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239 related items for PubMed ID: 18620056

  • 1. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17beta-hydroxysteroid dehydrogenase (17beta-HSD3).
    Lota RK, Olusanjo MS, Dhanani S, Owen CP, Ahmed S.
    J Steroid Biochem Mol Biol; 2008 Jul; 111(1-2):128-37. PubMed ID: 18620056
    [Abstract] [Full Text] [Related]

  • 2. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3).
    Lota RK, Dhanani S, Owen CP, Ahmed S.
    Bioorg Med Chem Lett; 2006 Sep 01; 16(17):4519-22. PubMed ID: 16797984
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP, Shahid I, Olusanjo MS, Patel CH, Dhanani S, Ahmed S.
    J Steroid Biochem Mol Biol; 2008 Jul 01; 111(1-2):117-27. PubMed ID: 18620055
    [Abstract] [Full Text] [Related]

  • 4. Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes.
    Hu GX, Zhao B, Chu Y, Li XH, Akingbemi BT, Zheng ZQ, Ge RS.
    Int J Androl; 2011 Apr 01; 34(2):138-44. PubMed ID: 20522127
    [Abstract] [Full Text] [Related]

  • 5. Identification of novel functional inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3).
    Spires TE, Fink BE, Kick EK, You D, Rizzo CA, Takenaka I, Lawrence RM, Ruan Z, Salvati ME, Vite GD, Weinmann R, Attar RM, Gottardis MM, Lorenzi MV.
    Prostate; 2005 Oct 01; 65(2):159-70. PubMed ID: 15924334
    [Abstract] [Full Text] [Related]

  • 6. Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
    Day JM, Tutill HJ, Foster PA, Bailey HV, Heaton WB, Sharland CM, Vicker N, Potter BV, Purohit A, Reed MJ.
    Mol Cell Endocrinol; 2009 Mar 25; 301(1-2):251-8. PubMed ID: 18786604
    [Abstract] [Full Text] [Related]

  • 7. Effects of phthalates on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase 3 activities in human and rat testes.
    Yuan K, Zhao B, Li XW, Hu GX, Su Y, Chu Y, Akingbemi BT, Lian QQ, Ge RS.
    Chem Biol Interact; 2012 Feb 05; 195(3):180-8. PubMed ID: 22214983
    [Abstract] [Full Text] [Related]

  • 8. Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities.
    Perspicace E, Cozzoli L, Gargano EM, Hanke N, Carotti A, Hartmann RW, Marchais-Oberwinkler S.
    Eur J Med Chem; 2014 Aug 18; 83():317-37. PubMed ID: 24974351
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of human and rat 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities by perfluoroalkylated substances.
    Zhao B, Hu GX, Chu Y, Jin X, Gong S, Akingbemi BT, Zhang Z, Zirkin BR, Ge RS.
    Chem Biol Interact; 2010 Oct 06; 188(1):38-43. PubMed ID: 20619251
    [Abstract] [Full Text] [Related]

  • 10. The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes.
    Hu GX, Zhou HY, Li XW, Chen BB, Xiao YC, Lian QQ, Liang G, Kim HH, Zheng ZQ, Hardy DO, Ge RS.
    J Steroid Biochem Mol Biol; 2009 May 06; 115(1-2):14-9. PubMed ID: 19429456
    [Abstract] [Full Text] [Related]

  • 11. 6-Hydroxybenzothiophene ketones: potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) owing to favorable molecule geometry and conformational preorganization.
    Miralinaghi P, Schmitt C, Hartmann RW, Frotscher M, Engel M.
    ChemMedChem; 2014 Oct 06; 9(10):2294-308. PubMed ID: 25044709
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
    Bey E, Marchais-Oberwinkler S, Kruchten P, Frotscher M, Werth R, Oster A, Algül O, Neugebauer A, Hartmann RW.
    Bioorg Med Chem; 2008 Jun 15; 16(12):6423-35. PubMed ID: 18514529
    [Abstract] [Full Text] [Related]

  • 13. Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.
    Luu-The V, Tremblay P, Labrie F.
    Mol Endocrinol; 2006 Feb 15; 20(2):437-43. PubMed ID: 16166196
    [Abstract] [Full Text] [Related]

  • 14. Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer.
    Le Lain R, Nicholls PJ, Smith HJ, Maharlouie FH.
    J Enzyme Inhib; 2001 Jan 15; 16(1):35-45. PubMed ID: 11496833
    [Abstract] [Full Text] [Related]

  • 15. Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone.
    Möller G, Deluca D, Gege C, Rosinus A, Kowalik D, Peters O, Droescher P, Elger W, Adamski J, Hillisch A.
    Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6740-4. PubMed ID: 19836949
    [Abstract] [Full Text] [Related]

  • 16. Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone.
    Laplante Y, Cadot C, Fournier MA, Poirier D.
    Bioorg Med Chem; 2008 Feb 15; 16(4):1849-60. PubMed ID: 18035543
    [Abstract] [Full Text] [Related]

  • 17. Specific estradiol biosynthetic pathway in choriocarcinoma (JEG-3) cell line.
    Samson M, Labrie F, Luu-The V.
    J Steroid Biochem Mol Biol; 2009 Sep 15; 116(3-5):154-9. PubMed ID: 19465125
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid.
    Zhao B, Chu Y, Hardy DO, Li XK, Ge RS.
    J Steroid Biochem Mol Biol; 2010 Jan 15; 118(1-2):13-7. PubMed ID: 19818404
    [Abstract] [Full Text] [Related]

  • 19. Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17beta-hydroxysteroid dehydrogenase type 1.
    Bérubé M, Poirier D.
    J Enzyme Inhib Med Chem; 2009 Jun 15; 24(3):832-43. PubMed ID: 19003559
    [Abstract] [Full Text] [Related]

  • 20. STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model.
    Day JM, Foster PA, Tutill HJ, Schmidlin F, Sharland CM, Hargrave JD, Vicker N, Potter BV, Reed MJ, Purohit A.
    Endocr Relat Cancer; 2013 Feb 15; 20(1):53-64. PubMed ID: 23132791
    [Abstract] [Full Text] [Related]

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