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Journal Abstract Search

248 related items for PubMed ID: 18614364

  • 21. Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity.
    Liu KK, Lefker BA, Dombroski MA, Chiang P, Cornelius P, Patterson TA, Zeng Y, Santucci S, Tomlinson E, Gibbons CP, Marala R, Brown JA, Kong JX, Lee E, Werner W, Wenzel Z, Giragossian C, Chen H, Coffey SB.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2365-9. PubMed ID: 20202843
    [Abstract] [Full Text] [Related]

  • 22. Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists.
    Pettersson H, Bülow A, Ek F, Jensen J, Ottesen LK, Fejzic A, Ma JN, Del Tredici AL, Currier EA, Gardell LR, Tabatabaei A, Craig D, McFarland K, Ott TR, Piu F, Burstein ES, Olsson R.
    J Med Chem; 2009 Apr 09; 52(7):1975-82. PubMed ID: 19338356
    [Abstract] [Full Text] [Related]

  • 23. Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
    Mihalic JT, Chen X, Fan P, Chen X, Fu Y, Liang L, Reed M, Tang L, Chen JL, Jaen J, Li L, Dai K.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7001-5. PubMed ID: 22019296
    [Abstract] [Full Text] [Related]

  • 24. Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity.
    Elliott RL, Cameron KO, Chin JE, Bartlett JA, Beretta EE, Chen Y, Jardine Pda S, Dubins JS, Gillaspy ML, Hargrove DM, Kalgutkar AS, LaFlamme JA, Lame ME, Martin KA, Maurer TS, Nardone NA, Oliver RM, Scott DO, Sun D, Swick AG, Trebino CE, Zhang Y.
    Bioorg Med Chem Lett; 2010 Nov 15; 20(22):6797-801. PubMed ID: 20851601
    [Abstract] [Full Text] [Related]

  • 25. Discovery of a beta-MSH-derived MC-4R selective agonist.
    Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ.
    J Med Chem; 2005 May 05; 48(9):3095-8. PubMed ID: 15857110
    [Abstract] [Full Text] [Related]

  • 26. Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
    Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Dosa PI, Covel JA, Ren A, Webb RR, Beeley NR, Martin M, Morgan M, Espitia S, Saldana HR, Bjenning C, Whelan KT, Grottick AJ, Menzaghi F, Thomsen WJ.
    J Med Chem; 2008 Jan 24; 51(2):305-13. PubMed ID: 18095642
    [Abstract] [Full Text] [Related]

  • 27. Design, synthesis, and biological evaluation of substituted 2-cyclohexyl-4-phenyl-1H-imidazoles: potent and selective neuropeptide Y Y5-receptor antagonists.
    Blum CA, Zheng X, De Lombaert S.
    J Med Chem; 2004 Apr 22; 47(9):2318-25. PubMed ID: 15084130
    [Abstract] [Full Text] [Related]

  • 28. Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents.
    Li J, Bertinato P, Cheng H, Cole BM, Bronk BS, Jaynes BH, Hickman A, Haven ML, Kolosko NL, Barry CJ, Manion TB.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):3039-42. PubMed ID: 16529928
    [Abstract] [Full Text] [Related]

  • 29. Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.
    Becker DP, Flynn DL, Moormann AE, Nosal R, Villamil CI, Loeffler R, Gullikson GW, Moummi C, Yang DC.
    J Med Chem; 2006 Feb 09; 49(3):1125-39. PubMed ID: 16451077
    [Abstract] [Full Text] [Related]

  • 30. Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
    Liu J, He S, Jian T, Dobbelaar PH, Sebhat IK, Lin LS, Goodman A, Guo C, Guzzo PR, Hadden M, Henderson AJ, Pattamana K, Ruenz M, Sargent BJ, Swenson B, Yet L, Tamvakopoulos C, Peng Q, Pan J, Kan Y, Palyha O, Kelly TM, Guan XM, Howard AD, Marsh DJ, Metzger JM, Reitman ML, Wyvratt MJ, Nargund RP.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2074-7. PubMed ID: 20219372
    [Abstract] [Full Text] [Related]

