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361 related items for PubMed ID: 18708578

  • 1. Tumorigenic activity and therapeutic inhibition of Rheb GTPase.
    Mavrakis KJ, Zhu H, Silva RL, Mills JR, Teruya-Feldstein J, Lowe SW, Tam W, Pelletier J, Wendel HG.
    Genes Dev; 2008 Aug 15; 22(16):2178-88. PubMed ID: 18708578
    [Abstract] [Full Text] [Related]

  • 2. Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
    Nardella C, Chen Z, Salmena L, Carracedo A, Alimonti A, Egia A, Carver B, Gerald W, Cordon-Cardo C, Pandolfi PP.
    Genes Dev; 2008 Aug 15; 22(16):2172-7. PubMed ID: 18708577
    [Abstract] [Full Text] [Related]

  • 3. The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.
    Basso AD, Mirza A, Liu G, Long BJ, Bishop WR, Kirschmeier P.
    J Biol Chem; 2005 Sep 02; 280(35):31101-8. PubMed ID: 16006564
    [Abstract] [Full Text] [Related]

  • 4. Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.
    Wagner RJ, Martin KA, Powell RJ, Rzucidlo EM.
    Am J Physiol Cell Physiol; 2010 Jul 02; 299(1):C119-27. PubMed ID: 20375271
    [Abstract] [Full Text] [Related]

  • 5. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.
    Cell Signal; 2014 Mar 02; 26(3):461-7. PubMed ID: 24316235
    [Abstract] [Full Text] [Related]

  • 6. PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
    Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H.
    J Biol Chem; 2014 Oct 24; 289(43):29739-49. PubMed ID: 25164809
    [Abstract] [Full Text] [Related]

  • 7. Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells.
    Zheng H, Liu A, Liu B, Li M, Yu H, Luo X.
    Cancer Lett; 2010 Nov 01; 297(1):117-25. PubMed ID: 20554106
    [Abstract] [Full Text] [Related]

  • 8. MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.
    Fawal MA, Brandt M, Djouder N.
    Dev Cell; 2015 Apr 06; 33(1):67-81. PubMed ID: 25816988
    [Abstract] [Full Text] [Related]

  • 9. Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.
    Gau CL, Kato-Stankiewicz J, Jiang C, Miyamoto S, Guo L, Tamanoi F.
    Mol Cancer Ther; 2005 Jun 06; 4(6):918-26. PubMed ID: 15956249
    [Abstract] [Full Text] [Related]

  • 10. Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.
    Groenewoud MJ, Goorden SM, Kassies J, Pellis-van Berkel W, Lamb RF, Elgersma Y, Zwartkruis FJ.
    PLoS One; 2013 Jun 06; 8(11):e81649. PubMed ID: 24303063
    [Abstract] [Full Text] [Related]

  • 11. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
    Sato T, Nakashima A, Guo L, Tamanoi F.
    J Biol Chem; 2009 May 08; 284(19):12783-91. PubMed ID: 19299511
    [Abstract] [Full Text] [Related]

  • 12. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.
    Jiang L, Xu L, Mao J, Li J, Fang L, Zhou Y, Liu W, He W, Zhao AZ, Yang J, Dai C.
    J Am Soc Nephrol; 2013 Jun 08; 24(7):1114-26. PubMed ID: 23661807
    [Abstract] [Full Text] [Related]

  • 13. Alkaline intracellular pH (pHi) increases PI3K activity to promote mTORC1 and mTORC2 signaling and function during growth factor limitation.
    Kazyken D, Lentz SI, Wadley M, Fingar DC.
    J Biol Chem; 2023 Sep 08; 299(9):105097. PubMed ID: 37507012
    [Abstract] [Full Text] [Related]

  • 14. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation.
    Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS, Hunzicker-Dunn M.
    J Biol Chem; 2004 May 07; 279(19):19431-40. PubMed ID: 14982927
    [Abstract] [Full Text] [Related]

  • 15. Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
    Karassek S, Berghaus C, Schwarten M, Goemans CG, Ohse N, Kock G, Jockers K, Neumann S, Gottfried S, Herrmann C, Heumann R, Stoll R.
    J Biol Chem; 2010 Oct 29; 285(44):33979-91. PubMed ID: 20685651
    [Abstract] [Full Text] [Related]

  • 16. Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.
    Sato T, Umetsu A, Tamanoi F.
    Methods Enzymol; 2008 Oct 29; 438():307-20. PubMed ID: 18413257
    [Abstract] [Full Text] [Related]

  • 17. Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells.
    Ding H, McDonald JS, Yun S, Schneider PA, Peterson KL, Flatten KS, Loegering DA, Oberg AL, Riska SM, Huang S, Sinicrope FA, Adjei AA, Karp JE, Meng XW, Kaufmann SH.
    Haematologica; 2014 Jan 29; 99(1):60-9. PubMed ID: 23996484
    [Abstract] [Full Text] [Related]

  • 18. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.
    Carroll B, Maetzel D, Maddocks OD, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI.
    Elife; 2016 Jan 07; 5():. PubMed ID: 26742086
    [Abstract] [Full Text] [Related]

  • 19. Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.
    Lee MN, Ha SH, Kim J, Koh A, Lee CS, Kim JH, Jeon H, Kim DH, Suh PG, Ryu SH.
    Mol Cell Biol; 2009 Jul 07; 29(14):3991-4001. PubMed ID: 19451232
    [Abstract] [Full Text] [Related]

  • 20. Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.
    Wang X, Fonseca BD, Tang H, Liu R, Elia A, Clemens MJ, Bommer UA, Proud CG.
    J Biol Chem; 2008 Nov 07; 283(45):30482-92. PubMed ID: 18676370
    [Abstract] [Full Text] [Related]

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