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Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

152 related items for PubMed ID: 18729327

  • 1. Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6.
    Kent UM, Sridar C, Spahlinger G, Hollenberg PF.
    Chem Res Toxicol; 2008 Oct; 21(10):1956-63. PubMed ID: 18729327
    [Abstract] [Full Text] [Related]

  • 2. Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites.
    Kent UM, Mills DE, Rajnarayanan RV, Alworth WL, Hollenberg PF.
    J Pharmacol Exp Ther; 2002 Feb; 300(2):549-58. PubMed ID: 11805216
    [Abstract] [Full Text] [Related]

  • 3. Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
    Kent UM, Lin HL, Mills DE, Regal KA, Hollenberg PF.
    Chem Res Toxicol; 2006 Feb; 19(2):279-87. PubMed ID: 16485904
    [Abstract] [Full Text] [Related]

  • 4. Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity.
    Bumpus NN, Hollenberg PF.
    Mol Pharmacol; 2008 Oct; 74(4):990-9. PubMed ID: 18621926
    [Abstract] [Full Text] [Related]

  • 5. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.
    Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF.
    Drug Metab Dispos; 2000 Aug; 28(8):905-11. PubMed ID: 10901699
    [Abstract] [Full Text] [Related]

  • 6. The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis.
    Lin HL, Kent UM, Zhang H, Waskell L, Hollenberg PF.
    J Pharmacol Exp Ther; 2004 Dec; 311(3):855-63. PubMed ID: 15302894
    [Abstract] [Full Text] [Related]

  • 7. Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites.
    Von Weymarn LB, Sridar C, Hollenberg PF.
    J Pharmacol Exp Ther; 2004 Oct; 311(1):71-9. PubMed ID: 15178696
    [Abstract] [Full Text] [Related]

  • 8. Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.
    Harleton E, Webster M, Bumpus NN, Kent UM, Rae JM, Hollenberg PF.
    J Pharmacol Exp Ther; 2004 Sep; 310(3):1011-9. PubMed ID: 15121764
    [Abstract] [Full Text] [Related]

  • 9. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by n-propylxanthate.
    Kent UM, Yanev S, Hollenberg PF.
    Chem Res Toxicol; 1999 Apr; 12(4):317-22. PubMed ID: 10207119
    [Abstract] [Full Text] [Related]

  • 10. Selective pathways for the metabolism of phencyclidine by cytochrome p450 2b enzymes: identification of electrophilic metabolites, glutathione, and N-acetyl cysteine adducts.
    Shebley M, Jushchyshyn MI, Hollenberg PF.
    Drug Metab Dispos; 2006 Mar; 34(3):375-83. PubMed ID: 16326815
    [Abstract] [Full Text] [Related]

  • 11. Roles of the threonine 407, aspartic acid 417, and threonine 419 residues in P450 2B1 in metabolism.
    Sridar C, Harleton E, Hollenberg PF.
    Biochem Biophys Res Commun; 2005 Dec 09; 338(1):386-93. PubMed ID: 16157292
    [Abstract] [Full Text] [Related]

  • 12. The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI, Kent UM, Hollenberg PF.
    Drug Metab Dispos; 2003 Jan 09; 31(1):46-52. PubMed ID: 12485952
    [Abstract] [Full Text] [Related]

  • 13. Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI, Wahlstrom JL, Hollenberg PF, Wienkers LC.
    Drug Metab Dispos; 2006 Sep 09; 34(9):1523-9. PubMed ID: 16782764
    [Abstract] [Full Text] [Related]

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  • 16. Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling.
    Shebley M, Kent UM, Ballou DP, Hollenberg PF.
    Drug Metab Dispos; 2009 Apr 09; 37(4):745-52. PubMed ID: 19144770
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  • 18. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
    Lin HL, Kent UM, Hollenberg PF.
    J Pharmacol Exp Ther; 2005 Apr 09; 313(1):154-64. PubMed ID: 15608076
    [Abstract] [Full Text] [Related]

  • 19. Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite.
    Lin HL, Kent UM, Zhang H, Waskell L, Hollenberg PF.
    Chem Res Toxicol; 2003 Feb 09; 16(2):129-36. PubMed ID: 12588183
    [Abstract] [Full Text] [Related]

  • 20. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.
    Chem Res Toxicol; 2007 Oct 09; 20(10):1488-97. PubMed ID: 17892269
    [Abstract] [Full Text] [Related]

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