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Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

343 related items for PubMed ID: 18662879

  • 1. Discovery of piperidine carboxamide TRPV1 antagonists.
    Cheung WS, Calvo RR, Tounge BA, Zhang SP, Stone DR, Brandt MR, Hutchinson T, Flores CM, Player MR.
    Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4569-72. PubMed ID: 18662879
    [Abstract] [Full Text] [Related]

  • 2. Spiro-piperidine azetidinones as potent TRPV1 antagonists.
    Xiao D, Palani A, Aslanian R, McKittrick BA, McPhail AT, Correll CC, Phelps PT, Anthes JC, Rindgen D.
    Bioorg Med Chem Lett; 2009 Feb 01; 19(3):783-7. PubMed ID: 19114307
    [Abstract] [Full Text] [Related]

  • 3. Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.
    Westaway SM, Thompson M, Rami HK, Stemp G, Trouw LS, Mitchell DJ, Seal JT, Medhurst SJ, Lappin SC, Biggs J, Wright J, Arpino S, Jerman JC, Cryan JE, Holland V, Winborn KY, Coleman T, Stevens AJ, Davis JB, Gunthorpe MJ.
    Bioorg Med Chem Lett; 2008 Oct 15; 18(20):5609-13. PubMed ID: 18809327
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists.
    Xi N, Bo Y, Doherty EM, Fotsch C, Gavva NR, Han N, Hungate RW, Klionsky L, Liu Q, Tamir R, Xu S, Treanor JJ, Norman MH.
    Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5211-7. PubMed ID: 16203144
    [Abstract] [Full Text] [Related]

  • 5. CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives.
    Lu SF, Chen B, Davey D, Dunning L, Jaroch S, May K, Onuffer J, Phillips G, Subramanyam B, Tseng JL, Wei RG, Wei M, Ye B.
    Bioorg Med Chem Lett; 2007 Apr 01; 17(7):1883-7. PubMed ID: 17314043
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists.
    Li FN, Kim NJ, Paek SM, Kwon DY, Min KH, Jeong YS, Kim SY, Park YH, Kim HD, Park HG, Suh YG.
    Bioorg Med Chem; 2009 May 15; 17(10):3557-67. PubMed ID: 19398205
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists.
    Xia M, Hou C, DeMong D, Pollack S, Pan M, Singer M, Matheis M, Murray W, Cavender D, Wachter M.
    Bioorg Med Chem Lett; 2008 Dec 15; 18(24):6468-70. PubMed ID: 18990568
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of indole-based peptoids as potent noncompetitive antagonists of transient receptor potential vanilloid 1.
    Quintanar-Audelo M, Fernández-Carvajal A, Van Den Nest W, Carreño C, Ferrer-Montiel A, Albericio F.
    J Med Chem; 2007 Nov 29; 50(24):6133-43. PubMed ID: 17985859
    [Abstract] [Full Text] [Related]

  • 9. Small, non-peptide C5a receptor antagonists: part 2.
    Blagg J, Mowbray C, Pryde D, Salmon G, Fairman D, Schmid E, Beaumont K.
    Bioorg Med Chem Lett; 2008 Oct 15; 18(20):5605-8. PubMed ID: 18804369
    [Abstract] [Full Text] [Related]

  • 10. The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones.
    Fletcher SR, McIver E, Lewis S, Burkamp F, Leech C, Mason G, Boyce S, Morrison D, Richards G, Sutton K, Jones AB.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):2872-6. PubMed ID: 16563760
    [Abstract] [Full Text] [Related]

  • 11. Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.
    Ratcliffe P, Abernethy L, Ansari N, Cameron K, Clarkson T, Dempster M, Dunn D, Easson AM, Edwards D, Everett K, Feilden H, Ho KK, Kultgen S, Littlewood P, Maclean J, McArthur D, McGregor D, McLuskey H, Neagu I, Nimz O, Nisbet LA, Ohlmeyer M, Palin R, Pham Q, Rong Y, Roughton A, Sammons M, Swanson R, Tracey H, Walker G.
    Bioorg Med Chem Lett; 2011 Aug 01; 21(15):4652-7. PubMed ID: 21723725
    [Abstract] [Full Text] [Related]

  • 12. Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats.
    Lehto SG, Tamir R, Deng H, Klionsky L, Kuang R, Le A, Lee D, Louis JC, Magal E, Manning BH, Rubino J, Surapaneni S, Tamayo N, Wang T, Wang J, Wang J, Wang W, Youngblood B, Zhang M, Zhu D, Norman MH, Gavva NR.
    J Pharmacol Exp Ther; 2008 Jul 01; 326(1):218-29. PubMed ID: 18420600
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis, and biological evaluation of phenylpropanamides as novel transient receptor potential vanilloid 1 antagonists.
    Li FN, Kim NJ, Nam YH, Kim SH, Seo SY, Jeong YS, Kim SY, Park YH, Suh YG.
    Arch Pharm Res; 2009 Sep 01; 32(9):1201-10. PubMed ID: 19784574
    [Abstract] [Full Text] [Related]

  • 14. Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists.
    Chen JJ, Qian W, Biswas K, Viswanadhan VN, Askew BC, Hitchcock S, Hungate RW, Arik L, Johnson E.
    Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4477-81. PubMed ID: 18674903
    [Abstract] [Full Text] [Related]

  • 15. Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility.
    Wang X, Chakrabarti PP, Ognyanov VI, Pettus LH, Tamir R, Tan H, Tang P, Treanor JJ, Gavva NR, Norman MH.
    Bioorg Med Chem Lett; 2007 Dec 01; 17(23):6539-45. PubMed ID: 17937985
    [Abstract] [Full Text] [Related]

  • 16. Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists.
    Tamayo N, Liao H, Stec MM, Wang X, Chakrabarti P, Retz D, Doherty EM, Surapaneni S, Tamir R, Bannon AW, Gavva NR, Norman MH.
    J Med Chem; 2008 May 08; 51(9):2744-57. PubMed ID: 18386885
    [Abstract] [Full Text] [Related]

  • 17. TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives.
    Congiu C, Onnis V, Balboni G, Schiano-Moriello A, Di Marzo V, De Petrocellis L.
    Eur J Med Chem; 2015 Jul 15; 100():129-38. PubMed ID: 26079089
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists.
    Perner RJ, Koenig JR, Didomenico S, Gomtsyan A, Schmidt RG, Lee CH, Hsu MC, McDonald HA, Gauvin DM, Joshi S, Turner TM, Reilly RM, Kym PR, Kort ME.
    Bioorg Med Chem; 2010 Jul 01; 18(13):4821-9. PubMed ID: 20570528
    [Abstract] [Full Text] [Related]

  • 19. Discovery of novel aminothiadiazole amides as selective EP(3) receptor antagonists.
    Hilfiker MA, Wang N, Hou X, Du Z, Pullen MA, Nord M, Nagilla R, Fries HE, Wu CW, Sulpizio AC, Jaworski JP, Morrow D, Edwards RM, Jin J.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4292-5. PubMed ID: 19487124
    [Abstract] [Full Text] [Related]

  • 20. Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists.
    Hall A, Billinton A, Bristow AK, Brown SH, Chowdhury A, Cutler L, Giblin GM, Goldsmith P, Hayhow TG, Kilford IR, Naylor A, Passingham B, Rawlings DA.
    Bioorg Med Chem Lett; 2008 Jul 15; 18(14):4027-32. PubMed ID: 18571922
    [Abstract] [Full Text] [Related]

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