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Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

154 related items for PubMed ID: 18690722

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  • 6. Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.
    Lecoeur S, Bonierbale E, Challine D, Gautier JC, Valadon P, Dansette PM, Catinot R, Ballet F, Mansuy D, Beaune PH.
    Chem Res Toxicol; 1994; 7(3):434-42. PubMed ID: 8075377
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  • 8. Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam.
    Barnette DA, Schleiff MA, Osborn LR, Flynn N, Matlock M, Swamidass SJ, Miller GP.
    Toxicology; 2020 Jul; 440():152478. PubMed ID: 32437779
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  • 9. Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds.
    Bonierbale E, Valadon P, Pons C, Desfosses B, Dansette PM, Mansuy D.
    Chem Res Toxicol; 1999 Mar; 12(3):286-96. PubMed ID: 10077492
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  • 10. Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression.
    Leone AM, Kao LM, McMillian MK, Nie AY, Parker JB, Kelley MF, Usuki E, Parkinson A, Lord PG, Johnson MD.
    Chem Res Toxicol; 2007 Apr; 20(4):600-8. PubMed ID: 17381134
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  • 11. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N, Makino C, Murayama N.
    Chem Res Toxicol; 2007 Mar; 20(3):455-64. PubMed ID: 17309281
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  • 13. The role of P-glycoprotein in the bioactivation of raloxifene.
    Chang JH, Kochansky CJ, Shou M.
    Drug Metab Dispos; 2006 Dec; 34(12):2073-8. PubMed ID: 16959878
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  • 14. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
    Teffera Y, Choquette D, Liu J, Colletti AE, Hollis LS, Lin MH, Zhao Z.
    Chem Res Toxicol; 2010 Nov 15; 23(11):1743-52. PubMed ID: 20825217
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  • 15. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.
    Obach RS.
    Drug Metab Dispos; 1997 Dec 15; 25(12):1359-69. PubMed ID: 9394025
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  • 17. The use of cultured hepatocytes to investigate the metabolism of drugs and mechanisms of drug hepatotoxicity.
    Gómez-Lechón MJ, Ponsoda X, Bort R, Castell JV.
    Altern Lab Anim; 2001 Dec 15; 29(3):225-31. PubMed ID: 11387019
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  • 19. Comparison of inhibition potentials of drugs against zidovudine glucuronidation in rat hepatocytes and liver microsomes.
    Mano Y, Usui T, Kamimura H.
    Drug Metab Dispos; 2007 Apr 15; 35(4):602-6. PubMed ID: 17267620
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