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312 related items for PubMed ID: 18657969

  • 1. Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site.
    Torbeev VY, Mandal K, Terechko VA, Kent SB.
    Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4554-7. PubMed ID: 18657969
    [Abstract] [Full Text] [Related]

  • 2. Reprint of "Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site" [Bioorg. Med. Chem. Lett. 18 (2008) 4554-4557].
    Torbeev VY, Mandal K, Terechko VA, Kent SB.
    Bioorg Med Chem Lett; 2008 Nov 15; 18(22):6012-5. PubMed ID: 18995173
    [Abstract] [Full Text] [Related]

  • 3. An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study.
    Skálová T, Hasek J, Dohnálek J, Petroková H, Buchtelová E, Dusková J, Soucek M, Majer P, Uhlíková T, Konvalinka J.
    J Med Chem; 2003 Apr 24; 46(9):1636-44. PubMed ID: 12699382
    [Abstract] [Full Text] [Related]

  • 4. On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 A resolution.
    Dusková J, Dohnálek J, Skálová T, Petroková H, Vondrácková E, Hradílek M, Konvalinka J, Soucek M, Brynda J, Fábry M, Sedlácek J, Hasek J.
    Acta Crystallogr D Biol Crystallogr; 2006 May 24; 62(Pt 5):489-97. PubMed ID: 16627941
    [Abstract] [Full Text] [Related]

  • 5. Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
    Bäckbro K, Löwgren S, Osterlund K, Atepo J, Unge T, Hultén J, Bonham NM, Schaal W, Karlén A, Hallberg A.
    J Med Chem; 1997 Mar 14; 40(6):898-902. PubMed ID: 9083478
    [Abstract] [Full Text] [Related]

  • 6. Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex.
    Brynda J, Rezácová P, Fábry M, Horejsí M, Stouracová R, Soucek M, Hradílek M, Konvalinka J, Sedlácek J.
    Acta Crystallogr D Biol Crystallogr; 2004 Nov 14; 60(Pt 11):1943-8. PubMed ID: 15502300
    [Abstract] [Full Text] [Related]

  • 7. Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease.
    Louis JM, Dyda F, Nashed NT, Kimmel AR, Davies DR.
    Biochemistry; 1998 Feb 24; 37(8):2105-10. PubMed ID: 9485357
    [Abstract] [Full Text] [Related]

  • 8. Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.
    Beaulieu PL, Wernic D, Abraham A, Anderson PC, Bogri T, Bousquet Y, Croteau G, Guse I, Lamarre D, Liard F, Paris W, Thibeault D, Pav S, Tong L.
    J Med Chem; 1997 Jul 04; 40(14):2164-76. PubMed ID: 9216835
    [Abstract] [Full Text] [Related]

  • 9. Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation.
    Ghosh AK, Kincaid JF, Walters DE, Chen Y, Chaudhuri NC, Thompson WJ, Culberson C, Fitzgerald PM, Lee HY, McKee SP, Munson PM, Duong TT, Darke PL, Zugay JA, Schleif WA, Axel MG, Lin J, Huff JR.
    J Med Chem; 1996 Aug 16; 39(17):3278-90. PubMed ID: 8765511
    [Abstract] [Full Text] [Related]

  • 10. Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.
    Ghosh AK, Swanson LM, Cho H, Leshchenko S, Hussain KA, Kay S, Walters DE, Koh Y, Mitsuya H.
    J Med Chem; 2005 May 19; 48(10):3576-85. PubMed ID: 15887965
    [Abstract] [Full Text] [Related]

  • 11. Targeting the open-flap conformation of HIV-1 protease with pyrrolidine-based inhibitors.
    Böttcher J, Blum A, Dörr S, Heine A, Diederich WE, Klebe G.
    ChemMedChem; 2008 Sep 19; 3(9):1337-44. PubMed ID: 18720485
    [Abstract] [Full Text] [Related]

  • 12. Rapid screening for HIV-1 protease inhibitor leads through X-ray diffraction.
    Pillai B, Kannan KK, Bhat SV, Hosur MV.
    Acta Crystallogr D Biol Crystallogr; 2004 Mar 19; 60(Pt 3):594-6. PubMed ID: 14993705
    [Abstract] [Full Text] [Related]

  • 13. Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.
    Bihani SC, Das A, Prashar V, Ferrer JL, Hosur MV.
    Biochem Biophys Res Commun; 2009 Nov 13; 389(2):295-300. PubMed ID: 19720046
    [Abstract] [Full Text] [Related]

  • 14. Comparative studies on inhibitors of HIV protease: a target for drug design.
    Jayaraman S, Shah K.
    In Silico Biol; 2008 Nov 13; 8(5-6):427-47. PubMed ID: 19374129
    [Abstract] [Full Text] [Related]

  • 15. Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3.
    Heaslet H, Kutilek V, Morris GM, Lin YC, Elder JH, Torbett BE, Stout CD.
    J Mol Biol; 2006 Mar 03; 356(4):967-81. PubMed ID: 16403521
    [Abstract] [Full Text] [Related]

  • 16. X-ray structure of HIV-1 protease in situ product complex.
    Bihani S, Das A, Prashar V, Ferrer JL, Hosur MV.
    Proteins; 2009 Feb 15; 74(3):594-602. PubMed ID: 18704947
    [Abstract] [Full Text] [Related]

  • 17. Active site binding modes of curcumin in HIV-1 protease and integrase.
    Vajragupta O, Boonchoong P, Morris GM, Olson AJ.
    Bioorg Med Chem Lett; 2005 Jul 15; 15(14):3364-8. PubMed ID: 15950462
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.
    Smith AB, Charnley AK, Harada H, Beiger JJ, Cantin LD, Kenesky CS, Hirschmann R, Munshi S, Olsen DB, Stahlhut MW, Schleif WA, Kuo LC.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(4):859-63. PubMed ID: 16298527
    [Abstract] [Full Text] [Related]

  • 19. Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic.
    Kiso Y, Matsumoto H, Mizumoto S, Kimura T, Fujiwara Y, Akaji K.
    Biopolymers; 1999 Feb 15; 51(1):59-68. PubMed ID: 10380353
    [Abstract] [Full Text] [Related]

  • 20. Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes.
    Rezácová P, Pokorná J, Brynda J, Kozísek M, Cígler P, Lepsík M, Fanfrlík J, Rezác J, Grantz Sasková K, Sieglová I, Plesek J, Sícha V, Grüner B, Oberwinkler H, Sedlácek' J, Kräusslich HG, Hobza P, Král V, Konvalinka J.
    J Med Chem; 2009 Nov 26; 52(22):7132-41. PubMed ID: 19874035
    [Abstract] [Full Text] [Related]

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