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Journal Abstract Search

191 related items for PubMed ID: 18684621

  • 1. 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.
    Berger R, Zhu C, Hansen AR, Harper B, Chen Z, Holt TG, Hubert J, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, Wolff M, Macneil DJ, Weber AE, Edmondson SD.
    Bioorg Med Chem Lett; 2008 Sep 01; 18(17):4833-7. PubMed ID: 18684621
    [Abstract] [Full Text] [Related]

  • 2. Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
    Zhu C, Hansen AR, Bateman T, Chen Z, Holt TG, Hubert JA, Karanam BV, Lee SJ, Pan J, Qian S, Reddy VB, Reitman ML, Strack AM, Tong V, Weingarth DT, Wolff MS, MacNeil DJ, Weber AE, Duffy JL, Edmondson SD.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4393-6. PubMed ID: 18614364
    [Abstract] [Full Text] [Related]

  • 3. Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.
    Yu M, Lizarzaburu M, Beckmann H, Connors R, Dai K, Haller K, Li C, Liang L, Lindstrom M, Ma J, Motani A, Wanska M, Zhang A, Li L, Medina JC.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1758-62. PubMed ID: 20137933
    [Abstract] [Full Text] [Related]

  • 4. Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity.
    Elliott RL, Cameron KO, Chin JE, Bartlett JA, Beretta EE, Chen Y, Jardine Pda S, Dubins JS, Gillaspy ML, Hargrove DM, Kalgutkar AS, LaFlamme JA, Lame ME, Martin KA, Maurer TS, Nardone NA, Oliver RM, Scott DO, Sun D, Swick AG, Trebino CE, Zhang Y.
    Bioorg Med Chem Lett; 2010 Nov 15; 20(22):6797-801. PubMed ID: 20851601
    [Abstract] [Full Text] [Related]

  • 5. Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
    Wang L, Hubert JA, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, MacNeil DJ, Weber AE, Edmondson SD.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):2911-5. PubMed ID: 21493064
    [Abstract] [Full Text] [Related]

  • 6. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.
    Vachal P, Fletcher JM, Fong TM, Huang CC, Lao J, Xiao JC, Shen CP, Strack AM, Shearman L, Stribling S, Chen RZ, Frassetto A, Tong X, Wang J, Ball RG, Tsou NN, Hickey GJ, Thompson DF, Faidley TD, Nicolich S, Achanfuo-Yeboah J, Hora DF, Hale JJ, Hagmann WK.
    J Med Chem; 2009 Apr 23; 52(8):2550-8. PubMed ID: 19320488
    [Abstract] [Full Text] [Related]

  • 7. Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
    Wacker DA, Varnes JG, Malmstrom SE, Cao X, Hung CP, Ung T, Wu G, Zhang G, Zuvich E, Thomas MA, Keim WJ, Cullen MJ, Rohrbach KW, Qu Q, Narayanan R, Rossi K, Janovitz E, Lehman-McKeeman L, Malley MF, Devenny J, Pelleymounter MA, Miller KJ, Robl JA.
    J Med Chem; 2007 Mar 22; 50(6):1365-79. PubMed ID: 17315987
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity.
    Liu KK, Cornelius P, Patterson TA, Zeng Y, Santucci S, Tomlinson E, Gibbons C, Maurer TS, Marala R, Brown J, Kong JX, Lee E, Werner W, Wenzel Z, Vage C.
    Bioorg Med Chem Lett; 2010 Jan 01; 20(1):266-71. PubMed ID: 19914063
    [Abstract] [Full Text] [Related]

  • 9. Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.
    Henke BR, Aquino CJ, Birkemo LS, Croom DK, Dougherty RW, Ervin GN, Grizzle MK, Hirst GC, James MK, Johnson MF, Queen KL, Sherrill RG, Sugg EE, Suh EM, Szewczyk JW, Unwalla RJ, Yingling J, Willson TM.
    J Med Chem; 1997 Aug 15; 40(17):2706-25. PubMed ID: 9276016
    [Abstract] [Full Text] [Related]

  • 10. Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
    Mihalic JT, Chen X, Fan P, Chen X, Fu Y, Liang L, Reed M, Tang L, Chen JL, Jaen J, Li L, Dai K.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7001-5. PubMed ID: 22019296
    [Abstract] [Full Text] [Related]

