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304 related items for PubMed ID: 18621077
1. Preclinical Torsades-de-Pointes screens: advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk. Gintant GA. Pharmacol Ther; 2008 Aug; 119(2):199-209. PubMed ID: 18621077 [Abstract] [Full Text] [Related]
2. The continuing evolution of torsades de pointes liability testing methods: is there an end in sight? Lee N, Authier S, Pugsley MK, Curtis MJ. Toxicol Appl Pharmacol; 2010 Mar 01; 243(2):146-53. PubMed ID: 20005885 [Abstract] [Full Text] [Related]
3. Utility of hERG assays as surrogate markers of delayed cardiac repolarization and QT safety. Gintant GA, Su Z, Martin RL, Cox BF. Toxicol Pathol; 2006 Mar 01; 34(1):81-90. PubMed ID: 16507548 [Abstract] [Full Text] [Related]
5. The canine model with chronic, complete atrio-ventricular block. Oros A, Beekman JD, Vos MA. Pharmacol Ther; 2008 Aug 01; 119(2):168-78. PubMed ID: 18514320 [Abstract] [Full Text] [Related]
6. Early clinical development: evaluation of drug-induced torsades de pointes risk. Vik T, Pollard C, Sager P. Pharmacol Ther; 2008 Aug 01; 119(2):210-4. PubMed ID: 18601950 [Abstract] [Full Text] [Related]
7. Torsades de pointes liability inter-model comparisons: the experience of the QT PRODACT initiative. Hashimoto K. Pharmacol Ther; 2008 Aug 01; 119(2):195-8. PubMed ID: 18486227 [Abstract] [Full Text] [Related]
12. Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias. Thomsen MB, Matz J, Volders PG, Vos MA. Pharmacol Ther; 2006 Oct 01; 112(1):150-70. PubMed ID: 16714061 [Abstract] [Full Text] [Related]
13. Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia. Said TH, Wilson LD, Jeyaraj D, Fossa AA, Rosenbaum DS. J Cardiovasc Pharmacol; 2012 Aug 01; 60(2):165-71. PubMed ID: 22561361 [Abstract] [Full Text] [Related]
14. In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation. Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ. Eur J Pharmacol; 2006 Dec 28; 553(1-3):229-39. PubMed ID: 17054943 [Abstract] [Full Text] [Related]
15. Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends. Hoffmann P, Warner B. J Pharmacol Toxicol Methods; 2006 Dec 28; 53(2):87-105. PubMed ID: 16289936 [Abstract] [Full Text] [Related]
18. An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation. Gintant G. Pharmacol Ther; 2011 Feb 28; 129(2):109-19. PubMed ID: 20807552 [Abstract] [Full Text] [Related]
19. Ventricular rate adaptation: a novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds. Green JR, Diaz GJ, Limberis JT, Houseman KA, Su Z, Martin RL, Cox BF, Kantor S, Gintant GA. J Pharmacol Toxicol Methods; 2011 Feb 28; 64(1):68-73. PubMed ID: 21440075 [Abstract] [Full Text] [Related]
20. Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts. Sugiyama A. Br J Pharmacol; 2008 Aug 28; 154(7):1528-37. PubMed ID: 18552873 [Abstract] [Full Text] [Related] Page: [Next] [New Search]