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Journal Abstract Search

606 related items for PubMed ID: 18632688

  • 1.
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  • 2. In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.
    Thomas EA, Coppola G, Tang B, Kuhn A, Kim S, Geschwind DH, Brown TB, Luthi-Carter R, Ehrlich ME.
    Hum Mol Genet; 2011 Mar 15; 20(6):1049-60. PubMed ID: 21177255
    [Abstract] [Full Text] [Related]

  • 3. Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
    Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.
    Neurobiol Dis; 2008 Jul 15; 31(1):80-8. PubMed ID: 18502655
    [Abstract] [Full Text] [Related]

  • 4. Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.
    Gharami K, Xie Y, An JJ, Tonegawa S, Xu B.
    J Neurochem; 2008 Apr 15; 105(2):369-79. PubMed ID: 18086127
    [Abstract] [Full Text] [Related]

  • 5. Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.
    Wang N, Gray M, Lu XH, Cantle JP, Holley SM, Greiner E, Gu X, Shirasaki D, Cepeda C, Li Y, Dong H, Levine MS, Yang XW.
    Nat Med; 2014 May 15; 20(5):536-41. PubMed ID: 24784230
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  • 6. Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo Models.
    Creus-Muncunill J, Ehrlich ME.
    Neurotherapeutics; 2019 Oct 15; 16(4):957-978. PubMed ID: 31529216
    [Abstract] [Full Text] [Related]

  • 7. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.
    Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S.
    Proc Natl Acad Sci U S A; 2009 Dec 29; 106(52):22480-5. PubMed ID: 20018729
    [Abstract] [Full Text] [Related]

  • 8. Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.
    Menalled LB, Sison JD, Wu Y, Olivieri M, Li XJ, Li H, Zeitlin S, Chesselet MF.
    J Neurosci; 2002 Sep 15; 22(18):8266-76. PubMed ID: 12223581
    [Abstract] [Full Text] [Related]

  • 9. Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice.
    Naydenov AV, Sepers MD, Swinney K, Raymond LA, Palmiter RD, Stella N.
    Neurobiol Dis; 2014 Nov 15; 71():140-50. PubMed ID: 25134728
    [Abstract] [Full Text] [Related]

  • 10. Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.
    Cowan CM, Fan MM, Fan J, Shehadeh J, Zhang LY, Graham RK, Hayden MR, Raymond LA.
    J Neurosci; 2008 Nov 26; 28(48):12725-35. PubMed ID: 19036965
    [Abstract] [Full Text] [Related]

  • 11. Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.
    Reddy PH, Charles V, Williams M, Miller G, Whetsell WO, Tagle DA.
    Philos Trans R Soc Lond B Biol Sci; 1999 Jun 29; 354(1386):1035-45. PubMed ID: 10434303
    [Abstract] [Full Text] [Related]

  • 12. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
    Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.
    Cell Death Differ; 2004 Apr 29; 11(4):424-38. PubMed ID: 14713958
    [Abstract] [Full Text] [Related]

  • 13. Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
    Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R.
    Hum Mol Genet; 2007 Aug 01; 16(15):1845-61. PubMed ID: 17519223
    [Abstract] [Full Text] [Related]

  • 14. Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.
    Jin J, Peng Q, Hou Z, Jiang M, Wang X, Langseth AJ, Tao M, Barker PB, Mori S, Bergles DE, Ross CA, Detloff PJ, Zhang J, Duan W.
    Hum Mol Genet; 2015 May 01; 24(9):2508-27. PubMed ID: 25609071
    [Abstract] [Full Text] [Related]

  • 15. Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load.
    Milnerwood AJ, Raymond LA.
    J Physiol; 2007 Dec 15; 585(Pt 3):817-31. PubMed ID: 17947312
    [Abstract] [Full Text] [Related]

  • 16. BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice.
    Xie Y, Hayden MR, Xu B.
    J Neurosci; 2010 Nov 03; 30(44):14708-18. PubMed ID: 21048129
    [Abstract] [Full Text] [Related]

  • 17.
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  • 18. Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.
    Kim SH, Thomas CA, André VM, Cummings DM, Cepeda C, Levine MS, Ehrlich ME.
    ASN Neuro; 2011 Jun 07; 3(3):e00060. PubMed ID: 21542802
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  • 19.
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  • 20. Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.
    Menalled LB, Sison JD, Dragatsis I, Zeitlin S, Chesselet MF.
    J Comp Neurol; 2003 Oct 06; 465(1):11-26. PubMed ID: 12926013
    [Abstract] [Full Text] [Related]

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