  • 11. Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.
    Hirst GC, Aquino C, Birkemo L, Croom DK, Dezube M, Dougherty RW, Ervin GN, Grizzle MK, Henke B, James MK, Johnson MF, Momtahen T, Queen KL, Sherrill RG, Szewczyk J, Willson TM, Sugg EE.
    J Med Chem; 1996 Dec 20; 39(26):5236-45. PubMed ID: 8978852
    [Abstract] [Full Text] [Related]

  • 12. Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
    Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Dosa PI, Covel JA, Ren A, Webb RR, Beeley NR, Martin M, Morgan M, Espitia S, Saldana HR, Bjenning C, Whelan KT, Grottick AJ, Menzaghi F, Thomsen WJ.
    J Med Chem; 2008 Jan 24; 51(2):305-13. PubMed ID: 18095642
    [Abstract] [Full Text] [Related]

  • 13. The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process.
    Escrieut C, Gigoux V, Archer E, Verrier S, Maigret B, Behrendt R, Moroder L, Bignon E, Silvente-Poirot S, Pradayrol L, Fourmy D.
    J Biol Chem; 2002 Mar 01; 277(9):7546-55. PubMed ID: 11724786
    [Abstract] [Full Text] [Related]

  • 14. Discovery of novel orally active ureido NPY Y5 receptor antagonists.
    Li G, Stamford AW, Huang Y, Cheng KC, Cook J, Farley C, Gao J, Ghibaudi L, Greenlee WJ, Guzzi M, van Heek M, Hwa JJ, Kelly J, Mullins D, Parker EM, Wainhaus S, Zhang X.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):1146-50. PubMed ID: 18160282
    [Abstract] [Full Text] [Related]

  • 15. Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist "trigger".
    Aquino CJ, Armour DR, Berman JM, Birkemo LS, Carr RA, Croom DK, Dezube M, Dougherty RW, Ervin GN, Grizzle MK, Head JE, Hirst GC, James MK, Johnson MF, Miller LJ, Queen KL, Rimele TJ, Smith DN, Sugg EE.
    J Med Chem; 1996 Jan 19; 39(2):562-9. PubMed ID: 8558528
    [Abstract] [Full Text] [Related]

  • 16. Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents.
    Li J, Bertinato P, Cheng H, Cole BM, Bronk BS, Jaynes BH, Hickman A, Haven ML, Kolosko NL, Barry CJ, Manion TB.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):3039-42. PubMed ID: 16529928
    [Abstract] [Full Text] [Related]

  • 17. Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.
    Borza I, Bozó E, Barta-Szalai G, Kiss C, Tárkányi G, Demeter A, Gáti T, Háda V, Kolok S, Gere A, Fodor L, Nagy J, Galgóczy K, Magdó I, Agai B, Fetter J, Bertha F, Keserü GM, Horváth C, Farkas S, Greiner I, Domány G.
    J Med Chem; 2007 Mar 08; 50(5):901-14. PubMed ID: 17290978
    [Abstract] [Full Text] [Related]

  • 18. Novel selective neuropeptide Y2 receptor PEGylated peptide agonists reduce food intake and body weight in mice.
    Lumb KJ, DeCarr LB, Milardo LF, Mays MR, Buckholz TM, Fisk SE, Pellegrino CM, Ortiz AA, Mahle CD.
    J Med Chem; 2007 May 03; 50(9):2264-8. PubMed ID: 17425299
    [Abstract] [Full Text] [Related]

  • 19. Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.
    Tian X, Switzer AG, Derose SA, Mishra RK, Solinsky MG, Mumin RN, Ebetino FH, Jayasinghe LR, Webster ME, Colson AO, Crossdoersen D, Pinney BB, Farmer JA, Dowty ME, Obringer CM, Cruze CA, Burklow ML, Suchanek PM, Dong L, Dirr MK, Sheldon RJ, Wos JA.
    J Med Chem; 2008 Oct 09; 51(19):6055-66. PubMed ID: 18771254
    [Abstract] [Full Text] [Related]

  • 20. Discovery of a beta-MSH-derived MC-4R selective agonist.
    Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ.
    J Med Chem; 2005 May 05; 48(9):3095-8. PubMed ID: 15857110
    [Abstract] [Full Text] [Related]

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