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Journal Abstract Search

895 related items for PubMed ID: 18757741

  • 1. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
    Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.
    Proc Natl Acad Sci U S A; 2008 Sep 09; 105(36):13568-73. PubMed ID: 18757741
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  • 2. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
    Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.
    Mol Cell Biol; 2004 Aug 09; 24(16):7130-9. PubMed ID: 15282312
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  • 10. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A, Motohashi H.
    Nitric Oxide; 2011 Aug 01; 25(2):153-60. PubMed ID: 21385624
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  • 11. Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.
    Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB.
    Cancer Res; 2014 Feb 01; 74(3):808-17. PubMed ID: 24322982
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  • 12. Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.
    Fukutomi T, Takagi K, Mizushima T, Ohuchi N, Yamamoto M.
    Mol Cell Biol; 2014 Mar 01; 34(5):832-46. PubMed ID: 24366543
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  • 13. Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.
    Iso T, Suzuki T, Baird L, Yamamoto M.
    Mol Cell Biol; 2016 Dec 15; 36(24):3100-3112. PubMed ID: 27697860
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  • 14. Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer.
    Martinez VD, Vucic EA, Pikor LA, Thu KL, Hubaux R, Lam WL.
    Mol Cancer; 2013 Oct 20; 12(1):124. PubMed ID: 24138990
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  • 15. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
    Sun Z, Zhang S, Chan JY, Zhang DD.
    Mol Cell Biol; 2007 Sep 20; 27(18):6334-49. PubMed ID: 17636022
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  • 16. Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer.
    Namani A, Matiur Rahaman M, Chen M, Tang X.
    BMC Cancer; 2018 Jan 06; 18(1):46. PubMed ID: 29306329
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  • 17. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
    Villeneuve NF, Lau A, Zhang DD.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1699-712. PubMed ID: 20486766
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  • 18. Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
    Baird L, Dinkova-Kostova AT.
    Biochem Biophys Res Commun; 2013 Mar 29; 433(1):58-65. PubMed ID: 23454126
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  • 19. Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer.
    Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL.
    Biomed Res Int; 2014 Mar 29; 2014():159459. PubMed ID: 25114896
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  • 20. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
    Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD.
    Mol Cell Biol; 2010 Jul 29; 30(13):3275-85. PubMed ID: 20421418
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