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388 related items for PubMed ID: 18625202

  • 1. HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway.
    Fuchs D, Berges C, Opelz G, Daniel V, Naujokat C.
    Biochem Biophys Res Commun; 2008 Sep 19; 374(2):309-14. PubMed ID: 18625202
    [Abstract] [Full Text] [Related]

  • 2. Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells.
    Saito A, Saito N, Mol W, Furukawa H, Tsutsumida A, Oyama A, Sekido M, Sasaki S, Yamamoto Y.
    Melanoma Res; 2008 Apr 19; 18(2):85-94. PubMed ID: 18337644
    [Abstract] [Full Text] [Related]

  • 3. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.
    Lee MH, Cho YS, Han YM.
    Stem Cells; 2007 Jul 19; 25(7):1654-63. PubMed ID: 17464088
    [Abstract] [Full Text] [Related]

  • 4. RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation.
    Fromigué O, Haÿ E, Modrowski D, Bouvet S, Jacquel A, Auberger P, Marie PJ.
    Cell Death Differ; 2006 Nov 19; 13(11):1845-56. PubMed ID: 16470222
    [Abstract] [Full Text] [Related]

  • 5. Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.
    Tang D, Park HJ, Georgescu SP, Sebti SM, Hamilton AD, Galper JB.
    Life Sci; 2006 Sep 05; 79(15):1484-92. PubMed ID: 16740276
    [Abstract] [Full Text] [Related]

  • 6. Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cells.
    Fuchs D, Berges C, Opelz G, Daniel V, Naujokat C.
    J Cell Biochem; 2008 Jan 01; 103(1):270-83. PubMed ID: 17516511
    [Abstract] [Full Text] [Related]

  • 7. Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products.
    Liang YJ, Shyu KG, Wang BW, Lai LP.
    Cardiology; 2008 Jan 01; 110(3):182-90. PubMed ID: 18057884
    [Abstract] [Full Text] [Related]

  • 8. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation.
    Al-Haidari AA, Syk I, Thorlacius H.
    Biochem Biophys Res Commun; 2014 Mar 28; 446(1):68-72. PubMed ID: 24582560
    [Abstract] [Full Text] [Related]

  • 9. Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels.
    Baiz D, Pozzato G, Dapas B, Farra R, Scaggiante B, Grassi M, Uxa L, Giansante C, Zennaro C, Guarnieri G, Grassi G.
    Biochimie; 2009 Mar 28; 91(3):373-82. PubMed ID: 19041685
    [Abstract] [Full Text] [Related]

  • 10. Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA.
    Porter KE, Turner NA, O'Regan DJ, Balmforth AJ, Ball SG.
    Cardiovasc Res; 2004 Mar 01; 61(4):745-55. PubMed ID: 14985071
    [Abstract] [Full Text] [Related]

  • 11. Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin.
    Hu WL, Qiao SB, Li JJ.
    Cytokine; 2007 Dec 01; 40(3):201-6. PubMed ID: 18023360
    [Abstract] [Full Text] [Related]

  • 12. [Inhibition of proliferation and induction of apoptosis by simvastatin in K562 leukemic cell line].
    Ren H, Zhang N, Xu H, Lu D.
    Zhonghua Xue Ye Xue Za Zhi; 2001 Feb 01; 22(2):72-5. PubMed ID: 11877052
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of Barret's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins.
    Konturek PC, Burnat G, Hahn EG.
    J Physiol Pharmacol; 2007 Aug 01; 58 Suppl 3():141-8. PubMed ID: 17901590
    [Abstract] [Full Text] [Related]

  • 14. Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line.
    Ghosh PM, Ghosh-Choudhury N, Moyer ML, Mott GE, Thomas CA, Foster BA, Greenberg NM, Kreisberg JI.
    Oncogene; 1999 Jul 15; 18(28):4120-30. PubMed ID: 10435593
    [Abstract] [Full Text] [Related]

  • 15. Statins induce differentiation and cell death in neurons and astroglia.
    März P, Otten U, Miserez AR.
    Glia; 2007 Jan 01; 55(1):1-12. PubMed ID: 16998865
    [Abstract] [Full Text] [Related]

  • 16. Differential sensitivity of breast cancer and melanoma cells to proteasome inhibitor Velcade.
    Yerlikaya A, Erin N.
    Int J Mol Med; 2008 Dec 01; 22(6):817-23. PubMed ID: 19020781
    [Abstract] [Full Text] [Related]

  • 17. Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro.
    Demyanets S, Kaun C, Pfaffenberger S, Hohensinner PJ, Rega G, Pammer J, Maurer G, Huber K, Wojta J.
    Biochem Pharmacol; 2006 Apr 28; 71(9):1324-30. PubMed ID: 16540096
    [Abstract] [Full Text] [Related]

  • 18. A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.
    Podar K, Gouill SL, Zhang J, Opferman JT, Zorn E, Tai YT, Hideshima T, Amiot M, Chauhan D, Harousseau JL, Anderson KC.
    Oncogene; 2008 Jan 31; 27(6):721-31. PubMed ID: 17653083
    [Abstract] [Full Text] [Related]

  • 19. Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway.
    Song JX, Ren JY, Chen H.
    J Cardiovasc Pharmacol; 2011 Feb 31; 57(2):213-22. PubMed ID: 21052011
    [Abstract] [Full Text] [Related]

  • 20. The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines.
    Strauss SJ, Higginbottom K, Jüliger S, Maharaj L, Allen P, Schenkein D, Lister TA, Joel SP.
    Cancer Res; 2007 Mar 15; 67(6):2783-90. PubMed ID: 17363600
    [Abstract] [Full Text] [Related]

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