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Journal Abstract Search

428 related items for PubMed ID: 18591380

  • 1. HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
    Rao R, Fiskus W, Yang Y, Lee P, Joshi R, Fernandez P, Mandawat A, Atadja P, Bradner JE, Bhalla K.
    Blood; 2008 Sep 01; 112(5):1886-93. PubMed ID: 18591380
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.
    Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumaraswamy S, Boyapalle S, Atadja P, Seto E, Bhalla K.
    J Biol Chem; 2005 Jul 22; 280(29):26729-34. PubMed ID: 15937340
    [Abstract] [Full Text] [Related]

  • 3. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.
    George P, Bali P, Annavarapu S, Scuto A, Fiskus W, Guo F, Sigua C, Sondarva G, Moscinski L, Atadja P, Bhalla K.
    Blood; 2005 Feb 15; 105(4):1768-76. PubMed ID: 15514006
    [Abstract] [Full Text] [Related]

  • 4. Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin.
    Guo F, Rocha K, Bali P, Pranpat M, Fiskus W, Boyapalle S, Kumaraswamy S, Balasis M, Greedy B, Armitage ES, Lawrence N, Bhalla K.
    Cancer Res; 2005 Nov 15; 65(22):10536-44. PubMed ID: 16288046
    [Abstract] [Full Text] [Related]

  • 5. Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.
    Fiskus W, Rao R, Fernandez P, Herger B, Yang Y, Chen J, Kolhe R, Mandawat A, Wang Y, Joshi R, Eaton K, Lee P, Atadja P, Peiper S, Bhalla K.
    Blood; 2008 Oct 01; 112(7):2896-905. PubMed ID: 18660379
    [Abstract] [Full Text] [Related]

  • 6. FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases.
    Yao Q, Nishiuchi R, Li Q, Kumar AR, Hudson WA, Kersey JH.
    Clin Cancer Res; 2003 Oct 01; 9(12):4483-93. PubMed ID: 14555522
    [Abstract] [Full Text] [Related]

  • 7. Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts.
    Nimmanapalli R, O'Bryan E, Bhalla K.
    Cancer Res; 2001 Mar 01; 61(5):1799-804. PubMed ID: 11280726
    [Abstract] [Full Text] [Related]

  • 8. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion.
    Yang Y, Rao R, Shen J, Tang Y, Fiskus W, Nechtman J, Atadja P, Bhalla K.
    Cancer Res; 2008 Jun 15; 68(12):4833-42. PubMed ID: 18559531
    [Abstract] [Full Text] [Related]

  • 9. Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.
    Rahmani M, Reese E, Dai Y, Bauer C, Kramer LB, Huang M, Jove R, Dent P, Grant S.
    Mol Pharmacol; 2005 Apr 15; 67(4):1166-76. PubMed ID: 15625278
    [Abstract] [Full Text] [Related]

  • 10. FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70.
    Wang Y, Wang SY, Zhang XH, Zhao M, Hou CM, Xu YJ, Du ZY, Yu XD.
    Biochem Biophys Res Commun; 2007 May 18; 356(4):998-1003. PubMed ID: 17397803
    [Abstract] [Full Text] [Related]

  • 11. Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.
    Fiskus W, Ren Y, Mohapatra A, Bali P, Mandawat A, Rao R, Herger B, Yang Y, Atadja P, Wu J, Bhalla K.
    Clin Cancer Res; 2007 Aug 15; 13(16):4882-90. PubMed ID: 17699868
    [Abstract] [Full Text] [Related]

  • 12. ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells.
    Cervantes-Gomez F, Nimmanapalli R, Gandhi V.
    J Pharmacol Exp Ther; 2011 Nov 15; 339(2):545-54. PubMed ID: 21821695
    [Abstract] [Full Text] [Related]

  • 13. Acetylation of Hsp90 reverses dexamethasone-mediated inhibition of insulin secretion.
    Zhu K, Zhang Y, Zhang J, Zhou F, Zhang L, Wang S, Zhu Q, Liu Q, Wang X, Zhou L.
    Toxicol Lett; 2020 Mar 01; 320():19-27. PubMed ID: 31778773
    [Abstract] [Full Text] [Related]

  • 14. HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling.
    Kekatpure VD, Dannenberg AJ, Subbaramaiah K.
    J Biol Chem; 2009 Mar 20; 284(12):7436-45. PubMed ID: 19158084
    [Abstract] [Full Text] [Related]

  • 15. Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
    Holmes JL, Sharp SY, Hobbs S, Workman P.
    Cancer Res; 2008 Feb 15; 68(4):1188-97. PubMed ID: 18281495
    [Abstract] [Full Text] [Related]

  • 16. Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors.
    Chai RC, Vieusseux JL, Lang BJ, Nguyen CH, Kouspou MM, Britt KL, Price JT.
    Mol Oncol; 2017 May 15; 11(5):567-583. PubMed ID: 28306192
    [Abstract] [Full Text] [Related]

  • 17. The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome.
    An WG, Schulte TW, Neckers LM.
    Cell Growth Differ; 2000 Jul 15; 11(7):355-60. PubMed ID: 10939589
    [Abstract] [Full Text] [Related]

  • 18. Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities.
    Newbold A, Matthews GM, Bots M, Cluse LA, Clarke CJ, Banks KM, Cullinane C, Bolden JE, Christiansen AJ, Dickins RA, Miccolo C, Chiocca S, Kral AM, Ozerova ND, Miller TA, Methot JL, Richon VM, Secrist JP, Minucci S, Johnstone RW.
    Mol Cancer Ther; 2013 Dec 15; 12(12):2709-21. PubMed ID: 24092806
    [Abstract] [Full Text] [Related]

  • 19. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.
    Krishnamoorthy GP, Guida T, Alfano L, Avilla E, Santoro M, Carlomagno F, Melillo RM.
    J Biol Chem; 2013 Jun 14; 288(24):17481-94. PubMed ID: 23629654
    [Abstract] [Full Text] [Related]

  • 20. Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C.
    Pelicano H, Carew JS, McQueen TJ, Andreeff M, Plunkett W, Keating MJ, Huang P.
    Leukemia; 2006 Apr 14; 20(4):610-9. PubMed ID: 16482209
    [Abstract] [Full Text] [Related]

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