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Journal Abstract Search


304 related items for PubMed ID: 18621077

  • 1. Preclinical Torsades-de-Pointes screens: advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk.
    Gintant GA.
    Pharmacol Ther; 2008 Aug; 119(2):199-209. PubMed ID: 18621077
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  • 2. The continuing evolution of torsades de pointes liability testing methods: is there an end in sight?
    Lee N, Authier S, Pugsley MK, Curtis MJ.
    Toxicol Appl Pharmacol; 2010 Mar 01; 243(2):146-53. PubMed ID: 20005885
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  • 3. Utility of hERG assays as surrogate markers of delayed cardiac repolarization and QT safety.
    Gintant GA, Su Z, Martin RL, Cox BF.
    Toxicol Pathol; 2006 Mar 01; 34(1):81-90. PubMed ID: 16507548
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  • 5. The canine model with chronic, complete atrio-ventricular block.
    Oros A, Beekman JD, Vos MA.
    Pharmacol Ther; 2008 Aug 01; 119(2):168-78. PubMed ID: 18514320
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  • 6. Early clinical development: evaluation of drug-induced torsades de pointes risk.
    Vik T, Pollard C, Sager P.
    Pharmacol Ther; 2008 Aug 01; 119(2):210-4. PubMed ID: 18601950
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  • 7. Torsades de pointes liability inter-model comparisons: the experience of the QT PRODACT initiative.
    Hashimoto K.
    Pharmacol Ther; 2008 Aug 01; 119(2):195-8. PubMed ID: 18486227
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  • 9. Nonclinical proarrhythmia models: predicting Torsades de Pointes.
    Lawrence CL, Pollard CE, Hammond TG, Valentin JP.
    J Pharmacol Toxicol Methods; 2005 Aug 01; 52(1):46-59. PubMed ID: 15975832
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  • 12. Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.
    Thomsen MB, Matz J, Volders PG, Vos MA.
    Pharmacol Ther; 2006 Oct 01; 112(1):150-70. PubMed ID: 16714061
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  • 13. Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
    Said TH, Wilson LD, Jeyaraj D, Fossa AA, Rosenbaum DS.
    J Cardiovasc Pharmacol; 2012 Aug 01; 60(2):165-71. PubMed ID: 22561361
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  • 14. In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.
    Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ.
    Eur J Pharmacol; 2006 Dec 28; 553(1-3):229-39. PubMed ID: 17054943
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  • 15. Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends.
    Hoffmann P, Warner B.
    J Pharmacol Toxicol Methods; 2006 Dec 28; 53(2):87-105. PubMed ID: 16289936
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  • 18. An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation.
    Gintant G.
    Pharmacol Ther; 2011 Feb 28; 129(2):109-19. PubMed ID: 20807552
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  • 19. Ventricular rate adaptation: a novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds.
    Green JR, Diaz GJ, Limberis JT, Houseman KA, Su Z, Martin RL, Cox BF, Kantor S, Gintant GA.
    J Pharmacol Toxicol Methods; 2011 Feb 28; 64(1):68-73. PubMed ID: 21440075
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  • 20. Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts.
    Sugiyama A.
    Br J Pharmacol; 2008 Aug 28; 154(7):1528-37. PubMed ID: 18552873
    [Abstract] [Full Text] [Related]


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