  • 31. Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.
    Plummer CW, Finke PE, Mills SG, Wang J, Tong X, Doss GA, Fong TM, Lao JZ, Schaeffer MT, Chen J, Shen CP, Stribling DS, Shearman LP, Strack AM, Van der Ploeg LH.
    Bioorg Med Chem Lett; 2005 Mar 01; 15(5):1441-6. PubMed ID: 15713403
    [Abstract] [Full Text] [Related]

  • 32. Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.
    Terasaka T, Kinoshita T, Kuno M, Seki N, Tanaka K, Nakanishi I.
    J Med Chem; 2004 Jul 15; 47(15):3730-43. PubMed ID: 15239652
    [Abstract] [Full Text] [Related]

  • 33. Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity.
    Liu KK, Cornelius P, Patterson TA, Zeng Y, Santucci S, Tomlinson E, Gibbons C, Maurer TS, Marala R, Brown J, Kong JX, Lee E, Werner W, Wenzel Z, Vage C.
    Bioorg Med Chem Lett; 2010 Jan 01; 20(1):266-71. PubMed ID: 19914063
    [Abstract] [Full Text] [Related]

  • 34. Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
    He S, Ye Z, Dobbelaar PH, Sebhat IK, Guo L, Liu J, Jian T, Lai Y, Franklin CL, Bakshi RK, Dellureficio JP, Hong Q, Weinberg DH, Macneil T, Tang R, Strack AM, Tamvakopoulos C, Peng Q, Miller RR, Stearns RA, Chen HY, Chen AS, Fong TM, Wyvratt MJ, Nargund RP.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4399-405. PubMed ID: 20598882
    [Abstract] [Full Text] [Related]

  • 35. The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones.
    Fletcher SR, McIver E, Lewis S, Burkamp F, Leech C, Mason G, Boyce S, Morrison D, Richards G, Sutton K, Jones AB.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):2872-6. PubMed ID: 16563760
    [Abstract] [Full Text] [Related]

  • 36. Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.
    Ando M, Sekino E, Haga Y, Moriya M, Ito M, Ito J, Iwaasa H, Ishihara A, Kanatani A, Ohtake N.
    Bioorg Med Chem Lett; 2009 Sep 01; 19(17):5186-90. PubMed ID: 19632840
    [Abstract] [Full Text] [Related]

  • 37. Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists.
    Cameron KO, Beretta EE, Chen Y, Chu-Moyer M, Fernando D, Gao H, Kohrt J, Lavergne S, Jardine Pda S, Guzman-Perez A, Hoth C, Perry DA, Hadcock JR, Gautreau D, Makowski M, Perez S, Polivkova J, Rogers L, Scott DO, Swick AG, Thiede L, Trebino CE, Trilles RV, Wilmowski J, Zhang Y.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2943-7. PubMed ID: 22424974
    [Abstract] [Full Text] [Related]

  • 38. Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
    He S, Dobbelaar PH, Liu J, Jian T, Sebhat IK, Lin LS, Goodman A, Guo C, Guzzo PR, Hadden M, Henderson AJ, Ruenz M, Sargent BJ, Yet L, Kelly TM, Palyha O, Kan Y, Pan J, Chen H, Marsh DJ, Shearman LP, Strack AM, Metzger JM, Feighner SD, Tan C, Howard AD, Tamvakopoulos C, Peng Q, Guan XM, Reitman ML, Patchett AA, Wyvratt MJ, Nargund RP.
    Bioorg Med Chem Lett; 2010 Mar 15; 20(6):1913-7. PubMed ID: 20167483
    [Abstract] [Full Text] [Related]

  • 39. Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.
    Kopka IE, Lin LS, Jewell JP, Lanza TJ, Fong TM, Shen CP, Lao ZJ, Ha S, Castonguay LG, Van der Ploeg L, Goulet MT, Hagmann WK.
    Bioorg Med Chem Lett; 2010 Aug 15; 20(16):4757-61. PubMed ID: 20643546
    [Abstract] [Full Text] [Related]

  • 40. Novel substituted aminoalkylguanidines as potential antihyperglycemic and food intake-reducing agents.
    Tassoni E, Giannessi F, Brunetti T, Pessotto P, Renzulli M, Travagli M, Rajamäki S, Prati S, Dottori S, Corelli F, Cabri W, Carminati P, Botta M.
    J Med Chem; 2008 Jun 12; 51(11):3073-6. PubMed ID: 18465847
    [Abstract] [Full Text] [Related]

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