, Lin SB.
    Chem Res Toxicol; 2012 Nov 19; 25(11):2340-51. PubMed ID: 23088786
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  • 14. A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis.
    Chen Z, Liang X, Zhang H, Xie H, Liu J, Xu Y, Zhu W, Wang Y, Wang X, Tan S, Kuang D, Qian X.
    J Med Chem; 2010 Mar 25; 53(6):2589-600. PubMed ID: 20170164
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells.
    Yang SY, Jia XZ, Feng LY, Li SY, An GS, Ni JH, Jia HT.
    Biochem Pharmacol; 2009 Feb 01; 77(3):433-43. PubMed ID: 19014910
    [Abstract] [Full Text] [Related]

  • 16. Induction of bulk and c-myc P2 promoter-specific DNA damage by an anti-topoisomerase II agent salvicine is an early event leading to apoptosis in HL-60 cells.
    Meng L, Ding J.
    FEBS Lett; 2001 Jul 13; 501(1):59-64. PubMed ID: 11457456
    [Abstract] [Full Text] [Related]

  • 17. A superoxide anion generator, pyrogallol induces apoptosis in As4.1 cells through the depletion of intracellular GSH content.
    Park WH, Han YW, Kim SH, Kim SZ.
    Mutat Res; 2007 Jun 01; 619(1-2):81-92. PubMed ID: 17382355
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  • 18. The changes of intracellular H2O2 are an important factor maintaining mitochondria membrane potential of antimycin A-treated As4.1 juxtaglomerular cells.
    Han YW, Kim SZ, Kim SH, Park WH.
    Biochem Pharmacol; 2007 Mar 15; 73(6):863-72. PubMed ID: 17174941
    [Abstract] [Full Text] [Related]

  • 19. Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes.
    Meng LH, Zhang JS, Ding J.
    Biochem Pharmacol; 2001 Sep 15; 62(6):733-41. PubMed ID: 11551518
    [Abstract] [Full Text] [Related]

  • 20. Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death.
    Swift LP, Rephaeli A, Nudelman A, Phillips DR, Cutts SM.
    Cancer Res; 2006 May 01; 66(9):4863-71. PubMed ID: 16651442
    [Abstract] [Full Text] [Related]

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