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Journal Abstract Search

180 related items for PubMed ID: 18717481

  • 1. Novel oxazole containing phenylpropane derivatives as peroxisome proliferator activated receptor agonists with hypolipidemic activity.
    Pingali H, Raval S, Raval P, Makadia P, Zaware P, Goel A, Suthar D, Jain M, Patel P.
    Pharmazie; 2008 Jul; 63(7):497-502. PubMed ID: 18717481
    [Abstract] [Full Text] [Related]

  • 2. Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
    Aoki T, Asaki T, Hamamoto T, Sugiyama Y, Ohmachi S, Kuwabara K, Murakami K, Todo M.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):2128-32. PubMed ID: 18280733
    [Abstract] [Full Text] [Related]

  • 3. Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.
    Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R, Cheng L, Sleph P, Sun W, Tieman A, Wetterau JR, Doweyko A, Chandrasena G, Chang SY, Humphreys WG, Sasseville VG, Biller SA, Ryono DE, Selan F, Hariharan N, Cheng PT.
    J Med Chem; 2005 Mar 24; 48(6):2248-50. PubMed ID: 15771468
    [Abstract] [Full Text] [Related]

  • 4. Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
    Asaki T, Aoki T, Hamamoto T, Sugiyama Y, Ohmachi S, Kuwabara K, Murakami K, Todo M.
    Bioorg Med Chem; 2008 Jan 15; 16(2):981-94. PubMed ID: 17964792
    [Abstract] [Full Text] [Related]

  • 5. PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.
    Kim MK, Chae YN, Son MH, Kim SH, Kim JK, Moon HS, Park CS, Bae MH, Kim E, Han T, Choi HH, Shin YA, Ahn BN, Lee CH, Lim JI, Shin CY.
    Eur J Pharmacol; 2008 Oct 24; 595(1-3):119-25. PubMed ID: 18727927
    [Abstract] [Full Text] [Related]

  • 6. Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
    Pingali H, Jain M, Shah S, Basu S, Makadia P, Goswami A, Zaware P, Patil P, Godha A, Giri S, Goel A, Patel M, Patel H, Patel P.
    Bioorg Med Chem Lett; 2008 Oct 15; 18(20):5586-90. PubMed ID: 18805005
    [Abstract] [Full Text] [Related]

  • 7. Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
    Pingali H, Jain M, Shah S, Makadia P, Zaware P, Goel A, Patel M, Giri S, Patel H, Patel P.
    Bioorg Med Chem; 2008 Aug 01; 16(15):7117-27. PubMed ID: 18625559
    [Abstract] [Full Text] [Related]

  • 8. Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.
    Liu K, Xu L, Berger JP, Macnaul KL, Zhou G, Doebber TW, Forrest MJ, Moller DE, Jones AB.
    J Med Chem; 2005 Apr 07; 48(7):2262-5. PubMed ID: 15801817
    [Abstract] [Full Text] [Related]

  • 9. Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
    Shi GQ, Dropinski JF, McKeever BM, Xu S, Becker JW, Berger JP, MacNaul KL, Elbrecht A, Zhou G, Doebber TW, Wang P, Chao YS, Forrest M, Heck JV, Moller DE, Jones AB.
    J Med Chem; 2005 Jun 30; 48(13):4457-68. PubMed ID: 15974597
    [Abstract] [Full Text] [Related]

  • 10. Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy.
    Rudolph J, Chen L, Majumdar D, Bullock WH, Burns M, Claus T, Dela Cruz FE, Daly M, Ehrgott FJ, Johnson JS, Livingston JN, Schoenleber RW, Shapiro J, Yang L, Tsutsumi M, Ma X.
    J Med Chem; 2007 Mar 08; 50(5):984-1000. PubMed ID: 17274610
    [Abstract] [Full Text] [Related]

  • 11. N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.
    Cobb JE, Blanchard SG, Boswell EG, Brown KK, Charifson PS, Cooper JP, Collins JL, Dezube M, Henke BR, Hull-Ryde EA, Lake DH, Lenhard JM, Oliver W, Oplinger J, Pentti M, Parks DJ, Plunket KD, Tong WQ.
    J Med Chem; 1998 Dec 03; 41(25):5055-69. PubMed ID: 9836622
    [Abstract] [Full Text] [Related]

  • 12. Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists.
    Pingali H, Jain M, Shah S, Zaware P, Makadia P, Pola S, Thube B, Patel D, Patil P, Priyadarshini P, Suthar D, Shah M, Giri S, Patel P.
    Bioorg Med Chem Lett; 2010 Feb 01; 20(3):1156-61. PubMed ID: 20022492
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
    Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ.
    J Med Chem; 2008 Oct 23; 51(20):6318-33. PubMed ID: 18826205
    [Abstract] [Full Text] [Related]

  • 14. Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo.
    Kane CD, Stevens KA, Fischer JE, Haghpassand M, Royer LJ, Aldinger C, Landschulz KT, Zagouras P, Bagley SW, Hada W, Dullea R, Hayward CM, Francone OL.
    Mol Pharmacol; 2009 Feb 23; 75(2):296-306. PubMed ID: 18971326
    [Abstract] [Full Text] [Related]

  • 15. In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway.
    Takeuchi S, Matsuda T, Kobayashi S, Takahashi T, Kojima H.
    Toxicol Appl Pharmacol; 2006 Dec 15; 217(3):235-44. PubMed ID: 17084873
    [Abstract] [Full Text] [Related]

  • 16. Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.
    Rau O, Syha Y, Zettl H, Kock M, Bock A, Schubert-Zsilavecz M.
    Arch Pharm (Weinheim); 2008 Mar 15; 341(3):191-5. PubMed ID: 18275039
    [Abstract] [Full Text] [Related]

  • 17. Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.
    Shi GQ, Dropinski JF, Zhang Y, Santini C, Sahoo SP, Berger JP, Macnaul KL, Zhou G, Agrawal A, Alvaro R, Cai TQ, Hernandez M, Wright SD, Moller DE, Heck JV, Meinke PT.
    J Med Chem; 2005 Aug 25; 48(17):5589-99. PubMed ID: 16107159
    [Abstract] [Full Text] [Related]

  • 18. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice.
    Kuwabara K, Murakami K, Todo M, Aoki T, Asaki T, Murai M, Yano J.
    J Pharmacol Exp Ther; 2004 Jun 25; 309(3):970-7. PubMed ID: 14982965
    [Abstract] [Full Text] [Related]

  • 19. [4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs).
    Sparatore A, Godio C, Perrino E, Romeo S, Staels B, Fruchart JC, Crestani M.
    Chem Biodivers; 2006 Apr 25; 3(4):385-95. PubMed ID: 17193275
    [Abstract] [Full Text] [Related]

  • 20. N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
    Collins JL, Blanchard SG, Boswell GE, Charifson PS, Cobb JE, Henke BR, Hull-Ryde EA, Kazmierski WM, Lake DH, Leesnitzer LM, Lehmann J, Lenhard JM, Orband-Miller LA, Gray-Nunez Y, Parks DJ, Plunkett KD, Tong WQ.
    J Med Chem; 1998 Dec 03; 41(25):5037-54. PubMed ID: 9836621
    [Abstract] [Full Text] [Related]

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